PMID- 34805417
OWN - NLM
STAT- MEDLINE
DCOM- 20220310
LR  - 20240229
IS  - 2314-7156 (Electronic)
IS  - 2314-8861 (Print)
IS  - 2314-7156 (Linking)
VI  - 2021
DP  - 2021
TI  - NFIB-Mediated lncRNA PVT1 Aggravates Laryngeal Squamous Cell Carcinoma 
      Progression via the miR-1301-3p/MBNL1 Axis.
PG  - 8675123
LID - 10.1155/2021/8675123 [doi]
LID - 8675123
AB  - Laryngeal squamous cell carcinoma (LSCC) is one of the most common malignant 
      tumors of head and neck cancers. In the past decades, although the therapy 
      strategies of LSCC have made considerable improvement, the terrible outcomes of 
      LSCC still bring an enormous burden to the world health care system. Novel 
      therapeutic targets for LSCC are urgently needed. lncRNAs exert important roles 
      in various biological progressions, including LSCC. Here, we aimed to investigate 
      the function of lncRNA PVT1 in LSCC progression and its underlying molecular 
      mechanisms. By conducting multiple experiments, our results showed that lncRNA 
      PVT1 was upregulated in LSCC cell lines and regulated LSCC cell proliferation, 
      apoptosis, and its cell susceptibility to natural killer (NK) cells. Moreover, it 
      was found that lncRNA PVT1 promotes MBNL1 expression to regulate LSCC cellular 
      progression through sponging miR-1301-3p. Our study might provide novel targets 
      for LSCC basic research or clinical management.
CI  - Copyright (c) 2021 Tian Tang and Feng Zeng.
FAU - Tang, Tian
AU  - Tang T
AUID- ORCID: 0000-0002-4438-4902
AD  - Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
FAU - Zeng, Feng
AU  - Zeng F
AD  - Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan 
      University, Wuhan, Hubei, China.
LA  - eng
PT  - Journal Article
DEP - 20211112
PL  - Egypt
TA  - J Immunol Res
JT  - Journal of immunology research
JID - 101627166
RN  - 0 (MBNL1 protein, human)
RN  - 0 (MIRN1301 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (NFI Transcription Factors)
RN  - 0 (NFIB protein, human)
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (RNA-Binding Proteins)
SB  - IM
MH  - Apoptosis
MH  - Carcinogenesis
MH  - Carcinoma, Squamous Cell/*genetics
MH  - Disease Progression
MH  - Gene Expression Regulation, Neoplastic
MH  - HEK293 Cells
MH  - Humans
MH  - Killer Cells, Natural/*immunology
MH  - Laryngeal Neoplasms/*genetics
MH  - MicroRNAs/*genetics/metabolism
MH  - NFI Transcription Factors/*metabolism
MH  - RNA, Long Noncoding/*genetics
MH  - RNA-Binding Proteins/*metabolism
MH  - Signal Transduction
PMC - PMC8604577
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2021/11/23 06:00
MHDA- 2022/03/11 06:00
PMCR- 2021/11/12
CRDT- 2021/11/22 06:55
PHST- 2021/05/14 00:00 [received]
PHST- 2021/09/07 00:00 [revised]
PHST- 2021/10/20 00:00 [accepted]
PHST- 2021/11/22 06:55 [entrez]
PHST- 2021/11/23 06:00 [pubmed]
PHST- 2022/03/11 06:00 [medline]
PHST- 2021/11/12 00:00 [pmc-release]
AID - 10.1155/2021/8675123 [doi]
PST - epublish
SO  - J Immunol Res. 2021 Nov 12;2021:8675123. doi: 10.1155/2021/8675123. eCollection 
      2021.