PMID- 34807997
OWN - NLM
STAT- MEDLINE
DCOM- 20220415
LR  - 20220415
IS  - 1552-8618 (Electronic)
IS  - 0730-7268 (Linking)
VI  - 41
IP  - 1
DP  - 2022 Jan
TI  - Species- and Tissue-Specific Chronic Toxicity Values for Northern Bobwhite Quail 
      (Colinus virginianus) Exposed to Perfluorohexane Sulfonic Acid and a Binary 
      Mixture of Perfluorooctane Sulfonic Acid and Perfluorohexane Sulfonic Acid.
PG  - 219-229
LID - 10.1002/etc.5238 [doi]
AB  - Per- and polyfluoroalkyl substances (PFAS) are globally distributed and present 
      in nearly every environmental compartment. Characterizing the chronic toxicity of 
      individual PFAS compounds and mixtures is necessary because many have been 
      reported to cause adverse health effects. To derive toxicity reference values 
      (TRVs) and conduct ecotoxicological risk assessments (ERAs) of PFAS-contaminated 
      ecosystems for wildlife, species-specific PFAS chronic toxicity values (CTVs) are 
      needed. The present study quantified PFAS residues from liver and eggs of birds 
      chronically exposed to perfluorohexanoic acid (PFHxA) or a mixture of 
      perfluorooctane sulfonate (PFOS) and PFHxA that produced a 
      no-observable-adverse-effect level (NOAEL) and/or a 
      lowest-observable-adverse-effectlevel (LOAEL). The CTVs we present are lower than 
      those previously reported for birds and should be considered in future regulatory 
      evaluations. From the estimated species- and tissue-specific PFAS CTVs, we found 
      that PFOS and perfluorohexane sulfonate (PFHxS) were more bioaccumulative than 
      PFHxA in avian tissues, but PFHxA was more toxic to reproducing birds than either 
      PFOS or a PFOS:PFHxS mixture. We further determined that avian toxicity was not 
      necessarily additive with respect to PFAS mixtures, which could have implications 
      for PFAS ERAs. The PFAS LOAEL CTVs can be used to predict reproductive and 
      possible population-level adverse health effects in wild avian receptors. Environ 
      Toxicol Chem 2022;41:219-229. (c) 2021 SETAC.
CI  - (c) 2021 SETAC.
FAU - Dennis, Nicole M
AU  - Dennis NM
AUID- ORCID: 0000-0002-1551-6267
AD  - Department of Environmental Toxicology, Texas Tech University, Lubbock, Texas, 
      USA.
FAU - Hossain, Farzana
AU  - Hossain F
AD  - Department of Environmental Toxicology, Texas Tech University, Lubbock, Texas, 
      USA.
FAU - Subbiah, Seenivasan
AU  - Subbiah S
AD  - Department of Environmental Toxicology, Texas Tech University, Lubbock, Texas, 
      USA.
FAU - Karnjanapiboonwong, Adcharee
AU  - Karnjanapiboonwong A
AD  - Department of Environmental Toxicology, Texas Tech University, Lubbock, Texas, 
      USA.
FAU - Dennis, Michael L
AU  - Dennis ML
AD  - Department of Environmental Toxicology, Texas Tech University, Lubbock, Texas, 
      USA.
FAU - McCarthy, Christopher
AU  - McCarthy C
AUID- ORCID: 0000-0002-5587-8203
AD  - Jacobs, Boston, Massachusetts, USA.
FAU - Jackson, W Andrew
AU  - Jackson WA
AD  - Department of Civil, Environmental, & Construction Engineering, Texas Tech 
      University, Lubbock, Texas, USA.
FAU - Crago, Jordan P
AU  - Crago JP
AD  - Department of Environmental Toxicology, Texas Tech University, Lubbock, Texas, 
      USA.
FAU - Salice, Christopher J
AU  - Salice CJ
AUID- ORCID: 0000-0002-3510-2918
AD  - Department of Biological Sciences, Towson University, Towson, Maryland, USA.
FAU - Anderson, Todd A
AU  - Anderson TA
AD  - Department of Environmental Toxicology, Texas Tech University, Lubbock, Texas, 
      USA.
LA  - eng
SI  - figshare/10.6084/m9.figshare.14442728
GR  - ER-2627/Strategic Environmental Research and Development Program/
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20211216
PL  - United States
TA  - Environ Toxicol Chem
JT  - Environmental toxicology and chemistry
JID - 8308958
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Fluorocarbons)
RN  - 0 (Sulfonic Acids)
RN  - 9H2MAI21CL (perfluorooctane sulfonic acid)
RN  - FX3WJ41CMX (perflexane)
SB  - IM
MH  - *Alkanesulfonic Acids/toxicity
MH  - Animals
MH  - Birds
MH  - *Colinus
MH  - Ecosystem
MH  - *Fluorocarbons/analysis/toxicity
MH  - Sulfonic Acids
OTO - NOTNLM
OT  - Analytical chemistry
OT  - Avian toxicity
OT  - Bioaccumulative compounds
OT  - Mixture toxicology
OT  - Per- and polyfluoroalkyl substances
OT  - Risk assessment
EDAT- 2021/11/23 06:00
MHDA- 2022/04/16 06:00
CRDT- 2021/11/22 17:26
PHST- 2021/10/23 00:00 [revised]
PHST- 2021/08/07 00:00 [received]
PHST- 2021/10/25 00:00 [accepted]
PHST- 2021/11/23 06:00 [pubmed]
PHST- 2022/04/16 06:00 [medline]
PHST- 2021/11/22 17:26 [entrez]
AID - 10.1002/etc.5238 [doi]
PST - ppublish
SO  - Environ Toxicol Chem. 2022 Jan;41(1):219-229. doi: 10.1002/etc.5238. Epub 2021 
      Dec 16.