PMID- 34808290
OWN - NLM
STAT- MEDLINE
DCOM- 20220314
LR  - 20220314
IS  - 1090-2139 (Electronic)
IS  - 0889-1591 (Linking)
VI  - 100
DP  - 2022 Feb
TI  - Inflammatory markers in type 2 diabetes with vs. without cognitive impairment; a 
      systematic review and meta-analysis.
PG  - 55-69
LID - S0889-1591(21)00601-2 [pii]
LID - 10.1016/j.bbi.2021.11.005 [doi]
AB  - People with type 2 diabetes mellitus (T2DM) are at increased risk of mild 
      cognitive impairment and dementia. Systemic inflammation has been proposed as a 
      common risk factor. This study aimed to summarize the clinical data pertaining to 
      peripheral blood inflammatory markers. We identified original peer-reviewed 
      articles reporting blood inflammatory marker concentrations in groups of people 
      with a T2DM diagnosis who have cognitive impairment (CI; including mild cognitive 
      impairment, Alzheimer's disease, vascular cognitive impairment) vs. normal 
      cognition (NC). Between-group standardized mean differences (SMD) were summarized 
      in random effects meta-analyses. From 2108 records, data were combined 
      quantitatively from 40 studies. Concentrations of interleukin-6 (IL-6; 
      N(CI)/N(NC) = 934/3154, SMD 0.74 95% confidence interval [0.07, 1.42], 
      Z(5) = 2.15, p = 0.03; I(2) = 98.08%), C-reactive protein (CRP; 
      N(CI)/N(NC) = 1610/4363, SMD 0.80 [0.50, 1.11], Z(14) = 5.25, p < 0.01; 
      I(2) = 94.59%), soluble vascular cell adhesion molecule-1 (sVCAM-1; 
      N(CI)/N(NC) = 104/1063, SMD 1.64 95% confidence interval [0.21, 3.07], 
      Z(2) = 2.25, p = 0.02; I(2) = 95.19%), and advanced glycation end products (AGEs; 
      N(CI)/N(NC) = 227/317, SMD 0.84 95% confidence interval [0.41, 1.27], 
      Z(2) = 3.82, p < 0.01; I(2) = 81.07%) were higher among CI groups compared to NC. 
      Brain derived neurotropic factor (BDNF) concentrations were significantly lower 
      in CI compared to NC (N(CI)/N(NC) = 848/2063, SMD -0.67 95% confidence interval 
      [-0.99, -0.35], Z(3) = -4.09, p < 0.01; I(2) = 89.20%). Cognitive impairment 
      among people with T2DM was associated with systemic inflammation and lower BDNF 
      concentrations. These inflammatory characteristics support an increased 
      inflammatory-vascular interaction associated with cognitive impairment in T2DM. 
      PROSPERO (CRD42020188625).
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Anita, Natasha Z
AU  - Anita NZ
AD  - Department of Pharmacology & Toxicology - University of Toronto, Medical Sciences 
      Building, 1 King's College Circle Room 4207, Toronto, Ontario M5S 1A8, Canada; 
      Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, 
      Canada; University Health Network Toronto Rehabilitation Institute - Rumsey 
      Centre Cardiac Rehabilitation, 347 Rumsey Rd, East York, Ontario M4G 2V6, Canada.
FAU - Zebarth, Julia
AU  - Zebarth J
AD  - Department of Pharmacology & Toxicology - University of Toronto, Medical Sciences 
      Building, 1 King's College Circle Room 4207, Toronto, Ontario M5S 1A8, Canada; 
      Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, 
      Canada; University Health Network Toronto Rehabilitation Institute - Rumsey 
      Centre Cardiac Rehabilitation, 347 Rumsey Rd, East York, Ontario M4G 2V6, Canada.
FAU - Chan, Brian
AU  - Chan B
AD  - Department of Pharmacology & Toxicology - University of Toronto, Medical Sciences 
      Building, 1 King's College Circle Room 4207, Toronto, Ontario M5S 1A8, Canada.
FAU - Wu, Che-Yuan
AU  - Wu CY
AD  - Department of Pharmacology & Toxicology - University of Toronto, Medical Sciences 
      Building, 1 King's College Circle Room 4207, Toronto, Ontario M5S 1A8, Canada; 
      Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, 
      Canada.
FAU - Syed, Taha
AU  - Syed T
AD  - Department of Pharmacology & Toxicology - University of Toronto, Medical Sciences 
      Building, 1 King's College Circle Room 4207, Toronto, Ontario M5S 1A8, Canada.
FAU - Shahrul, Dinie
AU  - Shahrul D
AD  - Department of Pharmacology & Toxicology - University of Toronto, Medical Sciences 
      Building, 1 King's College Circle Room 4207, Toronto, Ontario M5S 1A8, Canada.
FAU - Nguyen, Michelle M
AU  - Nguyen MM
AD  - Department of Pharmacology & Toxicology - University of Toronto, Medical Sciences 
      Building, 1 King's College Circle Room 4207, Toronto, Ontario M5S 1A8, Canada; 
      Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, 
      Canada; University Health Network Toronto Rehabilitation Institute - Rumsey 
      Centre Cardiac Rehabilitation, 347 Rumsey Rd, East York, Ontario M4G 2V6, Canada.
FAU - Pakosh, Maureen
AU  - Pakosh M
AD  - Library & Information Services, University Health Network- Toronto Rehabilitation 
      Institute, Toronto, Ontario, Canada.
FAU - Herrmann, Nathan
AU  - Herrmann N
AD  - Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, 
      Canada.
FAU - Lanctot, Krista L
AU  - Lanctot KL
AD  - Department of Pharmacology & Toxicology - University of Toronto, Medical Sciences 
      Building, 1 King's College Circle Room 4207, Toronto, Ontario M5S 1A8, Canada; 
      Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, 
      Canada; University Health Network Toronto Rehabilitation Institute - Rumsey 
      Centre Cardiac Rehabilitation, 347 Rumsey Rd, East York, Ontario M4G 2V6, Canada.
FAU - Swardfager, Walter
AU  - Swardfager W
AD  - Department of Pharmacology & Toxicology - University of Toronto, Medical Sciences 
      Building, 1 King's College Circle Room 4207, Toronto, Ontario M5S 1A8, Canada; 
      Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, 
      Canada; University Health Network Toronto Rehabilitation Institute - Rumsey 
      Centre Cardiac Rehabilitation, 347 Rumsey Rd, East York, Ontario M4G 2V6, Canada. 
      Electronic address: w.swardfager@utoronto.ca.
LA  - eng
GR  - PJT-159711/CIHR/Canada
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20211120
PL  - Netherlands
TA  - Brain Behav Immun
JT  - Brain, behavior, and immunity
JID - 8800478
RN  - 0 (Biomarkers)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - *Alzheimer Disease/etiology
MH  - Biomarkers
MH  - C-Reactive Protein/analysis
MH  - *Cognitive Dysfunction/etiology
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Humans
EDAT- 2021/11/23 06:00
MHDA- 2022/03/15 06:00
CRDT- 2021/11/22 20:16
PHST- 2021/06/10 00:00 [received]
PHST- 2021/11/01 00:00 [revised]
PHST- 2021/11/13 00:00 [accepted]
PHST- 2021/11/23 06:00 [pubmed]
PHST- 2022/03/15 06:00 [medline]
PHST- 2021/11/22 20:16 [entrez]
AID - S0889-1591(21)00601-2 [pii]
AID - 10.1016/j.bbi.2021.11.005 [doi]
PST - ppublish
SO  - Brain Behav Immun. 2022 Feb;100:55-69. doi: 10.1016/j.bbi.2021.11.005. Epub 2021 
      Nov 20.