PMID- 34808547
OWN - NLM
STAT- MEDLINE
DCOM- 20211229
LR  - 20211229
IS  - 1532-2688 (Electronic)
IS  - 1059-1311 (Linking)
VI  - 94
DP  - 2022 Jan
TI  - Elderly patients with nonconvulsive status epilepticus: Clinical-EEG data, 
      hospital mortality, STESS and EMSE.
PG  - 18-22
LID - S1059-1311(21)00356-3 [pii]
LID - 10.1016/j.seizure.2021.11.004 [doi]
AB  - Purpose To assess the clinical-EEG aspects, characterization of subtypes, 
      relationships with prognostic scales and the occurrence of death in elderly 
      patients in the acute phase of nonconvulsive status epilepticus (NCSE). 
      Methodology Clinical variables, EEG data, Status epilepticus severity score 
      (STESS), and the Epidemiology-based mortality score in status epilepticus (EMSE) 
      were related to the death of 96 patients who were over 60 years old, with NCSE. 
      Results NCSE with coma was observed in 31 patients (19 non-subtle and 12 "subtle" 
      SE) and focal NCSE with impairment of consciousness in 65 cases. There were no 
      significant EEG differences according to the type of NCSE. Higher STESS scores 
      occurred in the comatose NCSE patients when compared to those with focal NCSE and 
      impairment of consciousness (4.8 +/- 1.2 vs 3.7 +/- 1.2; T-Test; p<0.001). It was 
      observed that 25 (26%) elderly died, with a mean survival time of 19.3 days. 
      Elderly people with a higher risk of death are those diagnosed with NCSE with 
      coma (HR 2.76; 95% CI 1.15-6.65; p = 0.023), with STESS>/=3 (HR 16.0; CI 
      1.77-45.08; p = 0.014), with EMSE>/=64 (HR 3.67; CI 1.54-8.72; p = 0.003), and 
      those with no history of recurrent SE (HR 6.80; CI 1.42-32.64; p = 0.017), in Cox 
      regression. Conclusion The ictal EEG patterns did not distinguish the subtypes of 
      NCSE. Thirty-day mortality rate was high in elderly patients with NCSE. The 
      clinical variables are related to prognosis. Mortality in the elderly was 
      associated with comatose NCSE patients, with STESS>/=3, with EMSE>/=64, and no 
      history of recurrent SE.
CI  - Copyright (c) 2021. Published by Elsevier Ltd.
FAU - Tedrus, Gloria Mas
AU  - Tedrus GM
AD  - Postgraduate Program in Health Sciences, PUC-Campinas. Electronic address: 
      gmtedrus@uol.com.br.
FAU - Nogueira, Elizardo Junior
AU  - Nogueira E Junior
AD  - Clinical Neurology Service - University Hospital, PUC-Campinas.
FAU - Vidal, Mariana Almeida
AU  - Vidal MA
AD  - Clinical Neurology Service - University Hospital, PUC-Campinas.
LA  - eng
PT  - Journal Article
DEP - 20211111
PL  - England
TA  - Seizure
JT  - Seizure
JID - 9306979
SB  - IM
MH  - Aged
MH  - Electroencephalography
MH  - Hospital Mortality
MH  - Humans
MH  - Middle Aged
MH  - Prognosis
MH  - Severity of Illness Index
MH  - *Status Epilepticus/diagnosis/epidemiology
OTO - NOTNLM
OT  - EEG
OT  - Elderly
OT  - Mortality
OT  - Non-convulsive status epilepticus
EDAT- 2021/11/23 06:00
MHDA- 2021/12/30 06:00
CRDT- 2021/11/22 20:25
PHST- 2021/09/10 00:00 [received]
PHST- 2021/10/18 00:00 [revised]
PHST- 2021/11/08 00:00 [accepted]
PHST- 2021/11/23 06:00 [pubmed]
PHST- 2021/12/30 06:00 [medline]
PHST- 2021/11/22 20:25 [entrez]
AID - S1059-1311(21)00356-3 [pii]
AID - 10.1016/j.seizure.2021.11.004 [doi]
PST - ppublish
SO  - Seizure. 2022 Jan;94:18-22. doi: 10.1016/j.seizure.2021.11.004. Epub 2021 Nov 11.