PMID- 34811582
OWN - NLM
STAT- MEDLINE
DCOM- 20220228
LR  - 20220228
IS  - 1432-1041 (Electronic)
IS  - 0031-6970 (Linking)
VI  - 78
IP  - 3
DP  - 2022 Mar
TI  - No association between acid suppressant use and risk of dementia: an updated 
      meta-analysis.
PG  - 375-382
LID - 10.1007/s00228-021-03248-0 [doi]
AB  - PURPOSE: Findings from large observational studies on whether the use of acid 
      suppressants increases the risk of dementia have been inconsistent. Since proton 
      pump inhibitors (PPI) and histamine-2 receptor antagonists (H2RA) are the most 
      commonly used acid suppressants in clinical practice, we performed a 
      meta-analysis to examine the influence of PPI and H2RA on the risk of dementia. 
      METHODS: A systematic search was performed on the PubMed, EMBASE, and Cochrane 
      Library databases to identify studies published up to April, 2021. Studies that 
      reported adjusted hazard ratio (HR) with 95% confidence intervals (CI) for the 
      associations of interest were included. Data in the included studies were pooled 
      using the random-effects model for meta-analysis. Statistical analysis was 
      performed using Stata version 12.0 software. RESULTS: Seventeen studies involving 
      1,251,562 participants were included. It was found that PPI users were not likely 
      to develop dementia compared with those not taking PPI (HR = 0.98, 95% CI: 
      0.85-1.13). Subgroup analysis based on publication year, location, mean age, 
      duration of PPI use, and female proportion also revealed no association between 
      PPI use and dementia risk. Similarly, H2RA use was not associated with the risk 
      of dementia, as indicated by the pooled HR of 1.20 (95% CI: 0.98-1.47). 
      CONCLUSION: Results of this meta-analysis suggest that PPI and H2RA do not 
      increase the risk of dementia. These results may be used to inform the clinical 
      application of acid suppressants. However, further randomized controlled trials 
      are needed to confirm the present conclusions.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Wang, Hengmin
AU  - Wang H
AD  - Associate Chief of Physician, Internal Medicine Neurology, Wuhan Red Cross 
      Hospital, Wuhan, 430015, HB, China.
FAU - Tian, Liang
AU  - Tian L
AD  - Department of Urology, Wuhan Red Cross Hospital, Wuhan, 430015, HB, China.
FAU - Yan, Xiaohong
AU  - Yan X
AUID- ORCID: 0000-0001-6836-9240
AD  - Geriatric Medicine, Wuhan Red Cross Hospital, Wuhan, 430015, HB, China. 
      mind24@163.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20211122
PL  - Germany
TA  - Eur J Clin Pharmacol
JT  - European journal of clinical pharmacology
JID - 1256165
RN  - 0 (Histamine H2 Antagonists)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Dementia/*epidemiology
MH  - Female
MH  - Histamine H2 Antagonists/*administration & dosage
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Observational Studies as Topic
MH  - Proton Pump Inhibitors/*administration & dosage
MH  - Risk Factors
MH  - Sex Factors
OTO - NOTNLM
OT  - Dementia
OT  - Histamine-2 receptor antagonist
OT  - Meta-analysis
OT  - Proton pump inhibitors
EDAT- 2021/11/24 06:00
MHDA- 2022/03/01 06:00
CRDT- 2021/11/23 06:38
PHST- 2021/08/23 00:00 [received]
PHST- 2021/10/29 00:00 [accepted]
PHST- 2021/11/24 06:00 [pubmed]
PHST- 2022/03/01 06:00 [medline]
PHST- 2021/11/23 06:38 [entrez]
AID - 10.1007/s00228-021-03248-0 [pii]
AID - 10.1007/s00228-021-03248-0 [doi]
PST - ppublish
SO  - Eur J Clin Pharmacol. 2022 Mar;78(3):375-382. doi: 10.1007/s00228-021-03248-0. 
      Epub 2021 Nov 22.