PMID- 34812516
OWN - NLM
STAT- MEDLINE
DCOM- 20220328
LR  - 20220328
IS  - 1097-4644 (Electronic)
IS  - 0730-2312 (Linking)
VI  - 123
IP  - 2
DP  - 2022 Feb
TI  - Genes controlling skeletal muscle glucose uptake and their regulation by 
      endurance and resistance exercise.
PG  - 202-214
LID - 10.1002/jcb.30179 [doi]
AB  - Exercise improves the insulin sensitivity of glucose uptake in skeletal muscle. 
      Due to that, exercise has become a cornerstone treatment for type 2 diabetes 
      mellitus (T2DM). The mechanisms by which exercise improves skeletal muscle 
      insulin sensitivity are, however, incompletely understood. We conducted a 
      systematic review to identify all genes whose gain or loss of function alters 
      skeletal muscle glucose uptake. We subsequently cross-referenced these genes with 
      recently generated data sets on exercise-induced gene expression and signaling. 
      Our search revealed 176 muscle glucose-uptake genes, meaning that their genetic 
      manipulation altered glucose uptake in skeletal muscle. Notably, exercise 
      regulates the expression or phosphorylation of more than 50% of the 
      glucose-uptake genes or their protein products. This included many genes that 
      previously have not been associated with exercise-induced insulin sensitivity. 
      Interestingly, endurance and resistance exercise triggered some common but mostly 
      unique changes in expression and phosphorylation of glucose-uptake genes or their 
      protein products. Collectively, our work provides a resource of potentially new 
      molecular effectors that play a role in the incompletely understood regulation of 
      muscle insulin sensitivity by exercise.
CI  - (c) 2021 The Authors. Journal of Cellular Biochemistry published by Wiley 
      Periodicals LLC.
FAU - Verbrugge, Sander A J
AU  - Verbrugge SAJ
AUID- ORCID: 0000-0001-7531-7879
AD  - Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz 
      Zentrum Munchen, Neuherberg, Germany.
AD  - Exercise Biology Group, Department for Sport and Health Sciences, Technical 
      University of Munich, Munich, Germany.
FAU - Alhusen, Julia A
AU  - Alhusen JA
AD  - Molecular Endocrinology, Institute for Diabetes and Cancer (IDC), Helmholtz 
      Zentrum Munich, Helmholtz Diabetes Center (HMGU), Munich, Germany.
FAU - Kempin, Shimon
AU  - Kempin S
AD  - Exercise Biology Group, Department for Sport and Health Sciences, Technical 
      University of Munich, Munich, Germany.
FAU - Pillon, Nicolas J
AU  - Pillon NJ
AUID- ORCID: 0000-0003-1107-9490
AD  - Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, 
      Sweden.
FAU - Rozman, Jan
AU  - Rozman J
AD  - Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech 
      Academy of Sciences, Vestec, Czech Republic.
FAU - Wackerhage, Henning
AU  - Wackerhage H
AD  - Exercise Biology Group, Department for Sport and Health Sciences, Technical 
      University of Munich, Munich, Germany.
FAU - Kleinert, Maximilian
AU  - Kleinert M
AUID- ORCID: 0000-0002-8069-9055
AD  - Muscle Physiology and Metabolism Group, German Institute of Human Nutrition, 
      Potsdam - Rehbrucke, Nuthetal, Germany.
AD  - Department of Nutrition, Exercise and Sports, Faculty of Science, Section of 
      Molecular Physiology, University of Copenhagen, Copenhagen, Denmark.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20211123
PL  - United States
TA  - J Cell Biochem
JT  - Journal of cellular biochemistry
JID - 8205768
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Animals
MH  - *Blood Glucose/genetics/metabolism
MH  - *Diabetes Mellitus, Type 2/genetics/metabolism
MH  - Humans
MH  - Insulin Resistance/*genetics
MH  - Muscle, Skeletal/*metabolism
MH  - Physical Endurance/*genetics
MH  - *Resistance Training
OTO - NOTNLM
OT  - exercise metabolism
OT  - glucose uptake
OT  - insulin sensitivity
OT  - insulin signaling
OT  - resistance and endurance exercise
OT  - skeletal muscle
EDAT- 2021/11/24 06:00
MHDA- 2022/03/29 06:00
CRDT- 2021/11/23 09:35
PHST- 2021/10/27 00:00 [revised]
PHST- 2021/06/02 00:00 [received]
PHST- 2021/11/04 00:00 [accepted]
PHST- 2021/11/24 06:00 [pubmed]
PHST- 2022/03/29 06:00 [medline]
PHST- 2021/11/23 09:35 [entrez]
AID - 10.1002/jcb.30179 [doi]
PST - ppublish
SO  - J Cell Biochem. 2022 Feb;123(2):202-214. doi: 10.1002/jcb.30179. Epub 2021 Nov 
      23.