PMID- 34812800
OWN - NLM
STAT- MEDLINE
DCOM- 20211207
LR  - 20211214
IS  - 1364-5528 (Electronic)
IS  - 0003-2654 (Linking)
VI  - 146
IP  - 24
DP  - 2021 Dec 6
TI  - Development of laser ablation dielectric barrier discharge optical emission 
      spectrometry (LA-DBD-OES) for direct determination of sulphur and chloride in the 
      condensed phase and its application in pharmaceutical analysis.
PG  - 7537-7544
LID - 10.1039/d1an01563j [doi]
AB  - An infrared laser (808 nm) has been coupled with dielectric barrier discharge 
      (DBD) for optical emission spectrometric determination of S and Cl in organic 
      compounds. The use of a continuous wave IR laser with an output power of 1-2 W 
      allows volatilization of analytes from condensed surfaces. Analytes thermally 
      delivered to the gas phase are excited and atomized by the DBD plasma triggered 
      by an alternating voltage of 10 kV at 25 kHz under atmospheric pressure. Direct 
      analysis of S- and Cl-containing organics in manufactured tablets by measuring 
      the S and Cl emissions resulted in a dynamic range of 0.5%-20% with linearities 
      (R(2)) above 0.93 and limits of detection (LODs) in the mug g(-1) range. The 
      detection precision was examined by measuring inter-day and intra-day 
      reproducibilities, leading to relative standard deviations (RSDs) ranging from 
      4.6% to 15.0%. The feasibility of LA-DBD-OES was further demonstrated with 
      commercial pharmaceutical tablets of sulfadiazine (SDZ) and chloramphenicol 
      (CAP). There is the potential for probing the tablet uniformity by monitoring the 
      elemental emissions of S and Cl. Quantitative results of the commercial tablets 
      were consistent with the indication amounts and were verified by HPLC 
      measurements. All these results suggest the proposed methodology as a promising 
      tool for online analysis of solids and pharmaceutical tablets with minimal sample 
      treatments and rapid detection response.
FAU - Ding, Xuelu
AU  - Ding X
AUID- ORCID: 0000-0001-5886-6198
AD  - Department of Pharmaceutical Analysis, School of Pharmacy, Qingdao University, 
      No. 1 Ningde Road, 266071, Qingdao, China. xueluding@qdu.edu.cn.
FAU - Geng, Chaoqun
AU  - Geng C
AD  - Department of Pharmaceutical Analysis, School of Pharmacy, Qingdao University, 
      No. 1 Ningde Road, 266071, Qingdao, China. xueluding@qdu.edu.cn.
FAU - Zhai, Suhan
AU  - Zhai S
AD  - Department of Pharmaceutical Analysis, School of Pharmacy, Qingdao University, 
      No. 1 Ningde Road, 266071, Qingdao, China. xueluding@qdu.edu.cn.
FAU - Cao, Xiaoyan
AU  - Cao X
AD  - Department of Pharmaceutical Analysis, School of Pharmacy, Qingdao University, 
      No. 1 Ningde Road, 266071, Qingdao, China. xueluding@qdu.edu.cn.
FAU - Shi, Zhenyan
AU  - Shi Z
AD  - Department of Pharmaceutical Analysis, School of Pharmacy, Qingdao University, 
      No. 1 Ningde Road, 266071, Qingdao, China. xueluding@qdu.edu.cn.
FAU - Liu, Kun
AU  - Liu K
AD  - Department of Pharmaceutical Analysis, School of Pharmacy, Qingdao University, 
      No. 1 Ningde Road, 266071, Qingdao, China. xueluding@qdu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20211206
PL  - England
TA  - Analyst
JT  - The Analyst
JID - 0372652
RN  - 0 (Chlorides)
RN  - 0 (Pharmaceutical Preparations)
RN  - 70FD1KFU70 (Sulfur)
SB  - IM
MH  - Chlorides
MH  - *Laser Therapy
MH  - *Pharmaceutical Preparations
MH  - Spectrum Analysis
MH  - Sulfur
EDAT- 2021/11/24 06:00
MHDA- 2021/12/15 06:00
CRDT- 2021/11/23 12:19
PHST- 2021/11/24 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/11/23 12:19 [entrez]
AID - 10.1039/d1an01563j [doi]
PST - epublish
SO  - Analyst. 2021 Dec 6;146(24):7537-7544. doi: 10.1039/d1an01563j.