PMID- 34813847
OWN - NLM
STAT- MEDLINE
DCOM- 20220126
LR  - 20220126
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 291
IP  - Pt 2
DP  - 2022 Mar
TI  - The association of aldehydes exposure with diabetes mellitus in US population: 
      NHANES 2013-2014.
PG  - 133019
LID - S0045-6535(21)03491-3 [pii]
LID - 10.1016/j.chemosphere.2021.133019 [doi]
AB  - BACKGROUND: The association of mixed aldehydes exposure with diabetes remains 
      unclear. OBJECTIVE: We aimed to explore associations between serum aldehydes 
      concentration and diabetes. METHODS: We analyzed associations between aldehydes 
      and diabetes using data from 1795 participants in the National Health and 
      Nutrition Examination Survey (NHANES) from 2013 to 2014 by multiple logistic 
      regression models. Bayesian kernel machine regression (BKMR) was used to evaluate 
      the combined association of serum aldehydes on prediabetes and diabetes. RESULTS: 
      Isopentanaldehyde increased the risk of diabetes 2.09 fold (95%CI:1.05-4.16) in 
      the highest tertile, compared to the lowest-tertile concentration after adjusting 
      for covariates, with a p-value for trend (P-t) equal to 0.041, in females. The 
      adjusted OR of prediabetes with a 95% CI for the highest tertile was 0.52(0.28, 
      0.97) for benzaldehyde in females (P-t = 0.034). We also found associations in 
      the male group between butyraldehyde and diabetes for the second (OR:2.80, 
      95%CI:1.35-5.79) and third (OR:2.59, 95%CI:1.30-5.17) tertile levels 
      (P-t = 0.010). The risk of diabetes increased 2.55 fold (95%CI: 1.26-5.16, 
      P-t = 0.008), in subjects in the highest tertile of hexanaldehyde concentration. 
      Other aldehydes did not show a statistically significant association with 
      diabetes or prediabetes. The BKMR model showed a positive association of mixed 
      aldehydes with diabetes in males, and butyraldehyde showed a significant positive 
      trend with the highest posterior inclusion probability (PIP = 0.85). Mixed 
      aldehydes increased female's risk from prediabetes to diabetes in which 
      isopentanaldehyde had the highest posterior inclusion probability (PIP = 0.67). 
      CONCLUSIONS: The mixed aldehydes might increase the risk of suffering from 
      diabetes in males and accelerate the progression of diabetes in females, in which 
      butyraldehyde and isopentanaldehyde play the most important roles.
CI  - Copyright (c) 2021. Published by Elsevier Ltd.
FAU - Weng, Xueqiong
AU  - Weng X
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No.601 Huangpu Ave West, Guangzhou, 510632, Guangdong, China.
FAU - Chen, Jingmin
AU  - Chen J
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No.601 Huangpu Ave West, Guangzhou, 510632, Guangdong, China.
FAU - Fei, Qiaoyuan
AU  - Fei Q
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No.601 Huangpu Ave West, Guangzhou, 510632, Guangdong, China.
FAU - Guo, Xinrong
AU  - Guo X
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No.601 Huangpu Ave West, Guangzhou, 510632, Guangdong, China.
FAU - Liu, Shan
AU  - Liu S
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No.601 Huangpu Ave West, Guangzhou, 510632, Guangdong, China.
FAU - Wen, Lin
AU  - Wen L
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No.601 Huangpu Ave West, Guangzhou, 510632, Guangdong, China.
FAU - Liang, Huanzhu
AU  - Liang H
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No.601 Huangpu Ave West, Guangzhou, 510632, Guangdong, China.
FAU - Guo, Congcong
AU  - Guo C
AD  - Jiaojiang Center for Disease Control and Prevention, Taizhou, Zhejiang Province, 
      China.
FAU - Nie, Lihong
AU  - Nie L
AD  - Department of Endocrine, The First Affiliated Hospital of Jinan University, 
      Guangzhou, China.
FAU - Jing, Chunxia
AU  - Jing C
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No.601 Huangpu Ave West, Guangzhou, 510632, Guangdong, China; 
      Guangdong Key Laboratory of Environmental Exposure and Health, Jinan University, 
      Guangzhou, 510632, Guangdong, China. Electronic address: jcxphd@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20211120
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Aldehydes)
SB  - IM
MH  - Aldehydes
MH  - Bayes Theorem
MH  - *Diabetes Mellitus/epidemiology
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Nutrition Surveys
MH  - *Prediabetic State/epidemiology
OTO - NOTNLM
OT  - Aldehydes
OT  - BKMR
OT  - Butyraldehyde
OT  - Diabetes
OT  - Isopentanaldehyde
EDAT- 2021/11/24 06:00
MHDA- 2022/01/27 06:00
CRDT- 2021/11/23 20:13
PHST- 2021/05/23 00:00 [received]
PHST- 2021/10/11 00:00 [revised]
PHST- 2021/11/19 00:00 [accepted]
PHST- 2021/11/24 06:00 [pubmed]
PHST- 2022/01/27 06:00 [medline]
PHST- 2021/11/23 20:13 [entrez]
AID - S0045-6535(21)03491-3 [pii]
AID - 10.1016/j.chemosphere.2021.133019 [doi]
PST - ppublish
SO  - Chemosphere. 2022 Mar;291(Pt 2):133019. doi: 10.1016/j.chemosphere.2021.133019. 
      Epub 2021 Nov 20.