PMID- 34814530
OWN - NLM
STAT- MEDLINE
DCOM- 20211125
LR  - 20211125
IS  - 0254-6450 (Print)
IS  - 0254-6450 (Linking)
VI  - 42
IP  - 7
DP  - 2021 Jul 10
TI  - [Association between body mass index changes and other risk factors for 
      cardiovascular disease in patients with type 2 diabetes mellitus].
PG  - 1194-1199
LID - 10.3760/cma.j.cn112338-20200615-00841 [doi]
AB  - Objectives: To investigate the association between body mass index (BMI) changes 
      and other risk factors for cardiovascular disease in patients with type 2 
      diabetes mellitus (T2DM). Methods: Based on the T2DM cohort in rural communities 
      of Zhejiang province, baseline and follow up information of height, weight, blood 
      pressure, glycated hemoglobin (HbA1c), TC, TG, LDL-C and HDL-C of the T2DM 
      patients were collected. After excluding those who died during the follow-up 
      period, lost follow-up or had incomplete information, a total of 8 953 T2DM 
      patients were included in the final analysis. Multiple linear regression and Cox 
      proportional hazards regression models were used for analysis. Results: At 
      baseline survey, 40.97% of the T2DM patients were overweight and obese. Compared 
      with those with normal BMI, the SBP, DBP and TG level were significantly higher, 
      while HDL-C level was significantly lower in the overweight and obese T2DM 
      patients (P<0.01). During the follow-up period, the blood glucose control rate in 
      the patients increased by 15%, and the levels of HbA1c decreased in the patients 
      with different BMI changes at different degrees. Compared with the patients who 
      kept normal BMI, the HbA1c level decrease had a smaller range, while the SBP and 
      DBP increase had a larger range in the patients with persistent overweight and 
      obesity, and their substandard rates of HbA1c, SBP, DBP, TG, HDL-C levels were 
      1.142 (1.057-1.233) times, 1.123 (1.055-1.196) times, 1.220 (1.128-1.320) times, 
      1.400 (1.282-1.528) times and 1.164 (1.069-1.267) times higher. The changes of 
      blood pressure, blood lipids and other related indicators in the patients whose 
      BMI became abnormal were similar to those of the patients with persistent 
      overweight and obesity; Compared with the patients whose BMI were kept normal, 
      the differences in changes and substandard rate of blood glucose level, blood 
      pressure level in the patients whose BMI became normal were not significant 
      (P>0.05). The change value of BMI was positively correlated with the change value 
      of SBP, DBP, TG and LDL-C, while negatively correlated with the change value of 
      HDL-C (P<0.05). Conclusions: Abnormal changes in BMI are associated with the 
      adverse changes of blood glucose level, blood pressure, and blood lipids level 
      and other cardiovascular disease risk factors. Keeping normal BMI would benefit 
      the positive outcome of cardiovascular adverse factors.
FAU - Hu, R Y
AU  - Hu RY
AD  - Department of Chronic and Non-communicable Disease Prevention and Control, 
      Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, 
      China.
FAU - He, Q F
AU  - He QF
AD  - Department of Chronic and Non-communicable Disease Prevention and Control, 
      Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, 
      China.
FAU - Pan, J
AU  - Pan J
AD  - Department of Chronic and Non-communicable Disease Prevention and Control, 
      Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, 
      China.
FAU - Wang, M
AU  - Wang M
AD  - Department of Chronic and Non-communicable Disease Prevention and Control, 
      Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, 
      China.
FAU - Zhou, X Y
AU  - Zhou XY
AD  - Department of Chronic and Non-communicable Disease Prevention and Control, 
      Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, 
      China.
FAU - Yu, M
AU  - Yu M
AD  - Department of Chronic and Non-communicable Disease Prevention and Control, 
      Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, 
      China.
LA  - chi
GR  - 2016YFC0901200, 2016YFC0901205/National Key Research and Development Program of 
      China/
GR  - 2017C33090/Zhejiang Provincial Research Fund for Application of Public Interest 
      Technology/
PT  - Journal Article
PL  - China
TA  - Zhonghua Liu Xing Bing Xue Za Zhi
JT  - Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
JID - 8208604
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Blood Glucose
MH  - Body Mass Index
MH  - *Cardiovascular Diseases/epidemiology
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - Heart Disease Risk Factors
MH  - Humans
MH  - Risk Factors
EDAT- 2021/11/25 06:00
MHDA- 2021/11/26 06:00
CRDT- 2021/11/24 02:19
PHST- 2021/11/24 02:19 [entrez]
PHST- 2021/11/25 06:00 [pubmed]
PHST- 2021/11/26 06:00 [medline]
AID - 10.3760/cma.j.cn112338-20200615-00841 [doi]
PST - ppublish
SO  - Zhonghua Liu Xing Bing Xue Za Zhi. 2021 Jul 10;42(7):1194-1199. doi: 
      10.3760/cma.j.cn112338-20200615-00841.