PMID- 34814962
OWN - NLM
STAT- MEDLINE
DCOM- 20220811
LR  - 20240202
IS  - 1475-2727 (Electronic)
IS  - 1368-9800 (Print)
IS  - 1368-9800 (Linking)
VI  - 25
IP  - 9
DP  - 2022 Sep
TI  - Maternal carbohydrate intake during pregnancy is associated with child 
      peripubertal markers of metabolic health but not adiposity.
PG  - 2541-2553
LID - 10.1017/S1368980021004614 [doi]
AB  - OBJECTIVE: To examine the associations of trimester-specific maternal prenatal 
      carbohydrate (CHO) intake with offspring adiposity and metabolic health during 
      peripuberty. DESIGN: Prospective cohort study in which maternal dietary intake 
      was collected via validated FFQ during each trimester. Offspring adiposity and 
      metabolic biomarkers were evaluated at age 8-14 years. We used multivariable 
      linear regression to examine associations between total energy-adjusted maternal 
      CHO intake and offspring BMI z-score, skinfold thickness and metabolic syndrome 
      risk z-score calculated as the average of waist circumference, fasting glucose, 
      fasting C-peptide, TAG:HDL and systolic blood pressure + diastolic blood 
      pressure/2. SETTING: Mexico City, Mexico. PARTICIPANTS: 237 mother-child pairs in 
      the Early Life Exposure in Mexico to Environmental Toxicants cohort. RESULTS: We 
      found non-linear associations of maternal CHO intake during pregnancy with 
      offspring metabolic health during peripuberty. After adjusting for maternal age, 
      and child age, sex and pubertal status, children whose mothers were in the fourth 
      v. first quartile of total CHO intake during the third trimester had 0.42 (95 % 
      CI -0.01, 0.08) ng/ml lower C-peptide and 0.10 (95 % CI -0.02, 0.22) units lower 
      C-peptide insulin resistance (CP-IR). We found similar magnitude and direction of 
      association with respect to net CHO intake during the first trimester and 
      offspring C-peptide and CP-IR. Maternal CHO intake during pregnancy was not 
      associated with offspring adiposity. CONCLUSIONS: In this study of mother-child 
      pairs in Mexico City, children born to women in the highest quartile of CHO 
      intake during pregnancy had lowest C-peptide and CP-IR during peripuberty. 
      Additional research is warranted to replicate and identify mechanisms.
FAU - Mulcahy, Molly C
AU  - Mulcahy MC
AUID- ORCID: 0000-0002-8903-7357
AD  - Department of Nutritional Sciences, University of Michigan School of Public 
      Health, Ann Arbor, MI, USA.
FAU - Tellez-Rojo, Martha Maria
AU  - Tellez-Rojo MM
AD  - Center for Nutrition and Health Research, Instituto de Salud Publica, Cuernavaca, 
      Morelos, Mexico.
FAU - Cantoral, Alejandra
AU  - Cantoral A
AD  - Department of Health, Universidad Iberoamericana, Prolongacion Paseo de Reforma 
      880, Lomas de Santa Fe, Ciudad de Mexico, C.P. 01219, Mexico.
FAU - Solano-Gonzalez, Maritsa
AU  - Solano-Gonzalez M
AD  - Center for Nutrition and Health Research, Instituto de Salud Publica, Cuernavaca, 
      Morelos, Mexico.
FAU - Baylin, Ana
AU  - Baylin A
AD  - Department of Nutritional Sciences, University of Michigan School of Public 
      Health, Ann Arbor, MI, USA.
AD  - Department of Epidemiology, University of Michigan School of Public Health, Ann 
      Arbor, MI, USA.
FAU - Bridges, Dave
AU  - Bridges D
AD  - Department of Nutritional Sciences, University of Michigan School of Public 
      Health, Ann Arbor, MI, USA.
FAU - Peterson, Karen E
AU  - Peterson KE
AD  - Department of Nutritional Sciences, University of Michigan School of Public 
      Health, Ann Arbor, MI, USA.
AD  - Department of Epidemiology, University of Michigan School of Public Health, Ann 
      Arbor, MI, USA.
AD  - Department of Environmental Health Sciences, University of Michigan School of 
      Public Health, Ann Arbor, MI, USA.
FAU - Perng, Wei
AU  - Perng W
AD  - Department of Nutritional Sciences, University of Michigan School of Public 
      Health, Ann Arbor, MI, USA.
AD  - Department of Epidemiology, Colorado School of Public Health, Anschutz Medical 
      Campus, Aurora, CO, USA.
LA  - eng
GR  - R01 ES014930/ES/NIEHS NIH HHS/United States
GR  - P30 DK048520/DK/NIDDK NIH HHS/United States
GR  - R01 DK107535/DK/NIDDK NIH HHS/United States
GR  - P30 ES017885/ES/NIEHS NIH HHS/United States
GR  - KL2 TR002534/TR/NCATS NIH HHS/United States
GR  - P01 ES022844/ES/NIEHS NIH HHS/United States
GR  - R01 ES013744/ES/NIEHS NIH HHS/United States
GR  - P20 ES018171/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20211124
PL  - England
TA  - Public Health Nutr
JT  - Public health nutrition
JID - 9808463
RN  - 0 (Biomarkers)
RN  - 0 (C-Peptide)
RN  - 0 (Carbohydrates)
SB  - IM
MH  - *Adiposity
MH  - Adolescent
MH  - Biomarkers
MH  - Body Mass Index
MH  - C-Peptide/metabolism
MH  - Carbohydrates
MH  - Child
MH  - Female
MH  - Humans
MH  - Obesity/metabolism
MH  - *Prenatal Exposure Delayed Effects
MH  - Prospective Studies
PMC - PMC9991622
OTO - NOTNLM
OT  - Adiposity
OT  - Adolescence
OT  - Carbohydrate
OT  - Childhood obesity
OT  - Metabolic health
OT  - Nutritional epidemiology
EDAT- 2021/11/25 06:00
MHDA- 2022/08/12 06:00
PMCR- 2023/03/07
CRDT- 2021/11/24 05:38
PHST- 2021/11/25 06:00 [pubmed]
PHST- 2022/08/12 06:00 [medline]
PHST- 2021/11/24 05:38 [entrez]
PHST- 2023/03/07 00:00 [pmc-release]
AID - S1368980021004614 [pii]
AID - 10.1017/S1368980021004614 [doi]
PST - ppublish
SO  - Public Health Nutr. 2022 Sep;25(9):2541-2553. doi: 10.1017/S1368980021004614. 
      Epub 2021 Nov 24.