PMID- 3481633
OWN - NLM
STAT- MEDLINE
DCOM- 19880418
LR  - 20191029
IS  - 0952-1178 (Print)
IS  - 0952-1178 (Linking)
VI  - 5
IP  - 4
DP  - 1987 Dec
TI  - Calcium antagonism and protection of tissues from calcium damage.
PG  - S37-42
AB  - Calcium antagonism of nifedipine, nitrendipine or nisoldipine prevented 
      salt-induced hypertension, renovascular damage and mortality in Dahl 
      salt-sensitive (S) rats. The calcium agonist BAY K 8644 accelerated the 
      development of salt-induced hypertension in S rats. In some S rats on a low-salt 
      diet BAY K 8644 induced renovascular damage without sustained hypertension. In 
      stroke-prone spontaneously hypertensive rats (SHRSP) on a normal diet the natural 
      appearance of stroke was correlated with an increased calcium content in brain 
      and kidney tissue. Nimodipine prevented stroke and the increase in brain calcium 
      content without affecting the high blood pressure. A similar protective effect 
      without substantial influence on high blood pressure was achieved by bilateral 
      parathyroidectomy. Hypertension-associated vascular damage does not necessarily 
      depend on the systemic intravascular pressure. In malignant hypertension the 
      deleterious calcium overload in tissues may be activated or inhibited 
      independently of the regulation of arterial blood pressure.
FAU - Kazda, S
AU  - Kazda S
AD  - Institute of Pharmacology, Bayer AG, Wuppertal, Federal Republic of Germany.
FAU - Grunt, M
AU  - Grunt M
FAU - Hirth, C
AU  - Hirth C
FAU - Preis, W
AU  - Preis W
FAU - Stasch, J P
AU  - Stasch JP
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - J Hypertens Suppl
JT  - Journal of hypertension. Supplement : official journal of the International 
      Society of Hypertension
JID - 8501422
RN  - 0 (Calcium Channel Blockers)
RN  - 451W47IQ8X (Sodium Chloride)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Calcium/metabolism/*toxicity
MH  - Calcium Channel Blockers/adverse effects/*therapeutic use
MH  - Drug Evaluation, Preclinical
MH  - Hypertension/etiology/metabolism/mortality/prevention & control
MH  - Male
MH  - Parathyroid Glands/physiology
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Sodium Chloride/administration & dosage
EDAT- 1987/12/01 00:00
MHDA- 1987/12/01 00:01
CRDT- 1987/12/01 00:00
PHST- 1987/12/01 00:00 [pubmed]
PHST- 1987/12/01 00:01 [medline]
PHST- 1987/12/01 00:00 [entrez]
AID - 10.1097/00004872-198712004-00007 [doi]
PST - ppublish
SO  - J Hypertens Suppl. 1987 Dec;5(4):S37-42. doi: 10.1097/00004872-198712004-00007.