PMID- 34817646 OWN - NLM STAT- MEDLINE DCOM- 20220221 LR - 20220221 IS - 1861-0692 (Electronic) IS - 1861-0684 (Linking) VI - 111 IP - 2 DP - 2022 Feb TI - Safety and efficacy of alcohol septal ablation in adolescents and young adults with hypertrophic obstructive cardiomyopathy. PG - 207-217 LID - 10.1007/s00392-021-01960-6 [doi] AB - INTRODUCTION: Data regarding alcohol septal ablation (ASA) in young patients with hypertrophic obstructive cardiomyopathy (HOCM) are scarce. The purpose of our study is to evaluate the safety and efficacy of ASA in patients 25 years (group 2). 1,264 procedures were analysed in group 2 (58.6 +/- 13.5 years) and 41 procedures in group 1 (20.9 +/- 3.3 years). The baseline interventricular septal diameter (IVSD) was higher in group 1 (26.0 +/- 6.5 mm vs. 21.3 +/- 4.4 mm; p < 0.0001). There was no difference in baseline left ventricular outflow tract gradient (LVOTG) (group 1: 54.4 +/- 24.4 mmHg; group 2: 52.4 +/- 36.6 mmHg; p = n.s.). A previous cardiac device was more often observed in group 1 (31.7% vs. 9.0%; p < 0.0001). Symptoms were improved after 6 months (group 1: mean NYHA class 2.5 at baseline and 1.3 at FU; p < 0.0001; group 2: mean NYHA class 2.7 at baseline and 1.4 at FU; p <0 .0001). IVSD (group 1: 20.3 +/- 8.2 mm; group 2: 16.8 +/- 5.7 mm; p < 0.0001 for each group compared to baseline) and LVOTG improved during FU (group 1: 25.5 +/- 20.0 mmHg; group 2: 22.1 +/- 21.7 mmHg; p < 0.0001 for each group). Intrahospital mortality was 0.0% in patients 14-25 years and 0.9% in the reference group. Persistent AV-block was observed in 12.2% of the group 1 and 15.9% of the group 2 patients (p = n.s.). CONCLUSION: ASA is safe and effective in HOCM patients 14-25 years of age in experienced centres. CI - (c) 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany. FAU - Lawin, Dennis AU - Lawin D AD - Department of Cardiology and Intensive Care Medicine, Klinikum Bielefeld gemGmbH, University Hospital OWL, Teutoburger Strasse 50, 33604, Bielefeld, Germany. FAU - Lawrenz, Thorsten AU - Lawrenz T AD - Department of Cardiology and Intensive Care Medicine, Klinikum Bielefeld gemGmbH, University Hospital OWL, Teutoburger Strasse 50, 33604, Bielefeld, Germany. AD - Faculty of Health, University Witten/Herdecke, Alfred Herrenhausen Strasse 50, 58455, Witten, Germany. FAU - Radke, Kristin AU - Radke K AD - Department of Cardiology and Intensive Care Medicine, Klinikum Bielefeld gemGmbH, University Hospital OWL, Teutoburger Strasse 50, 33604, Bielefeld, Germany. FAU - Stellbrink, Christoph AU - Stellbrink C AUID- ORCID: 0000-0002-8429-2826 AD - Department of Cardiology and Intensive Care Medicine, Klinikum Bielefeld gemGmbH, University Hospital OWL, Teutoburger Strasse 50, 33604, Bielefeld, Germany. christoph.stellbrink@klinikumbielefeld.de. LA - eng PT - Evaluation Study PT - Journal Article DEP - 20211124 PL - Germany TA - Clin Res Cardiol JT - Clinical research in cardiology : official journal of the German Cardiac Society JID - 101264123 RN - 3K9958V90M (Ethanol) SB - IM MH - Ablation Techniques/*methods MH - Adolescent MH - Adult MH - Atrioventricular Block/etiology MH - Cardiomyopathy, Hypertrophic/complications/*surgery MH - Ethanol/administration & dosage MH - Female MH - Humans MH - Male MH - Retrospective Studies MH - Treatment Outcome MH - Ventricular Septum/*surgery MH - Young Adult OTO - NOTNLM OT - Adolescents OT - Alcohol septal ablation OT - Hypertrophic obstructive cardiomyopathy OT - Outcome OT - Young adults EDAT- 2021/11/25 06:00 MHDA- 2022/02/22 06:00 CRDT- 2021/11/24 12:24 PHST- 2021/07/29 00:00 [received] PHST- 2021/10/21 00:00 [accepted] PHST- 2021/11/25 06:00 [pubmed] PHST- 2022/02/22 06:00 [medline] PHST- 2021/11/24 12:24 [entrez] AID - 10.1007/s00392-021-01960-6 [pii] AID - 10.1007/s00392-021-01960-6 [doi] PST - ppublish SO - Clin Res Cardiol. 2022 Feb;111(2):207-217. doi: 10.1007/s00392-021-01960-6. Epub 2021 Nov 24.