PMID- 34820412
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211126
IS  - 2296-861X (Print)
IS  - 2296-861X (Electronic)
IS  - 2296-861X (Linking)
VI  - 8
DP  - 2021
TI  - The Effects of L-Carnitine, Acetyl-L-Carnitine, and Propionyl-L-Carnitine on Body 
      Mass in Type 2 Diabetes Mellitus Patients.
PG  - 748075
LID - 10.3389/fnut.2021.748075 [doi]
LID - 748075
AB  - Purpose: The study aimed to explore the effects of l-carnitine, 
      acetyl-l-carnitine, and propionyl-l-carnitine on Body Mass in type 2 diabetes 
      mellitus (T2DM) patients. Methods: Randomized controlled trial (RCT) studies of 
      l-carnitine, acetyl-l-carnitine, and propionyl-l-carnitine in T2DM patients were 
      searched. The change rates of Body Mass index (BMI) from baseline values were 
      used as an evaluation indicator. The maximal effect (E(max)) model by non-linear 
      mixed-effect modeling (NONMEM) was used as the evaluation method. Results: A 
      total of 10 RCT studies, 1239 T2DM patients were included for analysis, including 
      eight studies of l-carnitine, one study of acetyl-l-carnitine, and one study of 
      propionyl-l-carnitine. The study found that l-carnitine could reduce the Body 
      Mass of T2DM patients. Based on only one study each for acetyl-l-carnitine and 
      propionyl-l-carnitine, no significant effects were found in acetyl-l-carnitine or 
      propionyl-l-carnitine. In addition, in order to achieve a plateau of efficacy 
      (80% E(max)), 2 g/day l-carnitine was required for at least 2 weeks. Conclusions: 
      Two g/day l-carnitine was required for at least 2 weeks to affect Body Mass in 
      T2DM patients, and no significant effects were found in acetyl-l-carnitine or 
      propionyl-l-carnitine.
CI  - Copyright (c) 2021 Wang, Wang, Yang, He and Wang.
FAU - Wang, Dong-Dong
AU  - Wang DD
AD  - Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy & School of 
      Pharmacy, Xuzhou Medical University, Xuzhou, China.
FAU - Wang, Tian-Yun
AU  - Wang TY
AD  - Department of Pharmacy, Huaian Hospital of Huaian City, Huaian, China.
FAU - Yang, Yang
AU  - Yang Y
AD  - Department of Pharmacy, The Affiliated Changzhou Children's Hospital of Nantong 
      University, Changzhou, China.
FAU - He, Su-Mei
AU  - He SM
AD  - Department of Pharmacy, The Affiliated Suzhou Science & Technology Town Hospital 
      of Nanjing Medical University, Suzhou, China.
FAU - Wang, You-Mei
AU  - Wang YM
AD  - Department of Pharmacy, Huaian Hospital of Huaian City, Huaian, China.
LA  - eng
PT  - Systematic Review
DEP - 20211108
PL  - Switzerland
TA  - Front Nutr
JT  - Frontiers in nutrition
JID - 101642264
PMC - PMC8606643
OTO - NOTNLM
OT  - Body Mass
OT  - acetyl-l-carnitine
OT  - l-carnitine
OT  - propionyl-l-carnitine
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/11/26 06:00
MHDA- 2021/11/26 06:01
PMCR- 2021/01/01
CRDT- 2021/11/25 06:39
PHST- 2021/08/07 00:00 [received]
PHST- 2021/10/11 00:00 [accepted]
PHST- 2021/11/25 06:39 [entrez]
PHST- 2021/11/26 06:00 [pubmed]
PHST- 2021/11/26 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fnut.2021.748075 [doi]
PST - epublish
SO  - Front Nutr. 2021 Nov 8;8:748075. doi: 10.3389/fnut.2021.748075. eCollection 2021.