PMID- 34822590 OWN - NLM STAT- MEDLINE DCOM- 20220222 LR - 20220222 IS - 2072-6651 (Electronic) IS - 2072-6651 (Linking) VI - 13 IP - 11 DP - 2021 Nov 15 TI - Associations between Serum Aflatoxin-B1 and Anemia in Pregnant Women: Evidence from Guangxi Zhuang Birth Cohort in China. LID - 10.3390/toxins13110806 [doi] LID - 806 AB - Aflatoxin B1 (AFB1) is a common toxic mycotoxin and is detectable in pregnant women. Animal studies have revealed that AFB1 caused the lysis of erythrocytes and a decrease in hemoglobin. We conducted a prospective cohort study in Guangxi, China, in order to evaluate the association between AFB1 exposure and anemia in pregnant women during the entire pregnancy. A total of 616 pregnant women from the Guangxi Zhuang Birth Cohort were included in the study. Serum AFB1-albumin (AFB1-ALB) adduct levels were measured. The effect of AFB1-ALB adducts on hemoglobin (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) were analyzed by using multivariable linear regression. The risks of anemia from AFB1-ALB adduct exposure were assessed by multivariable logistic regression. We found that the AFB1-ALB adduct was significantly associated with a decrease in Hb (beta = -4.99, 95% CI: -8.42, -1.30), MCV (beta = -4.58, 95% CI: -7.23, -1.94), MCH (beta = -1.86, 95% CI: -2.87, -0.85), and MCHC (beta = -5.23, 95% CI: -8.28, -2.17) in the first trimester with the third tertile of AFB1-ALB adducts when compared with the first tertile. Furthermore, the third tertile of the AFB1-ALB adduct significantly increased the risk of anemia by 2.90 times than compared to the first tertile in the first trimester (OR = 3.90, 95% CI: 1.67, 9.14). A significant positive does-response relationship existed between AFB1-ALB adduct levels and anemia risk (P(trend) = 0.001). When dividing anemia types, we only found that the third tertile of AFB1-ALB adduct increased the risk of microcytic hypochromic anemia (MHA) in the first trimester (OR = 14.37, 95% CI: 3.08, 67.02) and second trimester (OR = 4.75, 95% CI: 1.96, 11.51). These findings demonstrate the correlation between maternal AFB1 exposure during early pregnancy and risk of anemia, especially MHA, and during different trimesters in Southern China. More efforts should be made to diminish AFB1 exposure for pregnant women. FAU - Lei, Lei AU - Lei L AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning 530021, China. FAU - Liu, Shun AU - Liu S AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Guangxi Medical University, Nanning 530021, China. FAU - Ye, Ye AU - Ye Y AD - Center for Disease Control and Prevention, Guangxi Liuzhou Iron & Steel Group Co., Ltd., Liuzhou 545002, China. FAU - Qiu, Xiaoqiang AU - Qiu X AUID- ORCID: 0000-0001-9881-3664 AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning 530021, China. FAU - Huang, Dongping AU - Huang D AD - Department of Sanitary Chemistry, School of Public Health, Guangxi Medical University, Nanning 530021, China. FAU - Pan, Dongxiang AU - Pan D AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning 530021, China. FAU - Chen, Jiehua AU - Chen J AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning 530021, China. FAU - Qian, Zhengmin AU - Qian Z AD - Department of Epidemiology and Biostatistics, College for Public Health & Social Justice, Saint Louis University, St. Louis, MO 63103, USA. FAU - McMillin, Stephen Edward AU - McMillin SE AD - School of Social Work, College for Public Health & Social Justice, Saint Louis University, St. Louis, MO 63103, USA. FAU - Vaughn, Michael G AU - Vaughn MG AD - School of Social Work, College for Public Health & Social Justice, Saint Louis University, St. Louis, MO 63103, USA. FAU - Luo, Xingxi AU - Luo X AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning 530021, China. FAU - Wu, Kaili AU - Wu K AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning 530021, China. FAU - Xiao, Suyang AU - Xiao S AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning 530021, China. FAU - Li, Jinxiu AU - Li J AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning 530021, China. FAU - Liu, Meiliang AU - Liu M AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning 530021, China. FAU - Yang, Yu AU - Yang Y AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning 530021, China. FAU - Lai, Mingshuang AU - Lai M AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning 530021, China. FAU - Dong, Guanghui AU - Dong G AUID- ORCID: 0000-0002-2578-3369 AD - Department of Environmental and Occupational Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. FAU - Zeng, Xiaoyun AU - Zeng X AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning 530021, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20211115 PL - Switzerland TA - Toxins (Basel) JT - Toxins JID - 101530765 RN - 0 (Hemoglobins) RN - 9N2N2Y55MH (Aflatoxin B1) SB - IM MH - Adult MH - Aflatoxin B1/*blood MH - Anemia/*epidemiology/etiology MH - Anemia, Hypochromic/*epidemiology/etiology MH - China MH - Cohort Studies MH - Erythrocyte Indices/physiology MH - Female MH - Hemoglobins/metabolism MH - Humans MH - Infant, Newborn MH - Male MH - Maternal Exposure/adverse effects MH - Pregnancy MH - Pregnancy Complications, Hematologic/*epidemiology/etiology MH - Pregnancy Trimesters MH - Prospective Studies MH - Young Adult PMC - PMC8618761 OTO - NOTNLM OT - aflatoxin B1 OT - anemia OT - cohort study OT - erythrocyte parameters OT - hemoglobin OT - pregnant women COIS- The authors declare no conflict of interest. EDAT- 2021/11/26 06:00 MHDA- 2022/02/23 06:00 PMCR- 2021/11/15 CRDT- 2021/11/25 17:10 PHST- 2021/10/09 00:00 [received] PHST- 2021/11/08 00:00 [revised] PHST- 2021/11/10 00:00 [accepted] PHST- 2021/11/25 17:10 [entrez] PHST- 2021/11/26 06:00 [pubmed] PHST- 2022/02/23 06:00 [medline] PHST- 2021/11/15 00:00 [pmc-release] AID - toxins13110806 [pii] AID - toxins-13-00806 [pii] AID - 10.3390/toxins13110806 [doi] PST - epublish SO - Toxins (Basel). 2021 Nov 15;13(11):806. doi: 10.3390/toxins13110806.