PMID- 34822629 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20211128 IS - 2306-7381 (Electronic) IS - 2306-7381 (Linking) VI - 8 IP - 11 DP - 2021 Oct 29 TI - The Role of Pathology in the Diagnosis of Swine Respiratory Disease. LID - 10.3390/vetsci8110256 [doi] LID - 256 AB - The definition "porcine respiratory disease complex" (PRDC) is used to indicate the current approach for presenting respiratory pathology in modern pig farming. PRDC includes pneumonias with variable pictures, mixed with both aerogenous and hematogenous forms with variable etiology, often multimicrobial, and influenced by environmental and management factors. The notion that many etiological agents of swine respiratory pathology are ubiquitous in the airways is commonly understood; however, their isolation or identification is not always associable with the current pathology. In this complex context, lung lesions registered at slaughterhouse or during necropsy, and supplemented by histological investigations, must be considered as powerful tools for assigning a prominent role to etiologic agents. In recent years, the goal of colocalizing causative agents with the lesions they produce has been frequently applied, and valid examples in routine diagnostics are those that indicate pulmonary involvement during porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2) infections. FAU - Sarli, Giuseppe AU - Sarli G AUID- ORCID: 0000-0001-6405-3484 AD - Department of Veterinary Medical Sciences, University of Bologna, 40064 Bologna, BO, Italy. FAU - D'Annunzio, Giulia AU - D'Annunzio G AUID- ORCID: 0000-0003-0931-8421 AD - Department of Veterinary Medical Sciences, University of Bologna, 40064 Bologna, BO, Italy. FAU - Gobbo, Francesca AU - Gobbo F AD - Department of Veterinary Medical Sciences, University of Bologna, 40064 Bologna, BO, Italy. FAU - Benazzi, Cinzia AU - Benazzi C AUID- ORCID: 0000-0003-1726-0442 AD - Department of Veterinary Medical Sciences, University of Bologna, 40064 Bologna, BO, Italy. FAU - Ostanello, Fabio AU - Ostanello F AUID- ORCID: 0000-0003-1122-8628 AD - Department of Veterinary Medical Sciences, University of Bologna, 40064 Bologna, BO, Italy. LA - eng PT - Journal Article PT - Review DEP - 20211029 PL - Switzerland TA - Vet Sci JT - Veterinary sciences JID - 101680127 PMC - PMC8618091 OTO - NOTNLM OT - PRDC OT - diagnosis OT - histopathology OT - respiratory disease OT - swine COIS- The authors declare no conflict of interest. EDAT- 2021/11/26 06:00 MHDA- 2021/11/26 06:01 PMCR- 2021/10/29 CRDT- 2021/11/25 17:10 PHST- 2021/09/14 00:00 [received] PHST- 2021/10/23 00:00 [revised] PHST- 2021/10/26 00:00 [accepted] PHST- 2021/11/25 17:10 [entrez] PHST- 2021/11/26 06:00 [pubmed] PHST- 2021/11/26 06:01 [medline] PHST- 2021/10/29 00:00 [pmc-release] AID - vetsci8110256 [pii] AID - vetsci-08-00256 [pii] AID - 10.3390/vetsci8110256 [doi] PST - epublish SO - Vet Sci. 2021 Oct 29;8(11):256. doi: 10.3390/vetsci8110256.