PMID- 34822702
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240404
IS  - 2305-6304 (Electronic)
IS  - 2305-6304 (Linking)
VI  - 9
IP  - 11
DP  - 2021 Nov 16
TI  - Prenatal Exposure to Chemical Mixtures and Inhibition among Adolescents.
LID - 10.3390/toxics9110311 [doi]
LID - 311
AB  - Inhibition, one of the building blocks of executive function, is the ability to 
      focus one's attention despite interference from external stimuli. It undergoes 
      substantial development during adolescence and may be susceptible to adverse 
      impacts of prenatal exposure to chemical mixtures, yet few studies have explored 
      this association. The New Bedford Cohort (NBC) is a birth cohort of residents 
      living near the New Bedford Harbor Superfund site in Massachusetts. Among 
      adolescents from the NBC, we investigated the association of biomarkers of 
      prenatal exposure to organochlorines (DDE, HCB, PCBs) and metals (Pb, Mn) with 
      inhibition, assessed with the Delis-Kaplan Executive Function System Design 
      Fluency (non-verbal task) and Color-Word Interference (verbal task) subtests. An 
      exploratory mixtures analysis using Bayesian kernel machine regression (BKMR) 
      informed a traditional multivariable regression approach. NBC adolescents are 
      diverse with 29% non-white and 31% in a low-income household at birth. Cord serum 
      organochlorine concentrations and cord blood metals concentrations were generally 
      similar to other birth cohorts. In BKMR models, we observed a suggestive adverse 
      association of the chemical mixture with Color-Word Interference but not Design 
      Fluency. In covariate-adjusted linear regression models including all five 
      chemical exposure measures, a doubling of cord blood Mn was associated with 
      poorer Color-Word Interference completion time scaled scores (difference = -0.74; 
      95% CI: -1.34, -0.14). This study provided evidence of an adverse joint 
      association between prenatal exposure to a five-chemical mixture and verbal 
      inhibition in adolescence with exposure to Mn potentially driving this overall 
      association.
FAU - Oppenheimer, Anna V
AU  - Oppenheimer AV
AUID- ORCID: 0000-0002-9180-7007
AD  - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 
      Boston, MA 02115, USA.
FAU - Bellinger, David C
AU  - Bellinger DC
AD  - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 
      Boston, MA 02115, USA.
AD  - Department of Psychiatry, Boston Children's Hospital, Boston, MA 02115, USA.
FAU - Coull, Brent A
AU  - Coull BA
AD  - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 
      Boston, MA 02115, USA.
AD  - Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, 
      MA 02115, USA.
FAU - Weisskopf, Marc G
AU  - Weisskopf MG
AD  - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 
      Boston, MA 02115, USA.
AD  - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 
      02115, USA.
FAU - Zemplenyi, Michele
AU  - Zemplenyi M
AD  - Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, 
      MA 02115, USA.
FAU - Korrick, Susan A
AU  - Korrick SA
AUID- ORCID: 0000-0002-5966-1036
AD  - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 
      Boston, MA 02115, USA.
AD  - Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard 
      Medical School, Boston, MA 02115, USA.
LA  - eng
GR  - P30 ES000002/ES/NIEHS NIH HHS/United States
GR  - T42OH008416/ACL/ACL HHS/United States
PT  - Journal Article
DEP - 20211116
PL  - Switzerland
TA  - Toxics
JT  - Toxics
JID - 101639637
PMC - PMC8619850
OTO - NOTNLM
OT  - adolescent neurodevelopment
OT  - chemical mixtures
OT  - executive function
OT  - inhibition
OT  - metals
OT  - organochlorines
OT  - prenatal exposures
COIS- The authors declare no conflict of interest.
EDAT- 2021/11/26 06:00
MHDA- 2021/11/26 06:01
PMCR- 2021/11/16
CRDT- 2021/11/25 17:10
PHST- 2021/10/11 00:00 [received]
PHST- 2021/11/05 00:00 [revised]
PHST- 2021/11/10 00:00 [accepted]
PHST- 2021/11/25 17:10 [entrez]
PHST- 2021/11/26 06:00 [pubmed]
PHST- 2021/11/26 06:01 [medline]
PHST- 2021/11/16 00:00 [pmc-release]
AID - toxics9110311 [pii]
AID - toxics-09-00311 [pii]
AID - 10.3390/toxics9110311 [doi]
PST - epublish
SO  - Toxics. 2021 Nov 16;9(11):311. doi: 10.3390/toxics9110311.