PMID- 34823032
OWN - NLM
STAT- MEDLINE
DCOM- 20220308
LR  - 20220308
IS  - 1873-1597 (Electronic)
IS  - 1572-1000 (Linking)
VI  - 37
DP  - 2022 Mar
TI  - Photodynamic therapy in the treatment of oral lesions caused by 
      paracoccidiomycosis.
PG  - 102648
LID - S1572-1000(21)00466-X [pii]
LID - 10.1016/j.pdpdt.2021.102648 [doi]
AB  - Paracoccidioidomycosis (PCM) is an endemic disease caused by the dimorphic fungus 
      Paracocdioides brasiliensis and Paracoccidioides lutzii. Oral ulcers are usually 
      the first clinical signs of the disease. As it is a systemic fungal disease, 
      local treatments are considered complementary, such as photodynamic therapy 
      (aPDT). We present a patient with ulcerated lesions in the oral cavity of about 6 
      months duration. The pain complaint in the oropharynx led to a reduction in food 
      acceptance and a weight loss of around 40 kg. He underwent biopsy of the lip 
      lesion, and the histopathological report described yeast with multiple buds 
      compatible with PMC. Our team opted for treatment with aPDT sessions. Two 
      sessions were carried out in the ward and six in the ICU, showing satisfactory 
      results in the remission of ulcerated lesions associated with PCM as well as the 
      painful symptoms in the oral cavity. Also, the patient underwent Amphotericin B 
      and Sulfamethoxazole-trimethoprim. We believe that the association of aPDT with 
      pharmacological therapy possibly accelerated the repair process of oral lesions, 
      as well as providing fungal lesion decontamination, improving progressively the 
      healing of oral lesions.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Santos, Danila Silvana de Alexandria
AU  - Santos DSA
AD  - Department of Dentistry, Central Institute, Clinical Hospital of Medical School 
      of the University of Sao Paulo, Sao Paulo, SP, Brazil.
FAU - Galvao, Gustavo Souza
AU  - Galvao GS
AD  - Department of Dentistry, Central Institute, Clinical Hospital of Medical School 
      of the University of Sao Paulo, Sao Paulo, SP, Brazil.
FAU - Ribas, Priscila Fernandes
AU  - Ribas PF
AD  - Department of Dentistry, Central Institute, Clinical Hospital of Medical School 
      of the University of Sao Paulo, Sao Paulo, SP, Brazil. Electronic address: 
      priscila.ribas@hc.fm.usp.br.
FAU - Peres, Maria Paula Siqueira de Melo
AU  - Peres MPSM
AD  - Department of Dentistry, Central Institute, Clinical Hospital of Medical School 
      of the University of Sao Paulo, Sao Paulo, SP, Brazil. Electronic address: 
      maria.peres@hc.fm.usp.br.
FAU - Franco, Juliana Bertoldi
AU  - Franco JB
AD  - Department of Dentistry, Central Institute, Clinical Hospital of Medical School 
      of the University of Sao Paulo, Sao Paulo, SP, Brazil; Department of Dentistry, 
      Auxiliary Hospital of Suzano - Clinical Hospital of Medical School of the 
      University of Sao Paulo - Sao Paulo, SP, Brazil. Electronic address: 
      juliana.franco@hc.fm.usp.br.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20211122
PL  - Netherlands
TA  - Photodiagnosis Photodyn Ther
JT  - Photodiagnosis and photodynamic therapy
JID - 101226123
SB  - IM
MH  - Humans
MH  - Male
MH  - *Oral Ulcer/drug therapy
MH  - *Paracoccidioidomycosis/drug therapy
MH  - *Photochemotherapy/methods
OTO - NOTNLM
OT  - Dental Care
OT  - Oral Medicine
OT  - Oral and Maxillofacial Pathology
OT  - Paracoccidioidomycosis
OT  - Photodynamic Therapy
EDAT- 2021/11/26 06:00
MHDA- 2022/03/09 06:00
CRDT- 2021/11/25 20:13
PHST- 2021/07/16 00:00 [received]
PHST- 2021/11/18 00:00 [revised]
PHST- 2021/11/19 00:00 [accepted]
PHST- 2021/11/26 06:00 [pubmed]
PHST- 2022/03/09 06:00 [medline]
PHST- 2021/11/25 20:13 [entrez]
AID - S1572-1000(21)00466-X [pii]
AID - 10.1016/j.pdpdt.2021.102648 [doi]
PST - ppublish
SO  - Photodiagnosis Photodyn Ther. 2022 Mar;37:102648. doi: 
      10.1016/j.pdpdt.2021.102648. Epub 2021 Nov 22.