PMID- 34823427
OWN - NLM
STAT- MEDLINE
DCOM- 20220216
LR  - 20220429
IS  - 1651-2251 (Electronic)
IS  - 0001-6489 (Linking)
VI  - 141
IP  - 12
DP  - 2021 Dec
TI  - Decrement of prognostic nutrition index in laryngeal diseases: from precancerous 
      lesion to squamous cell carcinoma.
PG  - 1070-1074
LID - 10.1080/00016489.2019.1634836 [doi]
AB  - BACKGROUND: Malnutrition and systemic inflammatory response have been confirmed 
      to be important risk factors for various cancers. OBJECTIVE: To compare 
      pretreatment prognostic nutrition index (PNI) among patients with laryngeal 
      squamous cell carcinoma (LSCC), laryngeal precancerous lesion (LPL) and laryngeal 
      benign lesion (LBL). METHODS: A total of 253 male patients with laryngeal lesions 
      were divided into LBL, LPL with low risk (LPL (l)), LPL with high risk (LPL(h)), 
      LSCC (i), LSCC (ii) and LSCC (iii) groups according to their histopathological 
      findings and the TNM staging system. PNI and other clinical parameters were 
      calculated. Kruskal-Wallis, Mann-Whitney U or Chi-square or Fisher's exact test 
      were used for comparison of different parameters among groups. Logistic 
      regression was performed to estimate the odds ratios (OR) and the corresponding 
      95% confidence intervals (CI). RESULTS: The PNI in the LSCC group was 
      significantly lower than those of the LBL and LPL groups (p = .013 and p = .004, 
      respectively), and decreased from LPL(l) to LSCC (iii) (from 53.97 +/- 3.69 to 
      50.02 +/- 4.75). LPL patients with lower PNI values had a higher risk of LSCC, the 
      OR was 0.91 (95% CI: 0.84, 0.97) for a one-unit decrease. CONCLUSIONS: PNI could 
      be a simple and reproducible marker for predicting the severity of laryngeal 
      diseases.
FAU - Daquan, Wu
AU  - Daquan W
AUID- ORCID: 0000-0002-2006-9684
AD  - Department of Otolaryngology-Head and Neck Surgery, Zhongshan Hospital, Fudan 
      University, Shanghai, China.
FAU - Tian, Wang
AU  - Tian W
AUID- ORCID: 0000-0002-4323-2878
AD  - Department of Oncology, The Eighth People's Hospital of Shanghai, Shanghai, 
      China.
FAU - Shen, Na
AU  - Shen N
AD  - Department of Otolaryngology-Head and Neck Surgery, Zhongshan Hospital, Fudan 
      University, Shanghai, China.
FAU - Danzheng, Liu
AU  - Danzheng L
AD  - Department of Otolaryngology-Head and Neck Surgery, Zhongshan Hospital, Fudan 
      University, Shanghai, China.
FAU - Xinsheng, Huang
AU  - Xinsheng H
AUID- ORCID: 0000-0002-3781-8960
AD  - Department of Otolaryngology-Head and Neck Surgery, Zhongshan Hospital, Fudan 
      University, Shanghai, China.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20211126
PL  - England
TA  - Acta Otolaryngol
JT  - Acta oto-laryngologica
JID - 0370354
SB  - IM
MH  - Carcinoma, Squamous Cell/*pathology
MH  - Chi-Square Distribution
MH  - Humans
MH  - Laryngeal Diseases/*pathology
MH  - Laryngeal Neoplasms/*pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - *Nutrition Assessment
MH  - Patient Acuity
MH  - Precancerous Conditions/*pathology
MH  - Prognosis
MH  - Retrospective Studies
MH  - Squamous Cell Carcinoma of Head and Neck/pathology
MH  - Statistics, Nonparametric
OTO - NOTNLM
OT  - Prognostic nutrition index
OT  - laryngeal precancerous lesion
OT  - laryngeal squamous cell carcinoma
EDAT- 2021/11/27 06:00
MHDA- 2022/02/17 06:00
CRDT- 2021/11/26 05:30
PHST- 2021/11/27 06:00 [pubmed]
PHST- 2022/02/17 06:00 [medline]
PHST- 2021/11/26 05:30 [entrez]
AID - 10.1080/00016489.2019.1634836 [doi]
PST - ppublish
SO  - Acta Otolaryngol. 2021 Dec;141(12):1070-1074. doi: 10.1080/00016489.2019.1634836. 
      Epub 2021 Nov 26.