PMID- 34824345
OWN - NLM
STAT- MEDLINE
DCOM- 20220203
LR  - 20220203
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Nov 25
TI  - The outcomes of acute myocardial infarction patients comorbidity with 
      hypertension and hyperhomocysteinemia.
PG  - 22936
LID - 10.1038/s41598-021-02340-w [doi]
LID - 22936
AB  - This study investigated the outcomes and major adverse cardiovascular events 
      (MACEs) incurred by acute myocardial infarction (AMI) patients comorbiding with 
      hypertension and hyperhomocysteinemia (HHcy) during hospitalization and 1-year 
      follow-up. 648 consecutive AMI patients were divided into four categories: (1) 
      hypertension with Hcy >/= 15 micromol/L; (2) hypertension with Hcy < 15 micromol/L; (3) 
      no-hypertension with Hcy >/= 15 micromol/L; (4) no-hypertension with Hcy < 15 micromol/L. 
      Information taken from these case files included gender, past medical history, 
      vital signs, laboratory examination, electrocardiogram, coronary angiography, 
      cardiac ultrasound, and medicine treatment. The primary endpoints were duration 
      of coronary care units (CCU) stay, duration of in-hospital stay, and MACEs during 
      follow-up. Our data show that hypertension and HHcy have a synergistic effect in 
      AMI patients, AMI comorbiding with hypertension and HHcy patients had more severe 
      multi-coronary artery disease and more frequent non-culprit coronary lesions 
      complete clogging, had a higher prevalence of pro-brain natriuretic peptide, and 
      significant decreases in the left ventricular ejection fraction. These patients 
      had significant increases in the duration of CCU stay and in-hospital stay, had 
      significant increase in the rate of MACEs, had significant decreases in the 
      survival rate during follow-up.
CI  - (c) 2021. The Author(s).
FAU - Yan, Jumei
AU  - Yan J
AD  - Department of Cardiology, The First Affiliated Hospital of Nanchang University, 
      17 Yongwaizheng St, Nanchang, 330006, Jiangxi, China.
FAU - Zhou, Jiamin
AU  - Zhou J
AD  - Department of Cardiology, The First Affiliated Hospital of Nanchang University, 
      17 Yongwaizheng St, Nanchang, 330006, Jiangxi, China.
FAU - Huang, Jun
AU  - Huang J
AD  - Department of Cardiology, The First Affiliated Hospital of Nanchang University, 
      17 Yongwaizheng St, Nanchang, 330006, Jiangxi, China. junhuang918@163.com.
FAU - Zhang, Hongyu
AU  - Zhang H
AD  - Department of Cardiology, The First Affiliated Hospital of Nanchang University, 
      17 Yongwaizheng St, Nanchang, 330006, Jiangxi, China.
FAU - Deng, Zilin
AU  - Deng Z
AD  - Department of Cardiology, The First Affiliated Hospital of Nanchang University, 
      17 Yongwaizheng St, Nanchang, 330006, Jiangxi, China.
FAU - Du, Yun
AU  - Du Y
AD  - Department of Cardiology, The First Affiliated Hospital of Nanchang University, 
      17 Yongwaizheng St, Nanchang, 330006, Jiangxi, China.
LA  - eng
PT  - Journal Article
DEP - 20211125
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Aged
MH  - China/epidemiology
MH  - Comorbidity
MH  - Coronary Care Units
MH  - Female
MH  - Humans
MH  - Hyperhomocysteinemia/diagnosis/*epidemiology/mortality
MH  - Hypertension/diagnostic imaging/*epidemiology/mortality
MH  - Length of Stay
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/diagnosis/mortality/*therapy
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Time Factors
MH  - Treatment Outcome
PMC - PMC8617252
COIS- The authors declare no competing interests.
EDAT- 2021/11/27 06:00
MHDA- 2022/02/04 06:00
PMCR- 2021/11/25
CRDT- 2021/11/26 06:40
PHST- 2021/05/27 00:00 [received]
PHST- 2021/11/09 00:00 [accepted]
PHST- 2021/11/26 06:40 [entrez]
PHST- 2021/11/27 06:00 [pubmed]
PHST- 2022/02/04 06:00 [medline]
PHST- 2021/11/25 00:00 [pmc-release]
AID - 10.1038/s41598-021-02340-w [pii]
AID - 2340 [pii]
AID - 10.1038/s41598-021-02340-w [doi]
PST - epublish
SO  - Sci Rep. 2021 Nov 25;11(1):22936. doi: 10.1038/s41598-021-02340-w.