PMID- 34824844
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211127
IS  - 2049-9469 (Electronic)
IS  - 2049-9450 (Print)
IS  - 2049-9450 (Linking)
VI  - 16
IP  - 1
DP  - 2022 Jan
TI  - Clinical significance of oxidative stress for untreated patients with diffuse 
      large B-cell lymphoma.
PG  - 4
LID - 10.3892/mco.2021.2437 [doi]
LID - 4
AB  - Oxidative stress serves an important role in carcinogenesis. The present study 
      investigated the clinical significance of oxidative stress as a prognostic factor 
      for diffuse large B-cell lymphoma (DLBCL). The participants comprised 55 
      consecutive patients with DLBCL. A commercially available derivatives of reactive 
      oxygen metabolites (d-ROMs) test kit was used to assess oxidant levels. 
      Similarly, a commercially available biological antioxidant potential (BAP) test 
      was used to assess antioxidant levels. The antioxidative/oxidative stress ratio 
      was calculated as d-ROMs/BAP. The median serum concentration of d-ROMs was 425 
      microM. The levels of d-ROMs were significantly higher in patients with DLBCL than in 
      healthy volunteers (P<0.01). The complete remission (CR) rates in patients with 
      d-ROMs <425 and >/=425 microM were 81.5 and 85.7%, respectively [not significant (NS)]. 
      The 3-year overall survival (OS) rates for patients with d-ROMs <425 and >/=425 microM 
      were 67.2 and 72.0%, respectively (NS). The median BAP was 2,002 microM. The CR rates 
      of patients with BAP <2,002 and >/=2,002 microM were 77.8 and 88.9%, respectively (NS). 
      The 3-year OS rates of patients with BAP <2,002 and >/=2,002 microM were 60.9 and 
      75.9%, respectively (NS). No significant difference in the d-ROMs/BAP ratio was 
      observed between groups. Multivariate analysis revealed that d-ROMs were an 
      independent prognostic factor for progression-free survival.
CI  - Copyright (c) 2020, Spandidos Publications.
FAU - Nakamura, Hiroshi
AU  - Nakamura H
AD  - First Department of Internal Medicine, Gifu University Graduate School of 
      Medicine, Gifu 501-1194, Japan.
FAU - Hara, Takeshi
AU  - Hara T
AD  - First Department of Internal Medicine, Gifu University Graduate School of 
      Medicine, Gifu 501-1194, Japan.
AD  - Department of Hematology, Matsunami General Hospital, Kasamatsu-cho, Hashima-gun, 
      Gifu 501-6062, Japan.
FAU - Mabuchi, Ryoko
AU  - Mabuchi R
AD  - First Department of Internal Medicine, Gifu University Graduate School of 
      Medicine, Gifu 501-1194, Japan.
FAU - Matsumoto, Takuro
AU  - Matsumoto T
AD  - First Department of Internal Medicine, Gifu University Graduate School of 
      Medicine, Gifu 501-1194, Japan.
FAU - Nakamura, Nobuhiko
AU  - Nakamura N
AD  - First Department of Internal Medicine, Gifu University Graduate School of 
      Medicine, Gifu 501-1194, Japan.
FAU - Ninomiya, Soranobu
AU  - Ninomiya S
AD  - First Department of Internal Medicine, Gifu University Graduate School of 
      Medicine, Gifu 501-1194, Japan.
FAU - Kitagawa, Junichi
AU  - Kitagawa J
AD  - First Department of Internal Medicine, Gifu University Graduate School of 
      Medicine, Gifu 501-1194, Japan.
FAU - Kanemura, Nobuhiro
AU  - Kanemura N
AD  - First Department of Internal Medicine, Gifu University Graduate School of 
      Medicine, Gifu 501-1194, Japan.
FAU - Kito, Yusuke
AU  - Kito Y
AD  - Department of Pathology and Translational Research, Gifu University Graduate 
      School of Medicine, Gifu 501-1194, Japan.
FAU - Takami, Tsuyoshi
AU  - Takami T
AD  - Department of Pathology and Translational Research, Gifu University Graduate 
      School of Medicine, Gifu 501-1194, Japan.
FAU - Miyazaki, Tatsuhiko
AU  - Miyazaki T
AD  - Department of Pathology, Gifu University Hospital, Gifu 501-1194, Japan.
FAU - Takeuchi, Tamotsu
AU  - Takeuchi T
AD  - Department of Pathology and Translational Research, Gifu University Graduate 
      School of Medicine, Gifu 501-1194, Japan.
FAU - Shimizu, Masahito
AU  - Shimizu M
AD  - First Department of Internal Medicine, Gifu University Graduate School of 
      Medicine, Gifu 501-1194, Japan.
FAU - Tsurumi, Hisashi
AU  - Tsurumi H
AD  - First Department of Internal Medicine, Gifu University Graduate School of 
      Medicine, Gifu 501-1194, Japan.
AD  - Department of Hematology, Matsunami General Hospital, Kasamatsu-cho, Hashima-gun, 
      Gifu 501-6062, Japan.
LA  - eng
PT  - Journal Article
DEP - 20211104
PL  - England
TA  - Mol Clin Oncol
JT  - Molecular and clinical oncology
JID - 101613422
PMC - PMC8609529
OTO - NOTNLM
OT  - biological antioxidant potential test
OT  - derivatives of reactive oxygen metabolites test
OT  - diffuse large B-cell lymphoma
OT  - non-Hodgkin's lymphoma
OT  - oxidative stress
COIS- The authors declare that they have no competing interests.
EDAT- 2021/11/27 06:00
MHDA- 2021/11/27 06:01
PMCR- 2021/11/04
CRDT- 2021/11/26 06:54
PHST- 2020/05/15 00:00 [received]
PHST- 2021/07/14 00:00 [accepted]
PHST- 2021/11/26 06:54 [entrez]
PHST- 2021/11/27 06:00 [pubmed]
PHST- 2021/11/27 06:01 [medline]
PHST- 2021/11/04 00:00 [pmc-release]
AID - MCO-0-0-02437 [pii]
AID - 10.3892/mco.2021.2437 [doi]
PST - ppublish
SO  - Mol Clin Oncol. 2022 Jan;16(1):4. doi: 10.3892/mco.2021.2437. Epub 2021 Nov 4.