PMID- 34825277
OWN - NLM
STAT- MEDLINE
DCOM- 20220217
LR  - 20220217
IS  - 1435-2451 (Electronic)
IS  - 1435-2443 (Linking)
VI  - 407
IP  - 1
DP  - 2022 Feb
TI  - The characteristics of patients with macrovascular invasion in hepatocellular 
      carcinoma: when East meets West.
PG  - 225-234
LID - 10.1007/s00423-021-02370-y [doi]
AB  - PURPOSE: To evaluate the prevalence and extension of macrovascular invasion 
      (MaVI) in a large cohort of hepatocellular carcinoma (HCC) patients and analyze 
      the association between MaVI and overall survival (OS). METHODS: From 2011 to 
      2018, 2540 patients with newly diagnosed HCC who were managed in our institution 
      were enrolled in this retrospective study. Tumor invasion of the intrahepatic 
      branches of the portal or hepatic veins was defined as peripheral MaVI. Tumor 
      invasion of the main portal vein or inferior vena cava was defined as central 
      MaVI. RESULTS: MaVI prevalence was 16.2% (n = 411). Among patients with Barcelona 
      Clinic Liver Cancer (BCLC) stage C and Child-Pugh class A, 165 patients presented 
      with peripheral MaVI and 89 patients with central MaVI. The median OS was 
      13.2 months (95% confidence interval [CI]: 11.4-15.4) in the peripheral MaVI 
      group and 6.6 months (95% CI: 3.6-9.5) in the central MaVI group (p < 0.001). In 
      patients with BCLC stage C and Child-Pugh class B or BCLC stage D, 68 patients 
      presented with peripheral MaVI and 89 patients with central MaVI. The median OS 
      was 3.6 months (95% CI: 3.1-4.2) in the peripheral MaVI group and 2.8 months (95% 
      CI: 2.1-3.4) in the central MaVI group (p = 0.674). CONCLUSION: The extension of 
      MaVI significantly affected patient survival only in those with BCLC stage C and 
      Child-Pugh class A. In patients with BCLC stage C and Child-Pugh class B or BCLC 
      stage D, survival was poor irrespective of MaVI status.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Yen, Yi-Hao
AU  - Yen YH
AUID- ORCID: 0000-0001-6251-7230
AD  - Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung 
      Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 
      Ta Pei Road, Kaohsiung, Taiwan. cassellyen@yahoo.com.tw.
FAU - Li, Wei-Feng
AU  - Li WF
AD  - Liver Transplantation Center and Department of Surgery, Kaohsiung Chang Gung 
      Memorial Hospital, 123 Ta Pei Road, Kaohsiung, Taiwan.
FAU - Kee, Kwong-Ming
AU  - Kee KM
AD  - Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung 
      Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 
      Ta Pei Road, Kaohsiung, Taiwan.
FAU - Wang, Chih-Chi
AU  - Wang CC
AD  - Liver Transplantation Center and Department of Surgery, Kaohsiung Chang Gung 
      Memorial Hospital, 123 Ta Pei Road, Kaohsiung, Taiwan. ufel4996@ms26.hinet.net.
FAU - Cheng, Yu-Fan
AU  - Cheng YF
AD  - Liver Transplantation Center, Department of Diagnostic Radiology, Kaohsiung Chang 
      Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, 
      Taiwan.
FAU - Wang, Jing-Houng
AU  - Wang JH
AD  - Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung 
      Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 
      Ta Pei Road, Kaohsiung, Taiwan.
FAU - Lu, Sheng-Nan
AU  - Lu SN
AD  - Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung 
      Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 
      Ta Pei Road, Kaohsiung, Taiwan.
FAU - Hung, Chao-Hung
AU  - Hung CH
AD  - Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung 
      Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 
      Ta Pei Road, Kaohsiung, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20211125
PL  - Germany
TA  - Langenbecks Arch Surg
JT  - Langenbeck's archives of surgery
JID - 9808285
SB  - IM
MH  - *Carcinoma, Hepatocellular/pathology
MH  - Humans
MH  - *Liver Neoplasms/pathology
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Barcelona Clinic Liver Cancer
OT  - Hepatocellular carcinoma
OT  - Macrovascular invasion
EDAT- 2021/11/27 06:00
MHDA- 2022/02/19 06:00
CRDT- 2021/11/26 07:03
PHST- 2021/07/23 00:00 [received]
PHST- 2021/10/27 00:00 [accepted]
PHST- 2021/11/27 06:00 [pubmed]
PHST- 2022/02/19 06:00 [medline]
PHST- 2021/11/26 07:03 [entrez]
AID - 10.1007/s00423-021-02370-y [pii]
AID - 10.1007/s00423-021-02370-y [doi]
PST - ppublish
SO  - Langenbecks Arch Surg. 2022 Feb;407(1):225-234. doi: 10.1007/s00423-021-02370-y. 
      Epub 2021 Nov 25.