PMID- 34825586
OWN - NLM
STAT- MEDLINE
DCOM- 20220127
LR  - 20220127
IS  - 1752-8984 (Electronic)
IS  - 1479-1641 (Print)
IS  - 1479-1641 (Linking)
VI  - 18
IP  - 6
DP  - 2021 Nov-Dec
TI  - Peripheral oscillometric arterial performance does not depict coronary status in 
      patients with type 2 diabetes mellitus.
PG  - 14791641211046522
LID - 10.1177/14791641211046522 [doi]
LID - 14791641211046522
AB  - BACKGROUND: Arterial stiffness is associated with cardiovascular events. Matrix 
      metalloproteases (MMPs), their tissue inhibitors (TIMPs) and galectin-3 are 
      involved in the pathogenesis of end organ damage. This study aimed to evaluate 
      the contribution of arterial stiffness, MMPs, TIMPs and galectin-3 with the 
      current vascular status in type 2 diabetes mellitus (T2DM). METHODS: 74 patients 
      with T2DM, 36 with coronary heart disease (CHD) (T2DM + CHD) and 38 without CHD 
      (T2DM - CHD) were included. Aortic pulse wave velocity (PWVao), aortic and 
      brachial augmentation indices (AIx aortic and AIx brachial) and central-aortic 
      blood pressure values were determined by non-invasive arteriography. MMPs, TIMPs 
      and galectin-3 plasma concentrations were analysed by ELISA. RESULTS: Patients 
      with T2DM and CHD presented with significantly increased arterial stiffness 
      determined as AIx and significantly elevated values for TIMP-4 and galectin-3. 
      Heterogeneous peripheral vascular status regardless of the CHD status was 
      observed, and increasing severity of CHD was associated with an increased 
      arterial stiffness. TIMP-4 correlated significantly with an elevated PWVao in the 
      whole cohort independently from CHD status. CONCLUSION: Determination of arterial 
      stiffness is an effective and, compared to laboratory markers, more reliable 
      method for determining the peripheral vascular situation in patients with T2DM, 
      but it does not clearly depict coronary situation.
FAU - Jaeger, Magdalene
AU  - Jaeger M
AD  - Herz- und Diabeteszentrum NRW, 39059Ruhr Universitat Bochum, Bad Oeynhausen, 
      Germany.
FAU - Stratmann, Bernd
AU  - Stratmann B
AUID- ORCID: 0000-0001-5777-3715
AD  - Herz- und Diabeteszentrum NRW, 39059Ruhr Universitat Bochum, Bad Oeynhausen, 
      Germany.
FAU - Tschoepe, Diethelm
AU  - Tschoepe D
AD  - Herz- und Diabeteszentrum NRW, 39059Ruhr Universitat Bochum, Bad Oeynhausen, 
      Germany.
AD  - Stiftung DHD (Der herzkranke Diabetiker) Stiftung in der Deutschen 
      Diabetes-Stiftung, Bad Oeynhausen, Germany.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Diab Vasc Dis Res
JT  - Diabetes & vascular disease research
JID - 101234011
SB  - IM
MH  - Aorta/diagnostic imaging
MH  - Brachial Artery
MH  - *Diabetes Mellitus, Type 2/complications/diagnosis
MH  - Humans
MH  - Pulse Wave Analysis
MH  - *Vascular Stiffness
PMC - PMC8743959
OTO - NOTNLM
OT  - MMP
OT  - TIMP
OT  - Type 2 diabetes mellitus
OT  - arterial stiffness
OT  - coronary heart disease
OT  - galectin-3
COIS- Declaration of conflicting interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2021/11/27 06:00
MHDA- 2022/01/28 06:00
PMCR- 2021/11/26
CRDT- 2021/11/26 08:37
PHST- 2021/11/26 08:37 [entrez]
PHST- 2021/11/27 06:00 [pubmed]
PHST- 2022/01/28 06:00 [medline]
PHST- 2021/11/26 00:00 [pmc-release]
AID - 10.1177_14791641211046522 [pii]
AID - 10.1177/14791641211046522 [doi]
PST - ppublish
SO  - Diab Vasc Dis Res. 2021 Nov-Dec;18(6):14791641211046522. doi: 
      10.1177/14791641211046522.