PMID- 34827678
OWN - NLM
STAT- MEDLINE
DCOM- 20220112
LR  - 20220112
IS  - 2218-273X (Electronic)
IS  - 2218-273X (Linking)
VI  - 11
IP  - 11
DP  - 2021 Nov 12
TI  - Changes in Cardiac Metabolism in Prediabetes.
LID - 10.3390/biom11111680 [doi]
LID - 1680
AB  - In type 2 diabetes mellitus (T2DM), there is an increased prevalence of 
      cardiovascular disease (CVD), even when corrected for atherosclerosis and other 
      CVD risk factors. Diastolic dysfunction is one of the early changes in cardiac 
      function that precedes the onset of cardiac failure, and it occurs already in the 
      prediabetic state. It is clear that these changes are closely linked to 
      alterations in cardiac metabolism; however, the exact etiology is unknown. In 
      this narrative review, we provide an overview of the early cardiac changes in 
      fatty acid and glucose metabolism in prediabetes and its consequences on cardiac 
      function. A better understanding of the relationship between metabolism, 
      mitochondrial function, and cardiac function will lead to insights into the 
      etiology of the declined cardiac function in prediabetes.
FAU - de Wit-Verheggen, Vera H W
AU  - de Wit-Verheggen VHW
AUID- ORCID: 0000-0002-3711-5034
AD  - Department of Nutrition and Movement Sciences, School for Nutrition and 
      Translational Research in Metabolism, Maastricht University Medical Center, 6200 
      MD Maastricht, The Netherlands.
FAU - van de Weijer, Tineke
AU  - van de Weijer T
AD  - Department of Nutrition and Movement Sciences, School for Nutrition and 
      Translational Research in Metabolism, Maastricht University Medical Center, 6200 
      MD Maastricht, The Netherlands.
AD  - Department of Radiology and Nuclear Medicine, Maastricht University Medical 
      Center, 6200 MD Maastricht, The Netherlands.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20211112
PL  - Switzerland
TA  - Biomolecules
JT  - Biomolecules
JID - 101596414
SB  - IM
MH  - Cardiovascular Diseases
MH  - *Diabetes Mellitus, Type 2
MH  - Humans
MH  - *Prediabetic State
PMC - PMC8615987
OTO - NOTNLM
OT  - cardiac function
OT  - cardiac metabolism
OT  - mitochondrial function
OT  - prediabetes
COIS- The authors declare that they have no conflict of interest.
EDAT- 2021/11/28 06:00
MHDA- 2022/01/13 06:00
PMCR- 2021/11/12
CRDT- 2021/11/27 01:03
PHST- 2021/10/13 00:00 [received]
PHST- 2021/10/28 00:00 [revised]
PHST- 2021/11/08 00:00 [accepted]
PHST- 2021/11/27 01:03 [entrez]
PHST- 2021/11/28 06:00 [pubmed]
PHST- 2022/01/13 06:00 [medline]
PHST- 2021/11/12 00:00 [pmc-release]
AID - biom11111680 [pii]
AID - biomolecules-11-01680 [pii]
AID - 10.3390/biom11111680 [doi]
PST - epublish
SO  - Biomolecules. 2021 Nov 12;11(11):1680. doi: 10.3390/biom11111680.