PMID- 34831376
OWN - NLM
STAT- MEDLINE
DCOM- 20211217
LR  - 20240226
IS  - 2073-4409 (Electronic)
IS  - 2073-4409 (Linking)
VI  - 10
IP  - 11
DP  - 2021 Nov 13
TI  - Multi-Tissue Characterization of GILZ Expression in Dendritic Cell Subsets at 
      Steady State and in Inflammatory Contexts.
LID - 10.3390/cells10113153 [doi]
LID - 3153
AB  - Dendritic cells (DCs) are key players in the control of tolerance and immunity. 
      Glucocorticoids (GCs) are known to regulate DC function by promoting their 
      tolerogenic differentiation through the induction of inhibitory ligands, 
      cytokines, and enzymes. The GC-induced effects in DCs were shown to critically 
      depend on increased expression of the Glucocorticoid-Induced Leucine Zipper 
      protein (GILZ). GILZ expression levels were further shown to control 
      antigen-presenting cell function, as well as T-cell priming capacity of DCs. 
      However, the pattern of GILZ expression in DC subsets across tissues remains 
      poorly described, as well as the modulation of its expression levels in different 
      pathological settings. To fill in this knowledge gap, we conducted an exhaustive 
      analysis of GILZ relative expression levels in DC subsets from various tissues 
      using multiparametric flow cytometry. This study was performed at steady state, 
      in the context of acute as well as chronic skin inflammation, and in a model of 
      cancer. Our results show the heterogeneity of GILZ expression among DC subsets as 
      well as the complexity of its modulation, that varies in a cell subset- and 
      context-specific manner. Considering the contribution of GILZ in the control of 
      DC functions and its potential as an immune checkpoint in cancer settings, these 
      results are of high relevance for optimal GILZ targeting in therapeutic 
      strategies.
FAU - Docq, Molene
AU  - Docq M
AD  - Inserm U996, Inflammation, Microbiome and Immunosurveillance, Universite 
      Paris-Saclay, 92140 Clamart, France.
FAU - Vetillard, Mathias
AU  - Vetillard M
AUID- ORCID: 0000-0001-5503-4900
AD  - Inserm U996, Inflammation, Microbiome and Immunosurveillance, Universite 
      Paris-Saclay, 92140 Clamart, France.
FAU - Gallego, Carmen
AU  - Gallego C
AUID- ORCID: 0000-0003-0180-5671
AD  - Inserm U996, Inflammation, Microbiome and Immunosurveillance, Universite 
      Paris-Saclay, 92140 Clamart, France.
FAU - Jaracz-Ros, Agnieszka
AU  - Jaracz-Ros A
AD  - Inserm U996, Inflammation, Microbiome and Immunosurveillance, Universite 
      Paris-Saclay, 92140 Clamart, France.
FAU - Mercier-Nome, Francoise
AU  - Mercier-Nome F
AUID- ORCID: 0000-0002-9515-7232
AD  - Inserm U996, Inflammation, Microbiome and Immunosurveillance, Universite 
      Paris-Saclay, 92140 Clamart, France.
AD  - IPSIT SFR-UMS, CNRS, Inserm, Institut Paris Saclay d'Innovation Therapeutique, 
      Universite Paris-Saclay, 92296 Chatenay-Malabry, France.
FAU - Bachelerie, Francoise
AU  - Bachelerie F
AUID- ORCID: 0000-0002-0399-3277
AD  - Inserm U996, Inflammation, Microbiome and Immunosurveillance, Universite 
      Paris-Saclay, 92140 Clamart, France.
FAU - Schlecht-Louf, Geraldine
AU  - Schlecht-Louf G
AUID- ORCID: 0000-0002-7924-5371
AD  - Inserm U996, Inflammation, Microbiome and Immunosurveillance, Universite 
      Paris-Saclay, 92140 Clamart, France.
LA  - eng
GR  - 641833-ONCORNET/MSCA-ITN-2014-ETN/Marie Sklodowska-Curie Innovative Training 
      Networks (ITN-ETN)/
GR  - [ANR]-15-IFEC-0004-01/ERA-Net Infect-ERA "HPVMOTIVA", Agence Nationale de la 
      Recherche/
GR  - ANR-10-LABX-33/LabEx LERMIT (Laboratory of Excellence in Research on Medication 
      and Innovative Therapeu-tics)/
GR  - FDT201805005700/Fondation pour la Recherche Medicale/
GR  - PJA 20151203219/Fondation ARC pour la Recherche sur le Cancer/
GR  - IP/SC-15956/Ligue Nationale Contre le Cancer/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211113
PL  - Switzerland
TA  - Cells
JT  - Cells
JID - 101600052
RN  - 0 (Biomarkers)
RN  - 0 (Dsip1 protein, mouse)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Acute Disease
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Cell Line, Tumor
MH  - Cell Movement
MH  - Chronic Disease
MH  - Dendritic Cells/*pathology
MH  - Inflammation/*pathology
MH  - Langerhans Cells/pathology
MH  - Lymph Nodes/metabolism
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Neoplasms/pathology
MH  - *Organ Specificity
MH  - Skin/pathology
MH  - Transcription Factors/*metabolism
MH  - Mice
PMC - PMC8623566
OTO - NOTNLM
OT  - Tsc22d3/GILZ
OT  - cancer
OT  - dendritic cells
OT  - inflammation
OT  - skin
COIS- The authors declare no conflict of interest.
EDAT- 2021/11/28 06:00
MHDA- 2021/12/18 06:00
PMCR- 2021/11/13
CRDT- 2021/11/27 01:15
PHST- 2021/09/28 00:00 [received]
PHST- 2021/11/05 00:00 [revised]
PHST- 2021/11/11 00:00 [accepted]
PHST- 2021/11/27 01:15 [entrez]
PHST- 2021/11/28 06:00 [pubmed]
PHST- 2021/12/18 06:00 [medline]
PHST- 2021/11/13 00:00 [pmc-release]
AID - cells10113153 [pii]
AID - cells-10-03153 [pii]
AID - 10.3390/cells10113153 [doi]
PST - epublish
SO  - Cells. 2021 Nov 13;10(11):3153. doi: 10.3390/cells10113153.