PMID- 34832859
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240404
IS  - 1424-8247 (Print)
IS  - 1424-8247 (Electronic)
IS  - 1424-8247 (Linking)
VI  - 14
IP  - 11
DP  - 2021 Oct 25
TI  - A Comprehensive Review of HLA and Severe Cutaneous Adverse Drug Reactions: 
      Implication for Clinical Pharmacogenomics and Precision Medicine.
LID - 10.3390/ph14111077 [doi]
LID - 1077
AB  - Human leukocyte antigen (HLA) encoded by the HLA gene is an important modulator 
      for immune responses and drug hypersensitivity reactions as well. Genetic 
      polymorphisms of HLA vary widely at population level and are responsible for 
      developing severe cutaneous adverse drug reactions (SCARs) such as 
      Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug reaction 
      with eosinophilia and systemic symptoms (DRESS), maculopapular exanthema (MPE). 
      The associations of different HLA alleles with the risk of drug induced SJS/TEN, 
      DRESS and MPE are strongly supportive for clinical considerations. Prescribing 
      guidelines generated by different national and international working groups for 
      translation of HLA pharmacogenetics into clinical practice are underway and 
      functional in many countries, including Thailand. Cutting edge genomic 
      technologies may accelerate wider adoption of HLA screening in routine clinical 
      settings. There are great opportunities and several challenges as well for 
      effective implementation of HLA genotyping globally in routine clinical practice 
      for the prevention of drug induced SCARs substantially, enforcing precision 
      medicine initiatives.
FAU - Kloypan, Chiraphat
AU  - Kloypan C
AUID- ORCID: 0000-0003-0547-1381
AD  - Unit of Excellence in Integrative Molecular Biomedicine, School of Allied Health 
      Sciences, University of Phayao, Phayao 56000, Thailand.
AD  - Division of Clinical Immunology and Transfusion Science, Department of Medical 
      Technology, School of Allied Health Sciences, University of Phayao, Phayao 56000, 
      Thailand.
FAU - Koomdee, Napatrupron
AU  - Koomdee N
AD  - Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, 
      Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, 
      Thailand.
AD  - Laboratory for Pharmacogenomics, Ramathibodi Hospital, Somdech Phra Debaratana 
      Medical Center SDMC, Bangkok 10400, Thailand.
FAU - Satapornpong, Patompong
AU  - Satapornpong P
AD  - Division of General Pharmacy Practice, Department of Pharmaceutical Care, College 
      of Pharmacy, Rangsit University, Pathum Thani 12000, Thailand.
AD  - Excellence Pharmacogenomics and Precision Medicine Centre, College of Pharmacy, 
      Rangsit University, Pathum Thani 12000, Thailand.
FAU - Tempark, Therdpong
AU  - Tempark T
AD  - Division of Dermatology, Department of Pediatrics, Faculty of Medicine, 
      Chulalongkorn University, Bangkok 10330, Thailand.
FAU - Biswas, Mohitosh
AU  - Biswas M
AUID- ORCID: 0000-0003-1432-7701
AD  - Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, 
      Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, 
      Thailand.
AD  - Laboratory for Pharmacogenomics, Ramathibodi Hospital, Somdech Phra Debaratana 
      Medical Center SDMC, Bangkok 10400, Thailand.
AD  - Department of Pharmacy, University of Rajshahi, Rajshahi 6205, Bangladesh.
FAU - Sukasem, Chonlaphat
AU  - Sukasem C
AUID- ORCID: 0000-0003-0033-5321
AD  - Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, 
      Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, 
      Thailand.
AD  - Laboratory for Pharmacogenomics, Ramathibodi Hospital, Somdech Phra Debaratana 
      Medical Center SDMC, Bangkok 10400, Thailand.
AD  - The Thai Severe Cutaneous Adverse Drug Reaction THAI-SCAR Research-Genomics 
      Thailand, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
AD  - The Preventive Genomics & Family Check-Up Services Center, Bumrungrad 
      International Hospital, Pharmacogenomics and Precision Medicine Clinic, Bangkok 
      10110, Thailand.
AD  - MRC Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, 
      Institute of Systems, Molecular and Integrative Biology, University of Liverpool, 
      Liverpool L69 3GL, UK.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20211025
PL  - Switzerland
TA  - Pharmaceuticals (Basel)
JT  - Pharmaceuticals (Basel, Switzerland)
JID - 101238453
PMC - PMC8622011
OTO - NOTNLM
OT  - HLA genetic polymorphisms
OT  - SCARs
OT  - human leukocyte antigen
OT  - pharmacogenomics
OT  - precision medicine
COIS- The authors declare no conflict of interest.
EDAT- 2021/11/28 06:00
MHDA- 2021/11/28 06:01
PMCR- 2021/10/25
CRDT- 2021/11/27 01:20
PHST- 2021/09/09 00:00 [received]
PHST- 2021/10/13 00:00 [revised]
PHST- 2021/10/18 00:00 [accepted]
PHST- 2021/11/27 01:20 [entrez]
PHST- 2021/11/28 06:00 [pubmed]
PHST- 2021/11/28 06:01 [medline]
PHST- 2021/10/25 00:00 [pmc-release]
AID - ph14111077 [pii]
AID - pharmaceuticals-14-01077 [pii]
AID - 10.3390/ph14111077 [doi]
PST - epublish
SO  - Pharmaceuticals (Basel). 2021 Oct 25;14(11):1077. doi: 10.3390/ph14111077.