PMID- 34833321
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211130
IS  - 2073-4360 (Electronic)
IS  - 2073-4360 (Linking)
VI  - 13
IP  - 22
DP  - 2021 Nov 20
TI  - Electron-Beam-Induced Grafting of Chitosan onto HDPE/ATZ Composites for 
      Biomedical Applications.
LID - 10.3390/polym13224016 [doi]
LID - 4016
AB  - The surface functionalisation of high-density polyethylene (HDPE) and 
      HDPE/alumina-toughened zirconia (ATZ) surfaces with chitosan via electron-beam 
      (EB) irradiation technique was exploited for preparing materials suitable for 
      biomedical purposes. ATR-FTIR analysis and wettability measurements were employed 
      for monitoring the surface changes after both irradiation and chitosan grafting 
      reaction. Interestingly, the presence of ATZ loadings beyond 2 wt% influenced 
      both the EB irradiation process and the chitosan functionalisation reaction, 
      decreasing the oxidation of the surface and the chitosan grafting. The EB 
      irradiation induced an increase in Young's modulus and a decrease in the 
      elongation at the break of all analysed systems, whereas the tensile strength was 
      not affected in a relevant way. Biological assays indicated that electrostatic 
      interactions between the negative charges of the surface of cell membranes and 
      the -NH(3)(+) sites on chitosan chains promoted cell adhesion, while some 
      oxidised species produced during the irradiation process are thought to cause a 
      detrimental effect on the cell viability.
FAU - Faga, Maria Giulia
AU  - Faga MG
AD  - Istituto di Scienze e Tecnologie per l'Energia e la Mobilita Sostenibili 
      (STEMS)-UOS di Torino, Consiglio Nazionale delle Ricerche, Strada delle Cacce 73, 
      10135 Torino, Italy.
FAU - Duraccio, Donatella
AU  - Duraccio D
AD  - Istituto di Scienze e Tecnologie per l'Energia e la Mobilita Sostenibili 
      (STEMS)-UOS di Torino, Consiglio Nazionale delle Ricerche, Strada delle Cacce 73, 
      10135 Torino, Italy.
FAU - Di Maro, Mattia
AU  - Di Maro M
AUID- ORCID: 0000-0002-1553-3948
AD  - Istituto di Scienze e Tecnologie per l'Energia e la Mobilita Sostenibili 
      (STEMS)-UOS di Torino, Consiglio Nazionale delle Ricerche, Strada delle Cacce 73, 
      10135 Torino, Italy.
FAU - Kowandy, Christelle
AU  - Kowandy C
AUID- ORCID: 0000-0002-3276-0763
AD  - Institut de Chimie Moleculaire de Reims (ICMR), UMR CNRS 7312, Universite de 
      Reims Champagne-Ardenne, Moulin de la Housse, BP 1039, CEDEX 2, 51687 Reims, 
      France.
FAU - Malucelli, Giulio
AU  - Malucelli G
AUID- ORCID: 0000-0002-0459-7698
AD  - Politecnico di Torino-Dipartimento di Scienza Applicata e Tecnologia, and Local 
      INSTM Unit, Viale Teresa Michel 5, 15121 Alessandria, Italy.
FAU - Mussano, Federico Davide
AU  - Mussano FD
AUID- ORCID: 0000-0001-5800-0749
AD  - Dipartimento di Scienze Chirurgiche CIR Dental School, Universita di Torino, via 
      Nizza 230, 10126 Torino, Italy.
FAU - Genova, Tullio
AU  - Genova T
AUID- ORCID: 0000-0001-7824-8389
AD  - Dipartimento Scienze della Vita e Biologia dei Sistemi, Universita di Torino, via 
      Accademia Albertina 13, 10123 Torino, Italy.
FAU - Coqueret, Xavier
AU  - Coqueret X
AUID- ORCID: 0000-0002-9645-5506
AD  - Institut de Chimie Moleculaire de Reims (ICMR), UMR CNRS 7312, Universite de 
      Reims Champagne-Ardenne, Moulin de la Housse, BP 1039, CEDEX 2, 51687 Reims, 
      France.
LA  - eng
PT  - Journal Article
DEP - 20211120
PL  - Switzerland
TA  - Polymers (Basel)
JT  - Polymers
JID - 101545357
PMC - PMC8623127
OTO - NOTNLM
OT  - alumina-toughened zirconia (ATZ)
OT  - cell adhesion
OT  - chitosan
OT  - electron-beam irradiation
OT  - high-density polyethylene (HDPE)
OT  - mechanical properties
OT  - nano-roughness
OT  - radiation-induced grafting
OT  - viability
OT  - wettability
COIS- The authors declare no conflict of interest.
EDAT- 2021/11/28 06:00
MHDA- 2021/11/28 06:01
PMCR- 2021/11/20
CRDT- 2021/11/27 01:21
PHST- 2021/10/27 00:00 [received]
PHST- 2021/11/17 00:00 [revised]
PHST- 2021/11/18 00:00 [accepted]
PHST- 2021/11/27 01:21 [entrez]
PHST- 2021/11/28 06:00 [pubmed]
PHST- 2021/11/28 06:01 [medline]
PHST- 2021/11/20 00:00 [pmc-release]
AID - polym13224016 [pii]
AID - polymers-13-04016 [pii]
AID - 10.3390/polym13224016 [doi]
PST - epublish
SO  - Polymers (Basel). 2021 Nov 20;13(22):4016. doi: 10.3390/polym13224016.