PMID- 34834489
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211129
IS  - 2075-4426 (Print)
IS  - 2075-4426 (Electronic)
IS  - 2075-4426 (Linking)
VI  - 11
IP  - 11
DP  - 2021 Nov 2
TI  - Probable Factors Associated with Response to Mesenchymal Stem Cell Therapy in 
      Stroke Patients: A Post Hoc Analysis of the STARTING-2 Trial.
LID - 10.3390/jpm11111137 [doi]
LID - 1137
AB  - The aim of this study was to identify factors associated with improved motor 
      function of the lower extremities in response to mesenchymal stem cell (MSC) 
      therapy in patients with ischemic stroke. This study was a post hoc analysis of 
      data from a prospective, open-label, randomized controlled trial of MSC therapy 
      for patients with ischemic stroke patients associated with severe middle cerebral 
      artery territory (STARTING-2 trial). Lower limb motor function was scored based 
      on the lower limb of Fugl-Meyer assessment (FMA-LL) score before MSC therapy and 
      at 3 months after stroke. All FMA-LL changes greater than or equal to six points 
      were considered clinically significant. Univariate and multivariate binary 
      logistic regression models were used to determine possible predictors of 
      clinically significant lower limb motor response to MSC therapy. Twelve (33%) of 
      the thirty-six patients receiving MSC therapy reached a minimal clinically 
      important difference (MCID) of FMA-LL. The two independent factors with the 
      greatest impact on response to MSC therapy for achieving an MCID in FMA-LL score 
      were: (1) the time from stroke onset to MSC therapy, and (2) age (p < 0.05). In 
      addition, obese stroke patients responded better to MSC therapy than stroke 
      patients with normal weight. In conclusion, this post hoc analysis might suggest 
      the need for recruiting stroke patients at younger and early after stroke onset 
      in future clinical trials of MSC therapy for stroke.
FAU - Chang, Won Hyuk
AU  - Chang WH
AUID- ORCID: 0000-0002-4969-7895
AD  - Department of Physical and Rehabilitation Medicine, Center for Prevention and 
      Rehabilitation, Heart Vascular Stroke Institute, Samsung Medical Center, 
      Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
FAU - Lee, Jungsoo
AU  - Lee J
AUID- ORCID: 0000-0001-9439-0166
AD  - Department of Physical and Rehabilitation Medicine, Center for Prevention and 
      Rehabilitation, Heart Vascular Stroke Institute, Samsung Medical Center, 
      Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
FAU - Chung, Jong-Won
AU  - Chung JW
AD  - Departments of Neurology, Samsung Medical Center, Sungkyunkwan University School 
      of Medicine, Seoul 06351, Korea.
AD  - Translational and Stem Cell Research Laboratory on Stroke, Samsung Medical 
      Center, Seoul 06351, Korea.
FAU - Kim, Yun-Hee
AU  - Kim YH
AUID- ORCID: 0000-0001-6101-8851
AD  - Department of Physical and Rehabilitation Medicine, Center for Prevention and 
      Rehabilitation, Heart Vascular Stroke Institute, Samsung Medical Center, 
      Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
AD  - Department of Health Sciences and Technology, Department of Medical Device 
      Management & Research, Department of Digital Health, SAIHST, Sungkyunkwan 
      University, Seoul 06351, Korea.
FAU - Bang, Oh Young
AU  - Bang OY
AD  - Departments of Neurology, Samsung Medical Center, Sungkyunkwan University School 
      of Medicine, Seoul 06351, Korea.
AD  - Translational and Stem Cell Research Laboratory on Stroke, Samsung Medical 
      Center, Seoul 06351, Korea.
FAU - The Starting-Collaborators
AU  - The Starting-Collaborators
AD  - Departments of Neurology, Samsung Medical Center, Sungkyunkwan University School 
      of Medicine, Seoul 06351, Korea.
LA  - eng
GR  - HI14C16240000/the Korea Health Technology R&D Project, the Ministry of Health & 
      Welfare/
GR  - 1415174804/the Ministry of Trade, Industry & Energy (MOTIE, Korea)/
GR  - NRF-2020R1A2C3010304/a National Research Foundation of Korea (NRF) grant funded 
      by the Korean government/
GR  - NRF-2018R1D1A1A02086038/a National Research Foundation of Korea (NRF) grant 
      funded by the Korean government/
PT  - Journal Article
DEP - 20211102
PL  - Switzerland
TA  - J Pers Med
JT  - Journal of personalized medicine
JID - 101602269
PMC - PMC8621313
OTO - NOTNLM
OT  - mesenchymal stem cells
OT  - motor impairment
OT  - motor recovery
OT  - post hoc analysis
OT  - stroke
COIS- The authors declare no conflict of interest.
EDAT- 2021/11/28 06:00
MHDA- 2021/11/28 06:01
PMCR- 2021/11/02
CRDT- 2021/11/27 01:24
PHST- 2021/09/15 00:00 [received]
PHST- 2021/10/25 00:00 [revised]
PHST- 2021/10/29 00:00 [accepted]
PHST- 2021/11/27 01:24 [entrez]
PHST- 2021/11/28 06:00 [pubmed]
PHST- 2021/11/28 06:01 [medline]
PHST- 2021/11/02 00:00 [pmc-release]
AID - jpm11111137 [pii]
AID - jpm-11-01137 [pii]
AID - 10.3390/jpm11111137 [doi]
PST - epublish
SO  - J Pers Med. 2021 Nov 2;11(11):1137. doi: 10.3390/jpm11111137.