PMID- 34834527
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240404
IS  - 2075-4426 (Print)
IS  - 2075-4426 (Electronic)
IS  - 2075-4426 (Linking)
VI  - 11
IP  - 11
DP  - 2021 Nov 10
TI  - Interaction of Polygenetic Variants for Gestational Diabetes Mellitus Risk with 
      Breastfeeding and Korean Balanced Diet to Influence Type 2 Diabetes Risk in Later 
      Life in a Large Hospital-Based Cohort.
LID - 10.3390/jpm11111175 [doi]
LID - 1175
AB  - The etiologies of gestational diabetes mellitus (GDM) and type 2 diabetes 
      mellitus (T2DM) are similar. Genetic and environmental factors interact to 
      influence the risk of both types of diabetes. We aimed to determine if the 
      polygenetic risk scores (PRS) for GDM risk interacted with lifestyles to 
      influence type 2 diabetes risk in women aged >40 years in a large hospital-based 
      city cohort. The participants with GDM diagnosis without T2DM before pregnancy 
      were considered the case group (n = 384) and those without GDM and T2DM as the 
      control (n = 33,956) to explore GDM-related genetic variants. The participants 
      with T2DM were the case (n = 2550), and the control (n = 33,956) was the same as 
      GDM genetic analysis for the interaction analysis of GDM genetic risk with 
      lifestyles to influence T2DM risk. The genetic variants for the GDM risk were 
      selected from a genome-wide association study (GWAS), and their PRS from the best 
      model with gene-gene interactions were generated. GDM was positively associated 
      with age at first pregnancy, body mass index (BMI) at age 20, and education 
      level. A previous GDM diagnosis increased the likelihood of elevated fasting 
      serum glucose concentrations and HbA1c contents by 8.42 and 9.23 times in 
      middle-aged and older women. However, it was not associated with the risk of any 
      other metabolic syndrome components. Breast-feeding (>/=1 year) was inversely 
      associated with the T2DM risk in later life. In the genetic variant-genetic 
      variant interaction, the best model with 5-SNPs included PTPRD_rs916855529, 
      GPC6_rs9589710, CDKAL1_rs7754840, PRKAG2_rs11975504, and PTPRM_rs80164908. The 
      PRS calculated from the 5-SNP model was positively associated with the GDM risk 
      by 3.259 (2.17-4.89) times after adjusting GDM-related covariates. The GDM 
      experience interacted with PRS for the T2DM risk. Only in non-GDM women PRS was 
      positively associated with T2DM risk by 1.36-times. However, long breastfeeding 
      did not interact with the PRS for T2DM risk. Among dietary patterns, only a 
      Korean-style balanced diet (KBD) showed an interaction with PRS for the T2DM 
      risk. Participants with a low-PRS had the lowest serum glucose concentrations in 
      the high KBD intake but not low KBD intake. In conclusion, participants with a 
      high PRS for GDM risk are positively associated with T2DM risk, and breastfeeding 
      for >/=1 year and consuming KBD offset the PRS for GDM risk to influence T2DM risk 
      in middle-aged and older.
FAU - Park, Sunmin
AU  - Park S
AUID- ORCID: 0000-0002-6092-8340
AD  - Obesity/Diabetes Research Center, Department of Food and Nutrition, Institute of 
      Basic Science, Hoseo University, YejunBio, 165 Sechul-Ri, BaeBang-Yup Asan-Si, 
      ChungNam-Do, Asan 336-795, Korea.
LA  - eng
GR  - E0210501-01/Research Program of the Korea Food Research Institute (KFRI), funded 
      by the Ministry of Science and ICT/
PT  - Journal Article
DEP - 20211110
PL  - Switzerland
TA  - J Pers Med
JT  - Journal of personalized medicine
JID - 101602269
PMC - PMC8619899
OTO - NOTNLM
OT  - Korean balanced diet
OT  - beast-feeding
OT  - genetic variants
OT  - gestational diabetes mellitus
OT  - prepregnant age
OT  - type 2 diabetes
COIS- The author has no potential conflict of interest.
EDAT- 2021/11/28 06:00
MHDA- 2021/11/28 06:01
PMCR- 2021/11/10
CRDT- 2021/11/27 01:25
PHST- 2021/09/18 00:00 [received]
PHST- 2021/11/02 00:00 [revised]
PHST- 2021/11/09 00:00 [accepted]
PHST- 2021/11/27 01:25 [entrez]
PHST- 2021/11/28 06:00 [pubmed]
PHST- 2021/11/28 06:01 [medline]
PHST- 2021/11/10 00:00 [pmc-release]
AID - jpm11111175 [pii]
AID - jpm-11-01175 [pii]
AID - 10.3390/jpm11111175 [doi]
PST - epublish
SO  - J Pers Med. 2021 Nov 10;11(11):1175. doi: 10.3390/jpm11111175.