PMID- 34834528
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211130
IS  - 2075-4426 (Print)
IS  - 2075-4426 (Electronic)
IS  - 2075-4426 (Linking)
VI  - 11
IP  - 11
DP  - 2021 Nov 11
TI  - Very Long-Term Follow-Up in Cardiac Resynchronization Therapy: Wider Paced QRS 
      Equals Worse Prognosis.
LID - 10.3390/jpm11111176 [doi]
LID - 1176
AB  - BACKGROUND: Different electrocardiogram (ECG) findings are known to be 
      independent predictors of clinical response to cardiac resynchronization therapy 
      (CRT). It remains unknown how these findings influence very long-term prognosis. 
      METHODS AND RESULTS: A total of 102 consecutive patients (75 males, mean age 65 +/- 
      10 years) referred to our center for CRT implantation had previously been 
      included in this prospective observational study. The same patient group was now 
      re-evaluated for death from all causes over a prolonged median follow-up of 10.3 
      years (interquartile range 9.4-12.5 years). During follow-up, 55 patients died, 
      and 82% of the clinical non-responders (n = 23) and 44% of the responders (n = 
      79) were deceased. We screened for univariate associations and found QRS width 
      during biventricular (BIV) pacing (p = 0.02), left ventricular (LV) pacing (p < 
      0.01), Delta LV paced-right ventricular (RV) paced (p = 0.03), age (p = 0.03), New 
      York Heart Association (NYHA) class (p < 0.01), CHA(2)DS(2)-Vasc score (p < 
      0.01), glomerular filtration rate (p < 0.01), coronary artery disease (p < 0.01), 
      non-ischemic cardiomyopathy (NICM) (p = 0.01), arterial hypertension (p < 0.01), 
      NT-proBNP (p < 0.01), and clinical response to CRT (p < 0.01) to be significantly 
      associated with mortality. In the multivariate analysis, NICM, the lower NYHA 
      class, and smaller QRS width during BIV pacing were independent predictors of 
      better outcomes. CONCLUSION: Our data show that QRS width duration during 
      biventricular pacing, an ECG parameter easily obtainable during LV lead 
      placement, is an independent predictor of mortality in a long-term follow-up. Our 
      data add further evidence that NICM and lower NYHA class are independent 
      predictors for better outcome after CRT implantation.
FAU - Leitz, Patrick
AU  - Leitz P
AD  - Department of Cardiology II-Electrophysiology, Albert-Schweitzer-Campus 1, 
      University Hospital Muenster, 48149 Muenster, Germany.
FAU - Kobe, Julia
AU  - Kobe J
AUID- ORCID: 0000-0002-5877-352X
AD  - Department of Cardiology II-Electrophysiology, Albert-Schweitzer-Campus 1, 
      University Hospital Muenster, 48149 Muenster, Germany.
FAU - Rath, Benjamin
AU  - Rath B
AD  - Department of Cardiology II-Electrophysiology, Albert-Schweitzer-Campus 1, 
      University Hospital Muenster, 48149 Muenster, Germany.
FAU - Reinke, Florian
AU  - Reinke F
AD  - Department of Cardiology II-Electrophysiology, Albert-Schweitzer-Campus 1, 
      University Hospital Muenster, 48149 Muenster, Germany.
FAU - Frommeyer, Gerrit
AU  - Frommeyer G
AUID- ORCID: 0000-0002-1431-9886
AD  - Department of Cardiology II-Electrophysiology, Albert-Schweitzer-Campus 1, 
      University Hospital Muenster, 48149 Muenster, Germany.
FAU - Andresen, Christian
AU  - Andresen C
AD  - Department of Cardiology II-Electrophysiology, Albert-Schweitzer-Campus 1, 
      University Hospital Muenster, 48149 Muenster, Germany.
FAU - Guner, Fatih
AU  - Guner F
AD  - Department of Cardiology II-Electrophysiology, Albert-Schweitzer-Campus 1, 
      University Hospital Muenster, 48149 Muenster, Germany.
FAU - Wolfes, Julian
AU  - Wolfes J
AD  - Department of Cardiology II-Electrophysiology, Albert-Schweitzer-Campus 1, 
      University Hospital Muenster, 48149 Muenster, Germany.
FAU - Lange, Philipp S
AU  - Lange PS
AD  - Department of Cardiology II-Electrophysiology, Albert-Schweitzer-Campus 1, 
      University Hospital Muenster, 48149 Muenster, Germany.
FAU - Ellermann, Christian
AU  - Ellermann C
AUID- ORCID: 0000-0002-9172-296X
AD  - Department of Cardiology II-Electrophysiology, Albert-Schweitzer-Campus 1, 
      University Hospital Muenster, 48149 Muenster, Germany.
FAU - Eckardt, Lars
AU  - Eckardt L
AD  - Department of Cardiology II-Electrophysiology, Albert-Schweitzer-Campus 1, 
      University Hospital Muenster, 48149 Muenster, Germany.
FAU - Dechering, Dirk G
AU  - Dechering DG
AD  - Department of Cardiology II-Electrophysiology, Albert-Schweitzer-Campus 1, 
      University Hospital Muenster, 48149 Muenster, Germany.
LA  - eng
PT  - Journal Article
DEP - 20211111
PL  - Switzerland
TA  - J Pers Med
JT  - Journal of personalized medicine
JID - 101602269
PMC - PMC8620956
OTO - NOTNLM
OT  - ECG
OT  - cardiac resynchronization
OT  - heart failure
OT  - pacing
OT  - very long-term follow-up
COIS- The authors declare that they have no competing interest.
EDAT- 2021/11/28 06:00
MHDA- 2021/11/28 06:01
PMCR- 2021/11/11
CRDT- 2021/11/27 01:25
PHST- 2021/09/29 00:00 [received]
PHST- 2021/11/08 00:00 [revised]
PHST- 2021/11/09 00:00 [accepted]
PHST- 2021/11/27 01:25 [entrez]
PHST- 2021/11/28 06:00 [pubmed]
PHST- 2021/11/28 06:01 [medline]
PHST- 2021/11/11 00:00 [pmc-release]
AID - jpm11111176 [pii]
AID - jpm-11-01176 [pii]
AID - 10.3390/jpm11111176 [doi]
PST - epublish
SO  - J Pers Med. 2021 Nov 11;11(11):1176. doi: 10.3390/jpm11111176.