PMID- 34835927
OWN - NLM
STAT- MEDLINE
DCOM- 20211209
LR  - 20211214
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 13
IP  - 11
DP  - 2021 Oct 20
TI  - alpha(1)-Acid Glycoprotein and Dietary Intake in End-Stage Renal Disease Patients.
LID - 10.3390/nu13113671 [doi]
LID - 3671
AB  - Management of end-stage renal disease (ESRD) patients requires monitoring each of 
      the components of malnutrition-inflammation-atherosclerosis (MIA) syndrome. 
      Restrictive diet can negatively affect nutritional status and inflammation. An 
      acute-phase protein-alpha(1)-acid glycoprotein (AGP), has been associated with energy 
      metabolism in animal and human studies. The aim of our study was to look for a 
      relationship between serum AGP concentrations, laboratory parameters, and 
      nutrient intake in ESRD patients. The study included 59 patients treated with 
      maintenance hemodialysis. A 24 h recall assessed dietary intake during four 
      non-consecutive days-two days in the post-summer period, and two post-winter. 
      Selected laboratory tests were performed: complete blood count, serum iron, total 
      iron biding capacity (TIBC) and unsaturated iron biding capacity (UIBC), vitamin 
      D, AGP, C-reactive protein (CRP), albumin, prealbumin, and phosphate-calcium 
      metabolism markers (intact parathyroid hormone, calcium, phosphate). Recorded 
      dietary intake was highly deficient. A majority of patients did not meet 
      recommended daily requirements for energy, protein, fiber, iron, magnesium, 
      folate, and vitamin D. AGP correlated positively with CRP (R = 0.66), platelets 
      (R = 0.29), and negatively with iron (R = -0.27) and TIBC (R = -0.30). AGP 
      correlated negatively with the dietary intake of plant protein (R = -0.40), 
      potassium (R = -0.27), copper (R = -0.30), vitamin B(6) (R = -0.27), and folates 
      (R = -0.27), p < 0.05. However, in multiple regression adjusted for confounders, 
      only CRP was significantly associated with AGP. Our results indicate that in 
      hemodialyzed patients, serum AGP is weakly associated with dietary intake of 
      several nutrients, including plant protein.
FAU - Maraj, Malgorzata
AU  - Maraj M
AUID- ORCID: 0000-0002-8190-2481
AD  - Department of Physiology, Faculty of Medicine, Jagiellonian University Medical 
      College, Grzegorzecka 16 St., 31-531 Krakow, Poland.
FAU - Hetwer, Paulina
AU  - Hetwer P
AD  - Faculty of Medicine, Dietetics, Jagiellonian University Medical College, Anny 12 
      St., 31-008 Krakow, Poland.
FAU - Kusnierz-Cabala, Beata
AU  - Kusnierz-Cabala B
AD  - Chair of Clinical Biochemistry, Department of Diagnostics, Faculty of Medicine, 
      Jagiellonian University Medical College, Skawinska 8 St., 31-066 Krakow, Poland.
FAU - Maziarz, Barbara
AU  - Maziarz B
AD  - Chair of Clinical Biochemistry, Department of Diagnostics, Faculty of Medicine, 
      Jagiellonian University Medical College, Skawinska 8 St., 31-066 Krakow, Poland.
FAU - Dumnicka, Paulina
AU  - Dumnicka P
AUID- ORCID: 0000-0003-3667-857X
AD  - Department of Medical Diagnostics, Faculty of Pharmacy, Jagiellonian University 
      Medical College, Medyczna 9 St., 30-688 Krakow, Poland.
FAU - Kuzniewski, Marek
AU  - Kuzniewski M
AD  - Chair and Department of Nephrology, Faculty of Medicine, Jagiellonian University 
      Medical College, Jakubowskiego 2 St., 30-688 Krakow, Poland.
FAU - Ceranowicz, Piotr
AU  - Ceranowicz P
AUID- ORCID: 0000-0003-3478-0108
AD  - Department of Physiology, Faculty of Medicine, Jagiellonian University Medical 
      College, Grzegorzecka 16 St., 31-531 Krakow, Poland.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20211020
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Biomarkers)
RN  - 0 (Orosomucoid)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Biomarkers/blood
MH  - C-Reactive Protein/analysis
MH  - Diet/adverse effects/statistics & numerical data
MH  - Diet Records
MH  - Eating/*physiology
MH  - Female
MH  - Humans
MH  - Inflammation
MH  - Kidney Failure, Chronic/complications/*physiopathology/therapy
MH  - Male
MH  - Malnutrition/*blood/etiology
MH  - Middle Aged
MH  - Nutritional Status
MH  - Orosomucoid/*analysis/deficiency
MH  - Prospective Studies
MH  - Recommended Dietary Allowances
MH  - Regression Analysis
MH  - Renal Dialysis/*adverse effects
PMC - PMC8621909
OTO - NOTNLM
OT  - appetite
OT  - dietary intake
OT  - end-stage kidney disease
OT  - hemodialysis
OT  - malnutrition
OT  - alpha1-acid glycoprotein
COIS- Authors declare no conflict of interest. The funders had no role in the design of 
      the study; in the collection, analyses, or interpretation of data; in the writing 
      of the manuscript, or in the decision to publish the results.
EDAT- 2021/11/28 06:00
MHDA- 2021/12/15 06:00
PMCR- 2021/10/20
CRDT- 2021/11/27 01:29
PHST- 2021/09/06 00:00 [received]
PHST- 2021/10/12 00:00 [revised]
PHST- 2021/10/13 00:00 [accepted]
PHST- 2021/11/27 01:29 [entrez]
PHST- 2021/11/28 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/10/20 00:00 [pmc-release]
AID - nu13113671 [pii]
AID - nutrients-13-03671 [pii]
AID - 10.3390/nu13113671 [doi]
PST - epublish
SO  - Nutrients. 2021 Oct 20;13(11):3671. doi: 10.3390/nu13113671.