PMID- 34836497
OWN - NLM
STAT- MEDLINE
DCOM- 20211130
LR  - 20211130
IS  - 1471-2377 (Electronic)
IS  - 1471-2377 (Linking)
VI  - 21
IP  - 1
DP  - 2021 Nov 27
TI  - Autoimmune encephalitis with coexistent LGI1 and GABA(B)R1 antibodies: case 
      report.
PG  - 461
LID - 10.1186/s12883-021-02460-w [doi]
LID - 461
AB  - BACKGROUND: Autoimmune encephalitis (AE) with multiple auto-antibodies is of 
      great clinical significance because its complex clinical manifestations and 
      atypical imaging increase the difficulty of diagnosis, differential diagnosis and 
      treatment, which may aggravate the disease, increase the recurrence rate and 
      mortality. The coexistence of anti-Leucinie-rich Glioma Inactivated 1 (LGI1) and 
      anti-gamma-aminobutyric acid-beta-receptor 1 (GABA(B)R1) has not been published 
      before. CASE PRESENTATION: We herein present the case of a 60-year-old man with 
      slow response, behavioral changes, psychosis and sleep disorders. Laboratory test 
      included serum hyponatremia, positive serum LGI1 and GABA(B)R1 antibodies using 
      transfected cell-based assays. Electroencephalogram exhibited moderate diffusion 
      abnormality. The patient responded well to steroid impulse treatment and sodium 
      supplement therapy, and did not recur during the follow-up. CONCLUSIONS: Here we 
      report the first AE characterized by positive LGI1 and GABA(B)R1 antibodies, as 
      well as summarizing AE with multiple auto-antibodies reported so far, hopefully 
      to provide experience for clinical practice.
CI  - (c) 2021. The Author(s).
FAU - Xie, Yi
AU  - Xie Y
AD  - Department of Neurology, The First Affiliated Hospital of Zhengzhou University, 
      Zhengzhou, 450052, China.
FAU - Wen, Jia
AU  - Wen J
AD  - Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, 
      Zhengzhou, 450052, China.
FAU - Zhao, Zhihua
AU  - Zhao Z
AD  - Department of Neurology, The First Affiliated Hospital of Zhengzhou University, 
      Zhengzhou, 450052, China.
FAU - Liu, Hongbo
AU  - Liu H
AD  - Department of Neurology, The First Affiliated Hospital of Zhengzhou University, 
      Zhengzhou, 450052, China.
FAU - Xie, Nanchang
AU  - Xie N
AD  - Department of Neurology, The First Affiliated Hospital of Zhengzhou University, 
      Zhengzhou, 450052, China. xienanchang2001@163.com.
LA  - eng
GR  - 2018020114/the Joint Construction Project of Henan Province and the First 
      Affiliated Hospital of Zhengzhou University/
GR  - 2018020083/the Joint Construction Project of Henan Province and the First 
      Affiliated Hospital of Zhengzhou University/
GR  - 81971214/National Natural Science Foundation of China/
PT  - Case Reports
PT  - Journal Article
DEP - 20211127
PL  - England
TA  - BMC Neurol
JT  - BMC neurology
JID - 100968555
RN  - 0 (Autoantibodies)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (LGI1 protein, human)
RN  - Hashimoto's encephalitis
SB  - IM
MH  - Autoantibodies
MH  - Encephalitis
MH  - *Glioma
MH  - Hashimoto Disease
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins
MH  - *Limbic Encephalitis
MH  - Male
MH  - Middle Aged
PMC - PMC8626930
OTO - NOTNLM
OT  - Anti- GABABR1
OT  - Anti-LGI1
OT  - Autoimmune encephalitis
OT  - Multiple auto-antibody
COIS- All authors claimed that there were no conflicts of interest. The above funding 
      bodies played a role in the analysis and interpretation of data.
EDAT- 2021/11/28 06:00
MHDA- 2021/12/01 06:00
PMCR- 2021/11/27
CRDT- 2021/11/27 05:18
PHST- 2020/11/17 00:00 [received]
PHST- 2021/10/22 00:00 [accepted]
PHST- 2021/11/27 05:18 [entrez]
PHST- 2021/11/28 06:00 [pubmed]
PHST- 2021/12/01 06:00 [medline]
PHST- 2021/11/27 00:00 [pmc-release]
AID - 10.1186/s12883-021-02460-w [pii]
AID - 2460 [pii]
AID - 10.1186/s12883-021-02460-w [doi]
PST - epublish
SO  - BMC Neurol. 2021 Nov 27;21(1):461. doi: 10.1186/s12883-021-02460-w.