PMID- 34837534
OWN - NLM
STAT- MEDLINE
DCOM- 20220614
LR  - 20220725
IS  - 1435-1463 (Electronic)
IS  - 0300-9564 (Linking)
VI  - 129
IP  - 5-6
DP  - 2022 Jun
TI  - Cognition, motor symptoms, and glycolipid metabolism in Parkinson's disease with 
      depressive symptoms.
PG  - 563-573
LID - 10.1007/s00702-021-02437-6 [doi]
AB  - Depressive symptoms and abnormal glycolipid metabolisms are common in patients 
      with Parkinson's disease (PD), but their relationship has not been fully 
      reported. It is not clear whether glycolipid impairments lead to poor cognitive 
      and motor function, and aggravate depressive symptoms. Therefore, we aimed to 
      explore the relationships between glycolipid variables, cognition, motor and 
      depressive symptoms in PD patients cross-sectionally. Two hundred ten PD patients 
      were recruited. Glycolipid parameters and Uric acid (UA) were measured. 
      Depressive symptoms, cognitive function and motor symptoms were assessed using 
      the Hamilton Depression Rating Scale-17 (HAMD-17), the Montreal Cognitive 
      Assessment (MOCA) and the Movement Disorder Society Unified Parkinson's Disease 
      Rating Scale Part-III (UPDRS-III). Depressive PD patients had significantly worse 
      motor symptoms and higher levels of fasting plasma glucose (FPG) than those in 
      non-depressive patients (F = 24.145, P < 0.001). Further, logistic regression 
      analysis indicated that UPDRS-III (OR = 1.039, 95% CI 1.019-1.057, P = 0.044), 
      FPG (OR = 1.447, 95% CI 1.050-1.994, P = 0.024) were independently associated 
      with depression. In PD patients without depression, UA (beta = - 0.068, t = - 2.913, 
      P = 0.005) and cholesterol (CHOL) (beta = - 3.941, t = - 2.518, P = 0.014) were 
      independent predictors of the UPDRS-III score; in addition, UPDRS-III score was 
      negatively associated with MOCA score (beta = - 0.092, t = - 2.791, P = 0.007). FPG 
      levels and motor symptoms were related to depressive symptoms in PD patients. 
      Further, in non-depressive PD patients, UA and CHOL showed putative biomarkers of 
      motor symptoms.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, 
      part of Springer Nature.
FAU - Yao, Cong
AU  - Yao C
AD  - Laboratory of Biological Psychiatry, Institute of Mental Health, Tianjin Anding 
      Hospital, Mental Health Center of Tianjin Medical University, 13 Liulin Road, 
      Hexi District, 300222, Tianjin, China.
FAU - Niu, Lichao
AU  - Niu L
AD  - Laboratory of Biological Psychiatry, Institute of Mental Health, Tianjin Anding 
      Hospital, Mental Health Center of Tianjin Medical University, 13 Liulin Road, 
      Hexi District, 300222, Tianjin, China.
FAU - Fu, Yun
AU  - Fu Y
AD  - Department of Genetics, College of Basic Medical Sciences, Tianjin Medical 
      University, Tianjin, 300070, China.
FAU - Zhu, Xu
AU  - Zhu X
AD  - Department of Genetics, College of Basic Medical Sciences, Tianjin Medical 
      University, Tianjin, 300070, China.
AD  - Department of Psychiatry and Psychology, College of Basic Medical Sciences, 
      Tianjin Medical University, 22 Qixiangtai Roads, Heping District, Tianjin, 
      300070, China.
FAU - Yang, Junfeng
AU  - Yang J
AD  - Department of Neurology, Tianjin Medical University General Hospital, Tianjin, 
      300052, China.
FAU - Zhao, Peng
AU  - Zhao P
AD  - Department of Neurology, Tianjin Medical University General Hospital, Tianjin, 
      300052, China.
FAU - Sun, Xiaoxiao
AU  - Sun X
AD  - Laboratory of Biological Psychiatry, Institute of Mental Health, Tianjin Anding 
      Hospital, Mental Health Center of Tianjin Medical University, 13 Liulin Road, 
      Hexi District, 300222, Tianjin, China.
FAU - Ma, Yanyan
AU  - Ma Y
AD  - Laboratory of Biological Psychiatry, Institute of Mental Health, Tianjin Anding 
      Hospital, Mental Health Center of Tianjin Medical University, 13 Liulin Road, 
      Hexi District, 300222, Tianjin, China.
FAU - Li, Shen
AU  - Li S
AD  - Laboratory of Biological Psychiatry, Institute of Mental Health, Tianjin Anding 
      Hospital, Mental Health Center of Tianjin Medical University, 13 Liulin Road, 
      Hexi District, 300222, Tianjin, China. lishen@tmu.edu.cn.
AD  - Department of Psychiatry and Psychology, College of Basic Medical Sciences, 
      Tianjin Medical University, 22 Qixiangtai Roads, Heping District, Tianjin, 
      300070, China. lishen@tmu.edu.cn.
FAU - Li, Jie
AU  - Li J
AD  - Laboratory of Biological Psychiatry, Institute of Mental Health, Tianjin Anding 
      Hospital, Mental Health Center of Tianjin Medical University, 13 Liulin Road, 
      Hexi District, 300222, Tianjin, China. jieli@tjmhc.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211127
PL  - Austria
TA  - J Neural Transm (Vienna)
JT  - Journal of neural transmission (Vienna, Austria : 1996)
JID - 9702341
RN  - 0 (Glycolipids)
RN  - 268B43MJ25 (Uric Acid)
SB  - IM
MH  - Cognition
MH  - Depression/complications
MH  - Glycolipids
MH  - Humans
MH  - Mental Status and Dementia Tests
MH  - *Parkinson Disease
MH  - Uric Acid
OTO - NOTNLM
OT  - Cognition
OT  - Depressive symptoms
OT  - Glycolipid metabolism
OT  - Motor symptoms
OT  - Parkinson's disease
EDAT- 2021/11/28 06:00
MHDA- 2022/06/15 06:00
CRDT- 2021/11/27 12:05
PHST- 2021/09/30 00:00 [received]
PHST- 2021/10/29 00:00 [accepted]
PHST- 2021/11/28 06:00 [pubmed]
PHST- 2022/06/15 06:00 [medline]
PHST- 2021/11/27 12:05 [entrez]
AID - 10.1007/s00702-021-02437-6 [pii]
AID - 10.1007/s00702-021-02437-6 [doi]
PST - ppublish
SO  - J Neural Transm (Vienna). 2022 Jun;129(5-6):563-573. doi: 
      10.1007/s00702-021-02437-6. Epub 2021 Nov 27.