PMID- 34837624
OWN - NLM
STAT- MEDLINE
DCOM- 20230310
LR  - 20230310
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 30
IP  - 10
DP  - 2023 Feb
TI  - Associations of bisphenol exposure with the risk of gestational diabetes 
      mellitus: a nested case-control study in Guangxi, China.
PG  - 25170-25180
LID - 10.1007/s11356-021-17794-8 [doi]
AB  - A growing number of epidemiologic studies have estimated the associations between 
      endocrine-disrupting chemicals and gestational diabetes mellitus (GDM). However, 
      reports on the association between bisphenol A (BPA) substitutes and GDM are 
      limited. This investigation aimed to explore the associations of maternal serum 
      BPA, bisphenol B (BPB), bisphenol F (BPF), bisphenol S (BPS), and 
      tetrabromobisphenol A (TBBPA) with the risk of GDM. A nested case-control study 
      was performed among 500 pregnant women. In conditional logistic regression 
      models, the OR for BPS was significantly increased in the medium exposure groups 
      (OR = 1.77; 95% CI: 1.01, 3.13) compared with the reference group, while BPA (OR: 
      0.38, 95%CI: 0.29, 0.50) and TBBPA (OR: 0.67, 95%CI: 0.54, 0.85) were negatively 
      associated with the risk of GDM. In the Bayesian kernel machine regression (BKMR) 
      analysis, the joint effect of bisphenols was positively associated with the risk 
      of GDM. BPS showed positively relationship, while BPA and TBBPA showed negatively 
      relationship, respectively. The quantile g-computation revealed a statistically 
      significant and negative joint effect of the five bisphenols on the risk of GDM 
      (OR: 0.57; 95% CI: 0.46, 0.72) with BPA (70.2%), TBBPA (21.3%), and BPB (8.5%) 
      had positive contribution to the overall effect. These findings suggested that 
      BPS had a positive effect on the risk of GDM, while BPA and TBBPA had negative 
      effect on the risk of GDM. Moreover, exposure to the mixture of the five 
      bisphenols was negatively associated with the risk of GDM.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Tang, Peng
AU  - Tang P
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Guangxi Medical University, No. 22 Shuangyong Road, Nanning, 530021, Guangxi, 
      China.
FAU - Liang, Jun
AU  - Liang J
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Guangxi Medical University, No. 22 Shuangyong Road, Nanning, 530021, Guangxi, 
      China.
FAU - Liao, Qian
AU  - Liao Q
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Guangxi Medical University, No. 22 Shuangyong Road, Nanning, 530021, Guangxi, 
      China.
FAU - Huang, Huishen
AU  - Huang H
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Guangxi Medical University, No. 22 Shuangyong Road, Nanning, 530021, Guangxi, 
      China.
FAU - Guo, Xiaojing
AU  - Guo X
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Guangxi Medical University, No. 22 Shuangyong Road, Nanning, 530021, Guangxi, 
      China.
FAU - Lin, Mengrui
AU  - Lin M
AD  - Department of Sanitary Chemistry, School of Public Health, Guangxi Medical 
      University, No. 22 Shuangyong Road, Nanning, 530021, Guangxi, China.
FAU - Liu, Bihu
AU  - Liu B
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Guangxi Medical University, No. 22 Shuangyong Road, Nanning, 530021, Guangxi, 
      China.
FAU - Wei, Bincai
AU  - Wei B
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Guangxi Medical University, No. 22 Shuangyong Road, Nanning, 530021, Guangxi, 
      China.
FAU - Zeng, Xiaoyun
AU  - Zeng X
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Guangxi Medical University, No. 22 Shuangyong Road, Nanning, 530021, Guangxi, 
      China.
FAU - Liu, Shun
AU  - Liu S
AD  - Department of Maternal, Child and Adolescent Health, School of Public Health, 
      Guangxi Medical University, No. 22 Shuangyong Road, Nanning, 530021, Guangxi, 
      China. liushun@gxmu.edu.cn.
FAU - Huang, Dongping
AU  - Huang D
AD  - Department of Sanitary Chemistry, School of Public Health, Guangxi Medical 
      University, No. 22 Shuangyong Road, Nanning, 530021, Guangxi, China. 
      dongpinghuang@gxmu.edu.cn.
FAU - Qiu, Xiaoqiang
AU  - Qiu X
AUID- ORCID: 0000-0001-9881-3664
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Guangxi Medical University, No. 22 Shuangyong Road, Nanning, 530021, Guangxi, 
      China. xqqiu9999@163.com.
LA  - eng
GR  - AB17195012/Guangxi Key Research Program/
GR  - 81860587/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20211127
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - MLT3645I99 (bisphenol A)
RN  - 1RC731TJJA (bisphenol B)
RN  - 0 (Benzhydryl Compounds)
RN  - 80-09-1 (bis(4-hydroxyphenyl)sulfone)
SB  - IM
MH  - Humans
MH  - Pregnancy
MH  - Female
MH  - *Diabetes, Gestational/chemically induced/epidemiology
MH  - Case-Control Studies
MH  - Bayes Theorem
MH  - China/epidemiology
MH  - Benzhydryl Compounds
OTO - NOTNLM
OT  - Bisphenol
OT  - Gestational diabetes mellitus
OT  - Joint effect models
OT  - Nested case-control study
EDAT- 2021/11/28 06:00
MHDA- 2023/03/11 06:00
CRDT- 2021/11/27 12:08
PHST- 2021/08/31 00:00 [received]
PHST- 2021/11/23 00:00 [accepted]
PHST- 2021/11/28 06:00 [pubmed]
PHST- 2023/03/11 06:00 [medline]
PHST- 2021/11/27 12:08 [entrez]
AID - 10.1007/s11356-021-17794-8 [pii]
AID - 10.1007/s11356-021-17794-8 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2023 Feb;30(10):25170-25180. doi: 
      10.1007/s11356-021-17794-8. Epub 2021 Nov 27.