PMID- 34837792
OWN - NLM
STAT- MEDLINE
DCOM- 20220311
LR  - 20220311
IS  - 1872-6976 (Electronic)
IS  - 0167-4943 (Linking)
VI  - 99
DP  - 2022 Mar-Apr
TI  - Astragalus membranaceus treatment combined with caloric restriction may enhance 
      genesis factors and decrease apoptosis in the hippocampus of rats.
PG  - 104584
LID - S0167-4943(21)00247-8 [pii]
LID - 10.1016/j.archger.2021.104584 [doi]
AB  - Humans have been searching for ways of extending life span, and possible 
      underlying molecular mechanisms behind it for many years. Traditional plants and 
      their extracts are good candidates for finding anti-aging strategies. In addition 
      to its usage in a variety of medical treatments such as inflammation, neural 
      diseases and cancer, Astragalus membranaceus was used to extend lifespan of C. 
      elegans. Therefore, we aimed to show the molecular mechanisms of the possible 
      anti-aging effects of combination of A. membranaceus and caloric restriction. 
      Herein, Wistar rats (n = 24) were divided into Control, A. membranaceus (A) 
      (25 mg/kg A), Caloric restriction (CR) (20% restricted-diet), and CR+A (25 mg/kg 
      A + 20% CR diet) groups. After 18 weeks, behavioral tests were applied to observe 
      alterations on cognitive functions. After animals were decapitated, their 
      hippocampi and livers were dissected for molecular analysis and telomerase 
      activity. Eventually, CR increased learning performances of rats with an increase 
      in the telomerase activity when combined with astragalus. There was a negative 
      correlation between learning and apoptosis parameters. In the CR group, the 
      apoptosis rate increased, and the pyramidal neuron numbers decreased which were 
      reached to control levels with A treatment. The CR+A treatment significantly 
      increased the BDNF level. The A also significantly increased GDNF level 
      independent from CR. In the combination group, the neurogenesis and angiogenesis 
      markers increased with an increase in the anti-senescence protein klotho land a 
      decrease in the apoptosis. In conclusion, combination of caloric restriction with 
      A. membranaceus would become a promising strategy for healthy cognitive aging.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Setel, Deniz Dilan
AU  - Setel DD
AD  - Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.
FAU - Beker, Merve
AU  - Beker M
AD  - Department of Medical Biology, Hamidiye International School of Medicine, 
      University of Health Sciences Turkey, Istanbul, Turkey.
FAU - Terzioglu-Usak, Sule
AU  - Terzioglu-Usak S
AD  - Department of Medical Biology, Faculty of Medicine, Bezmialem Vakif University, 
      Istanbul, Turkey.
FAU - Elibol, Birsen
AU  - Elibol B
AD  - Department of Medical Biology, Faculty of Medicine, Bezmialem Vakif University, 
      Istanbul, Turkey. Electronic address: b.can@bezmialem.edu.tr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211120
PL  - Netherlands
TA  - Arch Gerontol Geriatr
JT  - Archives of gerontology and geriatrics
JID - 8214379
SB  - IM
MH  - Aging/physiology
MH  - Animals
MH  - Apoptosis
MH  - *Astragalus propinquus
MH  - Caenorhabditis elegans
MH  - *Caloric Restriction
MH  - Hippocampus
MH  - Humans
MH  - Rats
MH  - Rats, Wistar
OTO - NOTNLM
OT  - Astragalus membranaceus
OT  - Caloric restriction
OT  - Hippocampus
OT  - Klotho
OT  - Neurogenesis
OT  - Rat
EDAT- 2021/11/28 06:00
MHDA- 2022/03/12 06:00
CRDT- 2021/11/27 20:08
PHST- 2021/09/30 00:00 [received]
PHST- 2021/11/08 00:00 [revised]
PHST- 2021/11/16 00:00 [accepted]
PHST- 2021/11/28 06:00 [pubmed]
PHST- 2022/03/12 06:00 [medline]
PHST- 2021/11/27 20:08 [entrez]
AID - S0167-4943(21)00247-8 [pii]
AID - 10.1016/j.archger.2021.104584 [doi]
PST - ppublish
SO  - Arch Gerontol Geriatr. 2022 Mar-Apr;99:104584. doi: 
      10.1016/j.archger.2021.104584. Epub 2021 Nov 20.