PMID- 34837997
OWN - NLM
STAT- MEDLINE
DCOM- 20211206
LR  - 20211214
IS  - 1471-2431 (Electronic)
IS  - 1471-2431 (Linking)
VI  - 21
IP  - 1
DP  - 2021 Nov 27
TI  - Eyelid ptosis and muscle weakness in a child with Kawasaki disease: a case 
      report.
PG  - 526
LID - 10.1186/s12887-021-02979-4 [doi]
LID - 526
AB  - BACKGROUND: Kawasaki disease (KD) is an acute febrile vasculitis that often 
      occurs in children under 5 years. Ptosis and muscle weakness associated with KD 
      are rarely documented. CASE PRESENTATION: We present a case of KD with eyelid 
      ptosis and muscle weakness in a 3-year-old boy. At admission, grade IV and grade 
      III muscle strength were recorded for upper and lower limbs, respectively. 
      Diminished patellar tendon reflex was noted. Laboratory evaluation showed 
      hypokalemia with the serum potassium concentration of 2.62 mmol/L. Intravenous 
      immunoglobulin (IVIG) and aspirin were initiated immediately accompanied with 
      methylprednisolone for adjunctive therapy. Potassium supplement was administered 
      at the same time, which resulted in the correction of hypokalemia on the 2nd day 
      of admission but no improvement in ptosis and muscle weakness. Neostigmine 
      testing, lumber puncture, electromyography, and cerebral and full spine MRI were 
      performed, which, however, did not find evidence for neural and muscle diseases. 
      On the 5th day, the fever was resolved. On the 6th day, eyelid ptosis 
      disappeared. And on the 14th day, the muscle strength and muscle tension returned 
      to normal, patellar tendon reflex could be drawn out normally, and the boy 
      regained full ambulatory ability. CONCLUSIONS: KD might affect the neural and 
      muscular systems, and KD complicated with eyelid ptosis and muscle weakness is 
      responsive to the standard anti-inflammatory treatment plus adjunctive 
      corticosteroid therapy.
CI  - (c) 2021. The Author(s).
FAU - Lin, Yao
AU  - Lin Y
AD  - Department of Pediatric Cardiology, Children's Hospital, Capital Institute of 
      Pediatrics, No. 2 Yabao Road, Chaoyang District, Beijing, 100020, China.
FAU - Wang, Lijun
AU  - Wang L
AD  - Department of Pediatric Cardiology, Children's Hospital, Capital Institute of 
      Pediatrics, No. 2 Yabao Road, Chaoyang District, Beijing, 100020, China.
FAU - Li, Aijie
AU  - Li A
AD  - Department of Pediatric Cardiology, Children's Hospital, Capital Institute of 
      Pediatrics, No. 2 Yabao Road, Chaoyang District, Beijing, 100020, China.
FAU - Zhang, Hongwei
AU  - Zhang H
AD  - Department of Pediatric Cardiology, Children's Hospital, Capital Institute of 
      Pediatrics, No. 2 Yabao Road, Chaoyang District, Beijing, 100020, China.
FAU - Shi, Lin
AU  - Shi L
AD  - Department of Pediatric Cardiology, Children's Hospital, Capital Institute of 
      Pediatrics, No. 2 Yabao Road, Chaoyang District, Beijing, 100020, China. 
      shilin9789@126.com.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20211127
PL  - England
TA  - BMC Pediatr
JT  - BMC pediatrics
JID - 100967804
RN  - 0 (Immunoglobulins, Intravenous)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Aspirin/therapeutic use
MH  - *Blepharoptosis/etiology
MH  - Child
MH  - Child, Preschool
MH  - Humans
MH  - Immunoglobulins, Intravenous/therapeutic use
MH  - Male
MH  - *Mucocutaneous Lymph Node Syndrome/complications/diagnosis/drug therapy
MH  - Muscle Weakness/etiology
PMC - PMC8626717
OTO - NOTNLM
OT  - Case report
OT  - Kawasaki disease
OT  - Muscle weakness
OT  - Myositis
OT  - Ptosis
COIS- All authors declare no competing interests.
EDAT- 2021/11/29 06:00
MHDA- 2021/12/15 06:00
PMCR- 2021/11/27
CRDT- 2021/11/28 20:26
PHST- 2021/07/14 00:00 [received]
PHST- 2021/10/28 00:00 [accepted]
PHST- 2021/11/28 20:26 [entrez]
PHST- 2021/11/29 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/11/27 00:00 [pmc-release]
AID - 10.1186/s12887-021-02979-4 [pii]
AID - 2979 [pii]
AID - 10.1186/s12887-021-02979-4 [doi]
PST - epublish
SO  - BMC Pediatr. 2021 Nov 27;21(1):526. doi: 10.1186/s12887-021-02979-4.