PMID- 34838765
OWN - NLM
STAT- MEDLINE
DCOM- 20220805
LR  - 20220822
IS  - 1878-8769 (Electronic)
IS  - 1878-8750 (Linking)
VI  - 158
DP  - 2022 Feb
TI  - Comparison of Outcomes Between Cage Materials Used for Patients Undergoing 
      Anterior Cervical Discectomy and Fusion with Standalone Cages: A Systematic 
      Review and Meta-Analysis.
PG  - e38-e54
LID - S1878-8750(21)01581-3 [pii]
LID - 10.1016/j.wneu.2021.10.084 [doi]
AB  - INTRODUCTION: Interbody cages are currently being used to address diseases of the 
      vertebra requiring surgical stabilization. Titanium cages were first introduced 
      in 1988. Polyetheretherketone (PEEK) cages are used frequently as one of the 
      alternatives to titanium cages in current practice. This study aimed to compare 
      available cage materials by reviewing the surgical and radiographic outcomes 
      following anterior cervical discectomy and fusion. METHODS: A comprehensive 
      search of several electronic databases was conducted following the PRISMA 
      (Preferred Reporting Items for Systematic reviews and Meta-Analyses) guidelines. 
      Baseline characteristics, operative outcomes, arthrodesis rates, subsidence 
      rates, and complications were collected from included studies. Collected outcomes 
      were further stratified according to the procedure type, the number of levels 
      operated, and graft used to compare cage materials. RESULTS: Following the 
      screening for inclusion criteria, a total of 37 studies with 2363 patients were 
      included. The median age was 49.5 years and the median follow-up was 26 months. 
      Overall, no significant differences were found between PEEK and titanium cages 
      regarding fusion, neurologic deficit, subsidence rates, or "good and excellent" 
      outcome according to Odom criteria. However, the standalone comparison between 
      PEEK, titanium, and poly-methyl-methacrylate (PMMA) cages showed a significantly 
      lower fusion rate for PMMA (PEEK: 94%, PMMA: 56%, titanium: 95%, P < 0.01). 
      CONCLUSIONS: In the present systematic review and meta-analysis, a comparison of 
      the long-term patient-reported and the radiographic outcomes associated with the 
      use of titanium and PEEK, intervertebral body cages showed similar findings. 
      However, there were significantly lower fusion rates for PMMA cages when using a 
      standalone cage without graft material.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Onyedimma, Chiduziem
AU  - Onyedimma C
AD  - Meharry Medical College, Nashville, Tennessee, USA; Neuro-Informatics Laboratory, 
      Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA; 
      Department of Neurological Surgery, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Jallow, Ousman
AU  - Jallow O
AD  - Meharry Medical College, Nashville, Tennessee, USA.
FAU - Yolcu, Yagiz U
AU  - Yolcu YU
AD  - Neuro-Informatics Laboratory, Mayo Clinic College of Medicine and Science, 
      Rochester, Minnesota, USA; Department of Neurological Surgery, Mayo Clinic, 
      Rochester, Minnesota, USA.
FAU - Alvi, Mohammed Ali
AU  - Alvi MA
AD  - Neuro-Informatics Laboratory, Mayo Clinic College of Medicine and Science, 
      Rochester, Minnesota, USA; Department of Neurological Surgery, Mayo Clinic, 
      Rochester, Minnesota, USA.
FAU - Goyal, Anshit
AU  - Goyal A
AD  - Neuro-Informatics Laboratory, Mayo Clinic College of Medicine and Science, 
      Rochester, Minnesota, USA; Department of Neurological Surgery, Mayo Clinic, 
      Rochester, Minnesota, USA.
FAU - Ghaith, Abdul Karim
AU  - Ghaith AK
AD  - Neuro-Informatics Laboratory, Mayo Clinic College of Medicine and Science, 
      Rochester, Minnesota, USA; Department of Neurological Surgery, Mayo Clinic, 
      Rochester, Minnesota, USA.
FAU - Bhatti, Atiq Ur Rehman
AU  - Bhatti AUR
AD  - Neuro-Informatics Laboratory, Mayo Clinic College of Medicine and Science, 
      Rochester, Minnesota, USA; Department of Neurological Surgery, Mayo Clinic, 
      Rochester, Minnesota, USA.
FAU - Abode-Iyamah, Kingsley
AU  - Abode-Iyamah K
AD  - Department of Neurological Surgery, Mayo Clinic, Jacksonville, Florida, USA.
FAU - Quinones-Hinojosa, Alfredo
AU  - Quinones-Hinojosa A
AD  - Department of Neurological Surgery, Mayo Clinic, Jacksonville, Florida, USA.
FAU - Freedman, Brett A
AU  - Freedman BA
AD  - Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Bydon, Mohamad
AU  - Bydon M
AD  - Neuro-Informatics Laboratory, Mayo Clinic College of Medicine and Science, 
      Rochester, Minnesota, USA; Department of Neurological Surgery, Mayo Clinic, 
      Rochester, Minnesota, USA. Electronic address: bydon.mohamad@mayo.edu.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20211124
PL  - United States
TA  - World Neurosurg
JT  - World neurosurgery
JID - 101528275
RN  - 0 (Ketones)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 9011-14-7 (Polymethyl Methacrylate)
RN  - D1JT611TNE (Titanium)
SB  - IM
MH  - Cervical Vertebrae/diagnostic imaging/surgery
MH  - Diskectomy/methods
MH  - Humans
MH  - Ketones/adverse effects
MH  - Middle Aged
MH  - Polyethylene Glycols
MH  - Polymethyl Methacrylate
MH  - *Spinal Fusion/methods
MH  - *Titanium/adverse effects
MH  - Treatment Outcome
OTO - NOTNLM
OT  - ACDF
OT  - Cage
OT  - PEEK
OT  - PMMA
OT  - Spine
OT  - Titanium
EDAT- 2021/11/29 06:00
MHDA- 2022/08/06 06:00
CRDT- 2021/11/28 20:52
PHST- 2021/08/25 00:00 [received]
PHST- 2021/10/05 00:00 [revised]
PHST- 2021/10/06 00:00 [accepted]
PHST- 2021/11/29 06:00 [pubmed]
PHST- 2022/08/06 06:00 [medline]
PHST- 2021/11/28 20:52 [entrez]
AID - S1878-8750(21)01581-3 [pii]
AID - 10.1016/j.wneu.2021.10.084 [doi]
PST - ppublish
SO  - World Neurosurg. 2022 Feb;158:e38-e54. doi: 10.1016/j.wneu.2021.10.084. Epub 2021 
      Nov 24.