PMID- 34838902
OWN - NLM
STAT- MEDLINE
DCOM- 20220926
LR  - 20220926
IS  - 1535-6280 (Electronic)
IS  - 0146-2806 (Linking)
VI  - 47
IP  - 11
DP  - 2022 Nov
TI  - Successful Use of Intravenous B-blocker Therapy in Cardiogenic Shock Supported 
      With Venoarterial Extracorporeal Membrane Oxygenation: A Case Series.
PG  - 101071
LID - S0146-2806(21)00279-6 [pii]
LID - 10.1016/j.cpcardiol.2021.101071 [doi]
AB  - Tachycardia in cardiogenic shock (CS) might reduce the cardiac output (CO) by 
      decreasing the ventricular filling time. Nevertheless, heart rate (HR) control 
      with agents that possess negative inotropy might decrease the CO. Therefore, 
      controlling the tachycardia in the setting of CS remains controversial. We herein 
      describe four cases of patients presenting with myocardial infarction complicated 
      with CS that required rescue venoarterial extracorporeal membrane oxygenation 
      (VA-ECMO) initiation. Tachycardia was present with HR  approximately 130-140 beats per minute 
      after VA-ECMO initiation, and hence esmolol was infused continuously at a 
      starting dose of 10-20 mcg/kg/min and titrated according to HR. With the use of 
      esmolol to control the HR in the setting of CS supported with VA-ECMO, lactate 
      cleared, and echocardiographic parameters improved, allowing the four cases to be 
      successfully decannulated from ECMO. Our report indicates that short-acting 
      beta-blocker could be safely used in the complex scenario of severe tachycardia 
      while supported with VA-ECMO.
CI  - Copyright (c) 2021 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Rahhal, Alaa
AU  - Rahhal A
AD  - Department of Pharmacy, Heart Hospital, Hamad Medical Corporation, Doha, Qatar. 
      Electronic address: arahhal1@hamad.qa.
FAU - Omar, Amr Salah
AU  - Omar AS
AD  - Department of Cardiothoracic Surgery/Cardiac Anesthesia and Intensive Care, Heart 
      Hospital, Hamad Medical Corporation, Doha, Qatar; Department of Critical Care 
      Medicine, Beni Suef University, Egypt; Weill Cornell Medical College, Doha, 
      Qatar.
FAU - Aljundi, Amer
AU  - Aljundi A
AD  - Department of Pharmacy, Heart Hospital, Hamad Medical Corporation, Doha, Qatar.
FAU - Kasem, Mohamed
AU  - Kasem M
AD  - Department of Pharmacy, Heart Hospital, Hamad Medical Corporation, Doha, Qatar.
FAU - Mahfouz, Ahmed
AU  - Mahfouz A
AD  - Department of Pharmacy, Heart Hospital, Hamad Medical Corporation, Doha, Qatar.
FAU - Alyafei, Sumaya
AU  - Alyafei S
AD  - Department of Pharmacy, Heart Hospital, Hamad Medical Corporation, Doha, Qatar.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20211126
PL  - Netherlands
TA  - Curr Probl Cardiol
JT  - Current problems in cardiology
JID - 7701802
RN  - 0 (Lactates)
RN  - 0 (Propanolamines)
RN  - MDY902UXSR (esmolol)
SB  - IM
MH  - *Extracorporeal Membrane Oxygenation
MH  - Humans
MH  - Lactates
MH  - *Myocardial Infarction
MH  - Propanolamines
MH  - Shock, Cardiogenic/etiology/therapy
EDAT- 2021/11/29 06:00
MHDA- 2022/09/28 06:00
CRDT- 2021/11/28 20:54
PHST- 2021/10/24 00:00 [received]
PHST- 2021/11/13 00:00 [revised]
PHST- 2021/11/21 00:00 [accepted]
PHST- 2021/11/29 06:00 [pubmed]
PHST- 2022/09/28 06:00 [medline]
PHST- 2021/11/28 20:54 [entrez]
AID - S0146-2806(21)00279-6 [pii]
AID - 10.1016/j.cpcardiol.2021.101071 [doi]
PST - ppublish
SO  - Curr Probl Cardiol. 2022 Nov;47(11):101071. doi: 10.1016/j.cpcardiol.2021.101071. 
      Epub 2021 Nov 26.