PMID- 34839012
OWN - NLM
STAT- MEDLINE
DCOM- 20220816
LR  - 20220827
IS  - 2210-3244 (Electronic)
IS  - 1672-0229 (Print)
IS  - 1672-0229 (Linking)
VI  - 19
IP  - 6
DP  - 2021 Dec
TI  - ASER: Animal Sex Reversal Database.
PG  - 873-881
LID - S1672-0229(21)00244-8 [pii]
LID - 10.1016/j.gpb.2021.10.001 [doi]
AB  - Sex reversal, representing extraordinary sexual plasticity during the life cycle, 
      not only triggers reproduction in animals but also affects reproductive and 
      endocrine system-related diseases and cancers in humans. Sex reversal has been 
      broadly reported in animals; however, an integrated resource hub of sex reversal 
      information is still lacking. Here, we constructed a comprehensive database named 
      ASER (Animal Sex Reversal) by integrating sex reversal-related data of 18 species 
      from teleostei to mammalia. We systematically collected 40,018 published papers 
      and mined the sex reversal-associated genes (SRGs), including their regulatory 
      networks, from 1611 core papers. We annotated homologous genes and computed 
      conservation scores for whole genomes across the 18 species. Furthermore, we 
      collected available RNA-seq datasets and investigated the expression dynamics of 
      SRGs during sex reversal or sex determination processes. In addition, we manually 
      annotated 550 in situ hybridization (ISH), fluorescence in situ hybridization 
      (FISH), and immunohistochemistry (IHC) images of SRGs from the literature and 
      described their spatial expression in the gonads. Collectively, ASER provides a 
      unique and integrated resource for researchers to query and reuse organized data 
      to explore the mechanisms and applications of SRGs in animal breeding and human 
      health. The ASER database is publicly available at http://aser.ihb.ac.cn/.
CI  - Copyright (c) 2021 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Li, Yangyang
AU  - Li Y
AD  - State Key Laboratory of Virology, College of Life Sciences, Wuhan University, 
      Wuhan 430072, China.
FAU - Chen, Zonggui
AU  - Chen Z
AD  - State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of 
      Hydrobiology, Innovation Academy for Seed Design, Chinese Academy of Sciences, 
      Wuhan 430072, China.
FAU - Liu, Hairong
AU  - Liu H
AD  - School of Basic Medical Science, Wuhan University, Wuhan 430071, China.
FAU - Li, Qiming
AU  - Li Q
AD  - State Key Laboratory of Virology, College of Life Sciences, Wuhan University, 
      Wuhan 430072, China.
FAU - Lin, Xing
AU  - Lin X
AD  - State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of 
      Hydrobiology, Innovation Academy for Seed Design, Chinese Academy of Sciences, 
      Wuhan 430072, China.
FAU - Ji, Shuhui
AU  - Ji S
AD  - School of Basic Medical Science, Wuhan University, Wuhan 430071, China.
FAU - Li, Rui
AU  - Li R
AD  - School of Basic Medical Science, Wuhan University, Wuhan 430071, China.
FAU - Li, Shaopeng
AU  - Li S
AD  - State Key Laboratory of Virology, College of Life Sciences, Wuhan University, 
      Wuhan 430072, China.
FAU - Fan, Weiliang
AU  - Fan W
AD  - State Key Laboratory of Virology, College of Life Sciences, Wuhan University, 
      Wuhan 430072, China.
FAU - Zhao, Haiping
AU  - Zhao H
AD  - School of Basic Medical Science, Wuhan University, Wuhan 430071, China.
FAU - Zhu, Zuoyan
AU  - Zhu Z
AD  - State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of 
      Hydrobiology, Innovation Academy for Seed Design, Chinese Academy of Sciences, 
      Wuhan 430072, China.
FAU - Hu, Wei
AU  - Hu W
AD  - State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of 
      Hydrobiology, Innovation Academy for Seed Design, Chinese Academy of Sciences, 
      Wuhan 430072, China; University of Chinese Academy of Sciences, Beijing 100049, 
      China. Electronic address: huwei@ihb.ac.cn.
FAU - Zhou, Yu
AU  - Zhou Y
AD  - State Key Laboratory of Virology, College of Life Sciences, Wuhan University, 
      Wuhan 430072, China; Frontier Science Center for Immunology and Metabolism, Wuhan 
      University, Wuhan 430072, China. Electronic address: yu.zhou@whu.edu.cn.
FAU - Luo, Daji
AU  - Luo D
AD  - State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of 
      Hydrobiology, Innovation Academy for Seed Design, Chinese Academy of Sciences, 
      Wuhan 430072, China; School of Basic Medical Science, Wuhan University, Wuhan 
      430071, China; University of Chinese Academy of Sciences, Beijing 100049, China. 
      Electronic address: luodaji@ihb.ac.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211125
PL  - England
TA  - Genomics Proteomics Bioinformatics
JT  - Genomics, proteomics & bioinformatics
JID - 101197608
SB  - IM
MH  - Animals
MH  - *Genome
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - *Reproduction/genetics
PMC - PMC9402789
OTO - NOTNLM
OT  - Conservation
OT  - Database
OT  - Omics
OT  - Sex reversal
OT  - Sex reversal-associated gene
EDAT- 2021/11/29 06:00
MHDA- 2022/08/17 06:00
PMCR- 2021/11/25
CRDT- 2021/11/28 20:56
PHST- 2021/01/06 00:00 [received]
PHST- 2021/10/25 00:00 [revised]
PHST- 2021/11/01 00:00 [accepted]
PHST- 2021/11/29 06:00 [pubmed]
PHST- 2022/08/17 06:00 [medline]
PHST- 2021/11/28 20:56 [entrez]
PHST- 2021/11/25 00:00 [pmc-release]
AID - S1672-0229(21)00244-8 [pii]
AID - 10.1016/j.gpb.2021.10.001 [doi]
PST - ppublish
SO  - Genomics Proteomics Bioinformatics. 2021 Dec;19(6):873-881. doi: 
      10.1016/j.gpb.2021.10.001. Epub 2021 Nov 25.