PMID- 34842475
OWN - NLM
STAT- MEDLINE
DCOM- 20220316
LR  - 20220316
IS  - 1465-3338 (Electronic)
IS  - 0307-9457 (Linking)
VI  - 51
IP  - 1
DP  - 2022 Feb
TI  - Comparative pathogenicity of Malaysian variant and very virulent infectious 
      bursal disease viruses in chickens.
PG  - 76-86
LID - 10.1080/03079457.2021.2006604 [doi]
AB  - Variant infectious bursal disease virus (vaIBDV) has been identified in various 
      countries with significant economic losses. Recently, the first identification of 
      a variant strain in Malaysia was reported. The pathogenicities of the Malaysian 
      variant, UPM1432/2019, and very virulent infectious bursal disease virus 
      (vvIBDV), UPM1056/2018 strains were comparatively evaluated in 
      specific-pathogen-free (SPF) chickens based on gross and histopathological 
      examinations and viral load. Four-week-old SPF chickens were randomly divided 
      into three groups; group 1 served as the control, while groups 2 and 3 birds were 
      challenged with the vaIBDV and vvIBDV, respectively. Three birds from each group 
      were weighed, euthanized and necropsied at 2, 3, 4, 5, 7 and 21 days 
      post-challenge (dpc). Unlike UPM1056/2018 group, birds from UPM1432/2019 group 
      did not show clinical signs or death. UPM1056/2018 strain caused 11% mortality 
      rate in the infected chickens. The bursal body index (BBIX) for UPM1432/2019- and 
      UPM1056/2018-infected groups was <0.7 from 2 dpc and continued to decrease to 
      0.49 and 0.45, respectively, at 21 dpc. UPM1432/2019 strain was more persistent 
      in the bursa than UPM1056/2018 strain. Both strains induced similar pathological 
      lesions in SPF chicks. These results indicate that the Malaysian vaIBDV severely 
      damaged the immune organs of chickens and was more persistent in bursal tissue 
      than vvIBDV. The study provides insight into the pathogenicity of the variant 
      strain as further study may be required to evaluate the efficacy of the currently 
      available IBD vaccines in Malaysia against the strain. RESEARCH 
      HIGHLIGHTSEmerging Malaysian variant IBDV caused severe bursal damage without 
      mortality.Atypical vvIBDV induced bursal atrophy with inflammatory response and 
      caused low mortality.Malaysian variant IBDV was more persistent in bursal tissue 
      than vvIBDV.
FAU - Aliyu, H B
AU  - Aliyu HB
AD  - Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, 
      Universiti Putra Malaysia Serdang, Malaysia.
AD  - Avian Unit, Veterinary Teaching Hospital, Ahmadu Bello University, Zaria, 
      Nigeria.
FAU - Hamisu, T M
AU  - Hamisu TM
AD  - Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, 
      Universiti Putra Malaysia Serdang, Malaysia.
AD  - Department of Veterinary Microbiology, Faculty of Veterinary Medicine, University 
      of Maiduguri, Maiduguri, Nigeria.
FAU - Hair Bejo, M
AU  - Hair Bejo M
AD  - Laboratory of Vaccines and Biomolecules, Institute of Bioscience, Universiti 
      Putra Malaysia Serdang, Malaysia.
AD  - Department of Veterinary Pathology and Microbiology, Faculty of Veterinary 
      Medicine, Universiti Putra Malaysia Serdang, Malaysia.
FAU - Omar, A R
AU  - Omar AR
AD  - Laboratory of Vaccines and Biomolecules, Institute of Bioscience, Universiti 
      Putra Malaysia Serdang, Malaysia.
AD  - Department of Veterinary Pathology and Microbiology, Faculty of Veterinary 
      Medicine, Universiti Putra Malaysia Serdang, Malaysia.
FAU - Ideris, A
AU  - Ideris A
AD  - Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, 
      Universiti Putra Malaysia Serdang, Malaysia.
AD  - Laboratory of Vaccines and Biomolecules, Institute of Bioscience, Universiti 
      Putra Malaysia Serdang, Malaysia.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial, Veterinary
PL  - England
TA  - Avian Pathol
JT  - Avian pathology : journal of the W.V.P.A
JID - 8210638
SB  - IM
MH  - Animals
MH  - *Birnaviridae Infections/veterinary
MH  - Chickens
MH  - *Infectious bursal disease virus/genetics
MH  - *Poultry Diseases
MH  - Virulence
OTO - NOTNLM
OT  - Infectious bursal disease virus
OT  - RT-qPCR
OT  - bursa
OT  - chicken
OT  - variant IBDV
OT  - vvIBDV
EDAT- 2021/11/30 06:00
MHDA- 2022/03/17 06:00
CRDT- 2021/11/29 12:20
PHST- 2021/11/30 06:00 [pubmed]
PHST- 2022/03/17 06:00 [medline]
PHST- 2021/11/29 12:20 [entrez]
AID - 10.1080/03079457.2021.2006604 [doi]
PST - ppublish
SO  - Avian Pathol. 2022 Feb;51(1):76-86. doi: 10.1080/03079457.2021.2006604.