PMID- 34842500
OWN - NLM
STAT- MEDLINE
DCOM- 20221108
LR  - 20221116
IS  - 1814-1412 (Electronic)
IS  - 1562-2975 (Linking)
VI  - 23
IP  - 5
DP  - 2022 Jun
TI  - Inefficient integration during multiple facial processing in pre-morbid and early 
      phases of psychosis.
PG  - 361-373
LID - 10.1080/15622975.2021.2011402 [doi]
AB  - OBJECTIVES: We used eye-tracking to evaluate multiple facial context processing 
      and event-related potential (ERP) to evaluate multiple facial recognition in 
      individuals at clinical high risk (CHR) for psychosis. METHODS: In total, 173 
      subjects (83 CHRs and 90 healthy controls [HCs]) were included and their emotion 
      perception performances were accessed. A total of 40 CHRs and 40 well-matched HCs 
      completed an eye-tracking task where they viewed pictures depicting a person in 
      the foreground, presented as context-free, context-compatible, and 
      context-incompatible. During the two-year follow-up, 26 CHRs developed psychosis, 
      including 17 individuals who developed first-episode schizophrenia (FES). 
      Eighteen well-matched HCs were made to complete the face number detection ERP 
      task with image stimuli of one, two, or three faces. RESULTS: Compared to the HC 
      group, the CHR group showed reduced visual attention to contextual processing 
      when viewing multiple faces. With the increasing complexity of contextual faces, 
      the differences in eye-tracking characteristics also increased. In the ERP task, 
      the N170 amplitude decreased with a higher face number in FES patients, while it 
      increased with a higher face number in HCs. CONCLUSIONS: Individuals in the very 
      early phase of psychosis showed facial processing deficits with supporting 
      evidence of different scan paths during context processing and disruption of N170 
      during multiple facial recognition.
FAU - Zhang, TianHong
AU  - Zhang T
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders(13dz2260500), Shanghai, China.
FAU - Yang, YingYu
AU  - Yang Y
AD  - School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
FAU - Xu, LiHua
AU  - Xu L
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders(13dz2260500), Shanghai, China.
FAU - Tang, XiaoChen
AU  - Tang X
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders(13dz2260500), Shanghai, China.
FAU - Hu, YeGang
AU  - Hu Y
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders(13dz2260500), Shanghai, China.
FAU - Xiong, Xin
AU  - Xiong X
AD  - School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
FAU - Wei, YanYan
AU  - Wei Y
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders(13dz2260500), Shanghai, China.
FAU - Cui, HuiRu
AU  - Cui H
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders(13dz2260500), Shanghai, China.
FAU - Tang, YingYing
AU  - Tang Y
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders(13dz2260500), Shanghai, China.
FAU - Liu, HaiChun
AU  - Liu H
AD  - Department of Automation, Shanghai Jiao Tong University, Shanghai, China.
FAU - Chen, Tao
AU  - Chen T
AD  - Big Data Research Lab, University of Waterloo, Waterloo, Ontario, Canada.
AD  - Senior Research Fellow, Labor and Worklife Program, Harvard University, 
      Cambridge, Massachusetts, United States.
AD  - Niacin (Shanghai) Technology Co., Ltd, Shanghai, China.
FAU - Liu, Zhi
AU  - Liu Z
AD  - School of Communication and Information Engineering, Shanghai University, 
      Shanghai, China.
FAU - Hui, Li
AU  - Hui L
AD  - Institute of Mental Health, The Affiliated Guangji Hospital of Soochow 
      University, Soochow University, Suzhou, Jiangsu, China.
FAU - Li, ChunBo
AU  - Li C
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders(13dz2260500), Shanghai, China.
FAU - Guo, XiaoLi
AU  - Guo X
AD  - School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
FAU - Wang, JiJun
AU  - Wang J
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders(13dz2260500), Shanghai, China.
AD  - Center for Excellence in Brain Science and Intelligence Technology (CEBSIT), 
      Chinese Academy of Science, Shanghai, China.
AD  - Institute of Psychology and Behavioral Science, Shanghai Jiao Tong University, 
      Shanghai, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211217
PL  - England
TA  - World J Biol Psychiatry
JT  - The world journal of biological psychiatry : the official journal of the World 
      Federation of Societies of Biological Psychiatry
JID - 101120023
SB  - IM
MH  - Humans
MH  - Facial Expression
MH  - Electroencephalography
MH  - *Facial Recognition
MH  - *Psychotic Disorders
MH  - Emotions
MH  - Evoked Potentials
OTO - NOTNLM
OT  - Psychosis
OT  - emotional processing biases
OT  - eye movement
OT  - schizophrenia
OT  - social cognition
EDAT- 2021/11/30 06:00
MHDA- 2022/11/09 06:00
CRDT- 2021/11/29 12:21
PHST- 2021/11/30 06:00 [pubmed]
PHST- 2022/11/09 06:00 [medline]
PHST- 2021/11/29 12:21 [entrez]
AID - 10.1080/15622975.2021.2011402 [doi]
PST - ppublish
SO  - World J Biol Psychiatry. 2022 Jun;23(5):361-373. doi: 
      10.1080/15622975.2021.2011402. Epub 2021 Dec 17.