PMID- 34842679
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211203
IS  - 2310-2861 (Electronic)
IS  - 2310-2861 (Linking)
VI  - 7
IP  - 4
DP  - 2021 Nov 5
TI  - Bone Regeneration Using MMP-Cleavable Peptides-Based Hydrogels.
LID - 10.3390/gels7040199 [doi]
LID - 199
AB  - Accumulating evidence has suggested the significant potential of chemically 
      modified hydrogels in bone regeneration. Despite the progress of bioactive 
      hydrogels with different materials, structures and loading cargoes, the desires 
      from clinical applications have not been fully validated. Multiple biological 
      behaviors are orchestrated precisely during the bone regeneration process, 
      including bone marrow mesenchymal stem cells (BMSCs) recruitment, osteogenic 
      differentiation, matrix calcification and well-organized remodeling. Since matrix 
      metalloproteinases play critical roles in such bone metabolism processes as BMSC 
      commitment, osteoblast survival, osteoclast activation matrix calcification and 
      microstructure remodeling, matrix metalloproteinase (MMP) cleavable 
      peptides-based hydrogels could respond to various MMP levels and, thus, 
      accelerate bone regeneration. In this review, we focused on the MMP-cleavable 
      peptides, polymers, functional modification and crosslinked reactions. 
      Applications, perspectives and limitations of MMP-cleavable peptides-based 
      hydrogels for bone regeneration were then discussed.
FAU - Chen, Weikai
AU  - Chen W
AD  - Institute of Translational Medicine, Shanghai University, Shanghai 200444, China.
AD  - School of Medicine, Shanghai University, Shanghai 200444, China.
AD  - School of Environmental and Chemical Engineering, Shanghai University, Shanghai 
      200444, China.
FAU - Zhou, Ziyang
AU  - Zhou Z
AD  - Institute of Translational Medicine, Shanghai University, Shanghai 200444, China.
AD  - School of Medicine, Shanghai University, Shanghai 200444, China.
AD  - School of Life Sciences, Shanghai University, Shanghai 200444, China.
FAU - Chen, Dagui
AU  - Chen D
AD  - Institute of Translational Medicine, Shanghai University, Shanghai 200444, China.
FAU - Li, Yinghua
AU  - Li Y
AD  - Institute of Translational Medicine, Shanghai University, Shanghai 200444, China.
FAU - Zhang, Qin
AU  - Zhang Q
AD  - Institute of Translational Medicine, Shanghai University, Shanghai 200444, China.
FAU - Su, Jiacan
AU  - Su J
AD  - Department of Trauma Orthopedics, Changhai Hospital, Naval Medical University, 
      Shanghai 200433, China.
AD  - Shanghai Clinical Research Center for Aging and Medicine, Shanghai 200040, China.
LA  - eng
GR  - 31800792/National Natural Science Foundation of China/
GR  - KX037FN/Beijing Bethune Charitable Foundation/
PT  - Journal Article
PT  - Review
DEP - 20211105
PL  - Switzerland
TA  - Gels
JT  - Gels (Basel, Switzerland)
JID - 101696925
PMC - PMC8628702
OTO - NOTNLM
OT  - MMP-cleavable peptides
OT  - bone regeneration
OT  - crosslinking
OT  - degradation
OT  - hydrogels
COIS- The authors declare no conflict of interest.
EDAT- 2021/11/30 06:00
MHDA- 2021/11/30 06:01
PMCR- 2021/11/05
CRDT- 2021/11/29 12:28
PHST- 2021/10/06 00:00 [received]
PHST- 2021/10/27 00:00 [revised]
PHST- 2021/11/03 00:00 [accepted]
PHST- 2021/11/29 12:28 [entrez]
PHST- 2021/11/30 06:00 [pubmed]
PHST- 2021/11/30 06:01 [medline]
PHST- 2021/11/05 00:00 [pmc-release]
AID - gels7040199 [pii]
AID - gels-07-00199 [pii]
AID - 10.3390/gels7040199 [doi]
PST - epublish
SO  - Gels. 2021 Nov 5;7(4):199. doi: 10.3390/gels7040199.