PMID- 34844628
OWN - NLM
STAT- MEDLINE
DCOM- 20211203
LR  - 20230921
IS  - 1751-0147 (Electronic)
IS  - 0044-605X (Print)
IS  - 0044-605X (Linking)
VI  - 63
IP  - 1
DP  - 2021 Nov 29
TI  - QimmeqHealth-thyroid status of Greenland sled dogs (Canis lupus familiaris 
      borealis).
PG  - 51
LID - 10.1186/s13028-021-00617-8 [doi]
LID - 51
AB  - BACKGROUND: Greenland sled dogs (GSD) are a unique, genetically isolated 
      population of dogs living under exceptional environmental conditions. Metabolism, 
      and thereby thyroid hormones are affected by multiple factors. Among other 
      activity, energy balance and environmental conditions are important. A 
      breed-specific reference interval (RI) can be useful for diagnostics of potential 
      thyroid-related pathologies. The aim of this study was to establish RIs of the 
      thyroid hormones thyroxin (T4), free thyroxin (fT4), and thyroid stimulating 
      hormone (TSH) in GSD. In addition to evaluate the effect of sex, age, season, 
      management, and body condition score (BCS) in GSD. Physical exams and cephalic 
      venous blood sampling were performed in the period of 2018-2019 from 265 GSD 
      managed either privately or by the Danish navy. Serum biochemical analyses, 
      including C-reactive protein, were performed and RIs were determined for TSH, T4 
      and fT4 in only healthy dogs. The RIs were determined using American Society for 
      Veterinary Clinical Pathology guidelines and the effect of varying factors were 
      evaluated by linear regression and further tested by Mann-Whitney test. RESULTS: 
      144 GSD were included in the reference group resulting in RIs: T4: 
      6.44-48.65 nmol/L; fT4: 3.91-18.51 pmol/L; and TSH: 0.04-0.55 ng/mL. Female GSD 
      had significantly higher concentrations of T4 (P = 0.039) and fT4 (P = 0.015) 
      compared to males; a positive correlation between TSH and aging was found; T4 
      concentrations were significantly higher (P = 0.003) during summer; and TSH 
      concentrations were lower in GSD managed by the navy (P < 0.0001). BCS was higher 
      (P < 0.0001) in Sirius GSD compared to civilian GSD, and BCS was positively 
      correlated with T4 and negatively correlated with TSH. CONCLUSIONS: Reference 
      intervals for T4, fT4 and TSH in GSD were established. The RI for T4 and fT4 was 
      lower compared to other breeds. In addition, sex, age, season, management and BCS 
      demonstrated variable effects on thyroid hormones. Our results can be used as a 
      foundation for improving management and further research of GSD.
CI  - (c) 2021. The Author(s).
FAU - Gjaldbaek, Bolette Winnerskjold
AU  - Gjaldbaek BW
AD  - Department of Veterinary Clinical Sciences, Faculty of Health and Medical 
      Sciences, University of Copenhagen, Dyrlaegevej 16, 1870, Frederiksberg C, 
      Denmark.
FAU - Andersen-Ranberg, Emilie Ulrikka
AU  - Andersen-Ranberg EU
AD  - Department of Veterinary Clinical Sciences, Faculty of Health and Medical 
      Sciences, University of Copenhagen, Dyrlaegevej 16, 1870, Frederiksberg C, 
      Denmark.
FAU - Langebaek, Rikke
AU  - Langebaek R
AD  - Department of Veterinary Clinical Sciences, Faculty of Health and Medical 
      Sciences, University of Copenhagen, Dyrlaegevej 16, 1870, Frederiksberg C, 
      Denmark.
FAU - Krogh, Anne Kirstine Havnsoe
AU  - Krogh AKH
AUID- ORCID: 0000-0003-0060-937X
AD  - Department of Veterinary Clinical Sciences, Faculty of Health and Medical 
      Sciences, University of Copenhagen, Dyrlaegevej 16, 1870, Frederiksberg C, 
      Denmark. akrk@sund.ku.dk.
LA  - eng
GR  - N2019-0014/Agria & Svenska Kennelklubben Forskningsfond/
GR  - 117728/Dansk Kennel Klub/
GR  - 113758/Beckett-Fonden (DK)/
PT  - Journal Article
DEP - 20211129
PL  - England
TA  - Acta Vet Scand
JT  - Acta veterinaria Scandinavica
JID - 0370400
RN  - 9002-71-5 (Thyrotropin)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Animals
MH  - *Dogs
MH  - Female
MH  - Greenland
MH  - Male
MH  - Reference Values
MH  - *Thyroid Gland
MH  - Thyrotropin/blood
MH  - Thyroxine/blood
PMC - PMC8630915
OTO - NOTNLM
OT  - Body condition score
OT  - Management
OT  - Reference interval
OT  - Season
OT  - Sled dogs
OT  - Thyroid hormones
COIS- The authors declare that they have no competing interests.
EDAT- 2021/12/01 06:00
MHDA- 2021/12/15 06:00
PMCR- 2021/11/29
CRDT- 2021/11/30 05:39
PHST- 2021/03/25 00:00 [received]
PHST- 2021/11/20 00:00 [accepted]
PHST- 2021/11/30 05:39 [entrez]
PHST- 2021/12/01 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/11/29 00:00 [pmc-release]
AID - 10.1186/s13028-021-00617-8 [pii]
AID - 617 [pii]
AID - 10.1186/s13028-021-00617-8 [doi]
PST - epublish
SO  - Acta Vet Scand. 2021 Nov 29;63(1):51. doi: 10.1186/s13028-021-00617-8.