PMID- 34847213
OWN - NLM
STAT- MEDLINE
DCOM- 20220131
LR  - 20220131
IS  - 2042-650X (Electronic)
IS  - 2042-6496 (Linking)
VI  - 12
IP  - 24
DP  - 2021 Dec 13
TI  - Curcumin supplementation improves biomarkers of oxidative stress and inflammation 
      in conditions of obesity, type 2 diabetes and NAFLD: updating the status of 
      clinical evidence.
PG  - 12235-12249
LID - 10.1039/d1fo02696h [doi]
AB  - Oxidative stress and inflammation remain the major complications implicated in 
      the development and progression of metabolic complications, including obesity, 
      type 2 diabetes (T2D) and nonalcoholic fatty liver disease (NAFLD). In fact, due 
      to their abundant antioxidant and anti-inflammatory properties, there is a 
      general interest in understanding the therapeutic effects of some major 
      food-derived bioactive compounds like curcumin against diverse metabolic 
      diseases. Hence, a systematic search, through prominent online databases such as 
      MEDLINE, Scopus, and Google Scholar was done focusing on randomized controlled 
      trials (RCTs) reporting on the impact of curcumin supplementation in individuals 
      with diverse metabolic complications, including obesity, T2D and NAFLD. 
      Summarized findings suggest that curcumin supplementation can significantly 
      reduce blood glucose and triglycerides levels, including markers of liver 
      function like alanine aminotransferase (ALT) and aspartate aminotransferase (AST) 
      in patients with T2D and NAFLD. Importantly, this effect was consistent with the 
      reduction of predominant markers of oxidative stress and inflammation, such as 
      the levels of malonaldehyde (MDA), tumor necrosis factor-alpha (TNF-alpha), high 
      sensitivity C-reactive protein (hs-CRP) and monocyte chemoattractant protein-1 
      (MCP-1) in these patients. Although RCTs suggest that curcumin is beneficial in 
      ameliorating some metabolic complications, future research is still necessary to 
      enhance its absorption and bioavailability profile, while also optimizing the 
      most effective therapeutic doses.
FAU - Mokgalaboni, Kabelo
AU  - Mokgalaboni K
AUID- ORCID: 0000-0002-3224-7433
AD  - School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, 
      Durban 4000, South Africa.
FAU - Ntamo, Yonela
AU  - Ntamo Y
AUID- ORCID: 0000-0002-7724-9547
AD  - Biomedical Research and Innovation Platform, South African Medical Research 
      Council, Tygerberg 7505, South Africa. pdludla@mrc.ac.za.
FAU - Ziqubu, Khanyisani
AU  - Ziqubu K
AD  - Department of Biochemistry, North-West University, Mmabatho 2745, South Africa.
FAU - Nyambuya, Tawanda M
AU  - Nyambuya TM
AD  - Department of Health Sciences, Namibia University of Science and Technology, 
      Windhoek 9000, Namibia.
FAU - Nkambule, Bongani B
AU  - Nkambule BB
AD  - School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, 
      Durban 4000, South Africa.
FAU - Mazibuko-Mbeje, Sithandiwe E
AU  - Mazibuko-Mbeje SE
AD  - Department of Biochemistry, North-West University, Mmabatho 2745, South Africa.
FAU - Gabuza, Kwazikwakhe B
AU  - Gabuza KB
AD  - School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, 
      Durban 4000, South Africa.
FAU - Chellan, Nireshni
AU  - Chellan N
AD  - Biomedical Research and Innovation Platform, South African Medical Research 
      Council, Tygerberg 7505, South Africa. pdludla@mrc.ac.za.
AD  - Division of Medical Physiology, Faculty of Health Sciences, Stellenbosch 
      University, Tygerberg 7505, South Africa.
FAU - Tiano, Luca
AU  - Tiano L
AD  - Department of Life and Environmental Sciences, Polytechnic University of Marche, 
      Ancona 60131, Italy.
FAU - Dludla, Phiwayinkosi V
AU  - Dludla PV
AUID- ORCID: 0000-0001-5965-3610
AD  - Biomedical Research and Innovation Platform, South African Medical Research 
      Council, Tygerberg 7505, South Africa. pdludla@mrc.ac.za.
LA  - eng
PT  - Journal Article
PT  - Systematic Review
DEP - 20211213
PL  - England
TA  - Food Funct
JT  - Food & function
JID - 101549033
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Antioxidants/*administration & dosage
MH  - Biomarkers/blood
MH  - Curcumin/*administration & dosage
MH  - Diabetes Mellitus, Type 2/blood/*diet therapy
MH  - *Dietary Supplements
MH  - Functional Food
MH  - Humans
MH  - Inflammation
MH  - Non-alcoholic Fatty Liver Disease/blood/*diet therapy
MH  - Obesity/blood/*diet therapy
MH  - Oxidative Stress/drug effects
EDAT- 2021/12/01 06:00
MHDA- 2022/02/01 06:00
CRDT- 2021/11/30 17:25
PHST- 2021/12/01 06:00 [pubmed]
PHST- 2022/02/01 06:00 [medline]
PHST- 2021/11/30 17:25 [entrez]
AID - 10.1039/d1fo02696h [doi]
PST - epublish
SO  - Food Funct. 2021 Dec 13;12(24):12235-12249. doi: 10.1039/d1fo02696h.