PMID- 34847405
OWN - NLM
STAT- MEDLINE
DCOM- 20220328
LR  - 20230102
IS  - 1872-7506 (Electronic)
IS  - 0925-4927 (Print)
IS  - 0925-4927 (Linking)
VI  - 319
DP  - 2022 Jan
TI  - Restoration of default mode network and task positive network anti-correlation 
      associated with mindfulness-based cognitive therapy for bipolar disorder.
PG  - 111419
LID - S0925-4927(21)00171-2 [pii]
LID - 10.1016/j.pscychresns.2021.111419 [doi]
AB  - Individuals with bipolar disorder (BP) show abnormalities in the default mode 
      network (DMN), a brain network active at rest and during self-referential 
      cognition. In healthy individuals, the DMN is anti-correlated (strongly 
      negatively correlated) with the task positive network (TPN), a brain network that 
      is active during attention demanding tasks. Mindfulness has been linked to 
      changes in DMN connectivity. We investigated the effects of mindfulness-based 
      cognitive therapy (MBCT) versus supportive psychotherapy (SP) on the relationship 
      between these two networks in individuals with BP. We identified differences in 
      BOLD resting state DMN-TPN connectivity between healthy controls (HC; n = 22) and 
      individuals with DSM-IV BP before treatment (n = 22) using a seed region in the 
      dorsolateral prefrontal cortex (DLPFC), a key TPN node. We then explored changes 
      in DMN-TPN connectivity after 12 weeks of MBCT or SP. Before treatment, BP 
      individuals showed positively correlated activity and the HC group showed 
      negatively correlated activity between the DLPFC and the posterior cingulate 
      cortex (PCC). After treatment, BP individuals who received MBCT showed negatively 
      correlated DLPFC-PCC activity. BP individuals who received SP did not show a 
      significant change. Mindfulness-based cognitive therapy can restore the 
      anti-correlation between the DMN and TPN in individuals with BP.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Chou, Tina
AU  - Chou T
AD  - Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, 
      Charlestown, MA, United States. Electronic address: tchou@mgh.harvard.edu.
FAU - Dougherty, Darin D
AU  - Dougherty DD
AD  - Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, 
      Charlestown, MA, United States.
FAU - Nierenberg, Andrew A
AU  - Nierenberg AA
AD  - Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, 
      Charlestown, MA, United States.
FAU - Deckersbach, Thilo
AU  - Deckersbach T
AD  - Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, 
      Charlestown, MA, United States; University of Applied Sciences, Diploma 
      Hochschule, Germany.
LA  - eng
GR  - K23 MH074895/MH/NIMH NIH HHS/United States
GR  - T32 NS100663/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20211125
PL  - Netherlands
TA  - Psychiatry Res Neuroimaging
JT  - Psychiatry research. Neuroimaging
JID - 101723001
SB  - IM
MH  - *Bipolar Disorder/diagnostic imaging/therapy
MH  - *Cognitive Behavioral Therapy
MH  - Default Mode Network
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - *Mindfulness
PMC - PMC8724460
MID - NIHMS1759979
OTO - NOTNLM
OT  - Attention
OT  - Dorsolateral prefrontal cortex
OT  - Mindfulness
OT  - Posterior cingulate cortex
EDAT- 2021/12/01 06:00
MHDA- 2022/03/29 06:00
PMCR- 2023/01/01
CRDT- 2021/11/30 20:10
PHST- 2021/07/27 00:00 [received]
PHST- 2021/11/18 00:00 [revised]
PHST- 2021/11/23 00:00 [accepted]
PHST- 2021/12/01 06:00 [pubmed]
PHST- 2022/03/29 06:00 [medline]
PHST- 2021/11/30 20:10 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - S0925-4927(21)00171-2 [pii]
AID - 10.1016/j.pscychresns.2021.111419 [doi]
PST - ppublish
SO  - Psychiatry Res Neuroimaging. 2022 Jan;319:111419. doi: 
      10.1016/j.pscychresns.2021.111419. Epub 2021 Nov 25.