PMID- 34847677
OWN - NLM
STAT- MEDLINE
DCOM- 20211203
LR  - 20211214
IS  - 1840-2879 (Electronic)
IS  - 1840-1848 (Linking)
VI  - 50
IP  - 2
DP  - 2021 Aug
TI  - Characteristics of Patients with Nonvariceal Upper Gastrointestinal Bleeding - 
      Are We Underestimating Gastroprotection during NSAIDs Therapy?
PG  - 244-251
LID - 10.5644/ama2006-124.340 [doi]
AB  - OBJECTIVE: The aim of our study was to determine the etiological factors, 
      treatment and outcome of patients with non-variceal bleeding from upper 
      gastrointestinal tract. MATERIALS AND METHODS: This study enrolled 200 patients 
      admitted to Sarajevo University Clinical Center with signs and symptoms of upper 
      gastrointestinal bleeding, from January 2019 to July 2020. All patients had 
      undergone gastroscopy, confirming the cause of gastrointestinal bleeding. 
      Clinical and laboratory data were collected retrospectively, including previous 
      non-steroid antiinflammatory drugs (NSAIDs) and anticoagulant therapy, 
      comorbidities, risk factors, as well as endoscopic findings, laboratory findings, 
      treatment and clinical follow-up. RESULTS: The majority of patients were men 
      (59%) with an average age of 53+/-6 years. Duodenal and gastric ulcers were the 
      most common cause, followed by other etiologies. In our study, previous NSAIDs 
      therapy had been registered in 29.5% of patients, anticoagulants in 8%, and 
      proton pump inhibitors (PPI) in 2.9% of patients. Endoscopic intervention was 
      required in 34% of patients. The need for transfusion occurred in 44.5% of cases. 
      Rebleeding during hospitalization was observed in 7.5% of patients, mortality in 
      1.5% and surgery in 3% of patients. CONCLUSION: The patients admitted to our 
      hospital with symptoms of acute nonvariceal upper gastrointestinal bleeding were 
      elderly, predominantly males, with significant comorbidities and a higher 
      incidence of NSAID use. Gastroprotection is underutilized during NSAID treatment 
      in patients with other coexisting risk factors, with a low rate of concomitant 
      use of PPI during NSAIDs therapy. Endoscopic therapy, together with PPI, 
      significantly reduces rebleeding rates, mortality and the number of emergency 
      surgical interventions.
CI  - Copyright (c) 2021 by Academy of Sciences and Arts of Bosnia and Herzegovina.
FAU - Custovic, Nerma
AU  - Custovic N
AD  - Clinic for gastroenterohepatology, Clinical University Center Sarajevo. 
      zahiragic.nerma@gmail.com.
FAU - Saray, Aida
AU  - Saray A
AD  - Clinic for gastroenterohepatology, Clinical University Center Sarajevo.
FAU - Cato-Mehmedbasic, Samra
AU  - Cato-Mehmedbasic S
AD  - Clinic for gastroenterohepatology, Clinical University Center Sarajevo.
FAU - Tancica, Ira
AU  - Tancica I
AD  - Clinic for gastroenterohepatology, Clinical University Center Sarajevo.
FAU - Spreckic, Sanjin
AU  - Spreckic S
AD  - Clinic for gastroenterohepatology, Clinical University Center Sarajevo.
FAU - Tokic, Nedim
AU  - Tokic N
AD  - Clinic for urgent medicine, Cinical University Center Sarajevo.
FAU - Herenda, Naida
AU  - Herenda N
AD  - Clinic for anesthesiology and reanimation, Clinical University Center Sarajevo.
LA  - eng
PT  - Journal Article
PL  - Bosnia and Herzegovina
TA  - Acta Med Acad
JT  - Acta medica academica
JID - 101587903
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
SB  - IM
MH  - Aged
MH  - *Anti-Inflammatory Agents, Non-Steroidal/therapeutic use
MH  - Female
MH  - *Gastrointestinal Hemorrhage/drug therapy
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Factors
OTO - NOTNLM
OT  - Forrest Classification
OT  - Mortality
OT  - Transfusion
EDAT- 2021/12/02 06:00
MHDA- 2021/12/15 06:00
CRDT- 2021/12/01 05:41
PHST- 2020/12/16 00:00 [received]
PHST- 2021/08/21 00:00 [accepted]
PHST- 2021/12/01 05:41 [entrez]
PHST- 2021/12/02 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
AID - ama2006-124.340 [pii]
AID - 10.5644/ama2006-124.340 [doi]
PST - ppublish
SO  - Acta Med Acad. 2021 Aug;50(2):244-251. doi: 10.5644/ama2006-124.340.