PMID- 34847843
OWN - NLM
STAT- MEDLINE
DCOM- 20220525
LR  - 20221027
IS  - 1875-6220 (Electronic)
IS  - 1570-1638 (Linking)
VI  - 19
IP  - 3
DP  - 2022
TI  - In-silico Screening of Phytoconstituents on Wound Healing Targets - Approaches 
      and Current Status.
PG  - e301121198426
LID - 10.2174/1570163819666211130141442 [doi]
AB  - Over recent years, there has been tremendous research focused on the effective 
      utilization of natural products in wound management. Natural or herbal products 
      contain several phytoconstituents that may act on various stages in wound healing 
      and thereby provide a multi-targeted approach especially in the treatment of 
      chronic wounds. Currently, attempts have been made to screen the 
      phytoconstituents present in herbs on various targets involved in wound healing. 
      This review includes a systematic evaluation of scientific reports by various 
      groups of researchers on the herbals evaluated for wound management, their 
      phytochemical profiling, pre-clinical studies, and molecular modeling studies. 
      Various wound targets discussed include Interleukin-1, Interleukin-6, Tumor 
      necrosis factor-alpha (TNF-alpha), Thymosin beta-4 (Tbeta-4) that regulate the early 
      inflammatory stage and the novel T cell immune response cDNA 7(TIRC7) that 
      regulates angiogenesis. Also, neuropeptides P and Y act on the inflammatory, 
      migratory, and proliferation phases, and growth factors like vascular endothelial 
      growth factor family (VEGF) and placental growth factor family (PGF) are involved 
      in angiogenesis, while the role of Fibroblast growth factor in tissue remodeling 
      is discussed. As many of the natural products include polyherbal systems, this 
      approach can help in the judicious selection of a combination of herbs that will 
      act on multiple targets in the wound healing process and provide a 
      multi-factorial approach in wound management.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Mandale, Vijaya
AU  - Mandale V
AD  - Department of Pharmaceutical Chemistry, Dr. D.Y. Patil Institute of 
      Pharmaceutical Sciences and Research, Pimpri, Pune, MS, India (Affiliated to the 
      Savitribai Phule Pune University, Pune, India).
FAU - Thomas, Asha
AU  - Thomas A
AD  - Department of Pharmaceutical Chemistry, Dr. D.Y. Patil Institute of 
      Pharmaceutical Sciences and Research, Pimpri, Pune, MS, India (Affiliated to the 
      Savitribai Phule Pune University, Pune, India).
FAU - Wavhale, Ravindra
AU  - Wavhale R
AD  - Department of Pharmaceutical Chemistry, Dr. D.Y. Patil Institute of 
      Pharmaceutical Sciences and Research, Pimpri, Pune, MS, India (Affiliated to the 
      Savitribai Phule Pune University, Pune, India).
FAU - Chitlange, Sohan
AU  - Chitlange S
AD  - Department of Pharmaceutical Chemistry, Dr. D.Y. Patil Institute of 
      Pharmaceutical Sciences and Research, Pimpri, Pune, MS, India (Affiliated to the 
      Savitribai Phule Pune University, Pune, India).
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Drug Discov Technol
JT  - Current drug discovery technologies
JID - 101157212
RN  - 0 (Biological Products)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 144589-93-5 (Placenta Growth Factor)
SB  - IM
MH  - *Biological Products/pharmacology/therapeutic use
MH  - Female
MH  - Humans
MH  - Placenta Growth Factor/pharmacology
MH  - *Vascular Endothelial Growth Factor A/metabolism/pharmacology
MH  - Wound Healing
OTO - NOTNLM
OT  - Growth factors
OT  - immunomodulators
OT  - molecular modeling
OT  - neuropeptides
OT  - phytoconstituents
OT  - wound healing
OT  - wound targets
EDAT- 2021/12/02 06:00
MHDA- 2022/05/26 06:00
CRDT- 2021/12/01 05:46
PHST- 2021/08/05 00:00 [received]
PHST- 2021/09/13 00:00 [revised]
PHST- 2021/09/14 00:00 [accepted]
PHST- 2021/12/02 06:00 [pubmed]
PHST- 2022/05/26 06:00 [medline]
PHST- 2021/12/01 05:46 [entrez]
AID - CDDT-EPUB-119141 [pii]
AID - 10.2174/1570163819666211130141442 [doi]
PST - ppublish
SO  - Curr Drug Discov Technol. 2022;19(3):e301121198426. doi: 
      10.2174/1570163819666211130141442.