PMID- 34849419
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220428
IS  - 2405-8440 (Print)
IS  - 2405-8440 (Electronic)
IS  - 2405-8440 (Linking)
VI  - 7
IP  - 11
DP  - 2021 Nov
TI  - Risk of type 2 diabetes mellitus and cardiovascular complications in KCNJ11, HHEX 
      and SLC30A8 genetic polymorphisms carriers: A case-control study.
PG  - e08376
LID - 10.1016/j.heliyon.2021.e08376 [doi]
LID - e08376
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) are 
      two deadly diseases caused by the complex interaction of multiple genetic loci, 
      lifestyle and environmental factors. Genome-wide association studies described 
      hundreds of susceptibility loci for T2DM and T2DM-related CVD, but it remains 
      uncertain due to geographic and ethnic variations. The objective of this study 
      was to evaluate the associations of KCNJ11 rs5219, SLC30A8 rs13266634 and HHEX 
      rs1111875 polymorphisms with T2DM and related CVD. METHODS: Genotyping of all 
      three polymorphisms was performed using polymerase chain reaction-restriction 
      fragment length polymorphism (PCR-RFLP) method on 250 T2DM cases and 246 healthy 
      controls. Both descriptive and inferential statistical methods were applied using 
      MedCalc and IBM SPSS software programs for statistical analyses. RESULTS: A 
      significantly increased association of KCNJ11 rs5219 (p<0.05) with T2DM was found 
      in dominant, recessive, heterozygote, homozygote, and allele model (aOR = 2.23, 
      2.03, 1.90, 3.09, and 1.80, respectively). For SLC30A8 rs13266634, only dominant, 
      heterozygote, and allele model (aOR = 3.37, 3.59, and 1.79, respectively) showed 
      significantly increased association with T2DM. SNP rs1111875 (HHEX) also revealed 
      2.08, 4.18, 5.93, and 2.08-times significant association in dominant, recessive, 
      homozygote, and allele models. Besides, a significantly reduced correlation of 
      KCNJ11 rs5219 was found with T2DM-related CVD in the recessive and allele model 
      (aOR = 0.40 and 0.65, respectively). Again, a significant difference was observed 
      between T2DM-related CVD and non-CVD patients in terms of gender distribution, 
      fasting blood glucose (FBG), systolic blood pressure (SBP), diastolic blood 
      pressure (DBP), total cholesterol (TC), and triglycerides (TG). CONCLUSIONS: Our 
      investigation indicates that KCNJ11 rs5219, SLC30A8 rs13266634 and HHEX rs1111875 
      polymorphisms are associated with T2DM. Moreover, KCNJ11 rs5219 polymorphism is 
      correlated with the risk of T2DM-related CVD.
CI  - (c) 2021 The Author(s).
FAU - Aka, Tutun Das
AU  - Aka TD
AD  - Department of Pharmacy, Faculty of Science, Noakhali Science and Technology 
      University, Sonapur, 3814, Noakhali, Bangladesh.
FAU - Saha, Urmi
AU  - Saha U
AD  - Department of Pharmacy, Faculty of Science, Noakhali Science and Technology 
      University, Sonapur, 3814, Noakhali, Bangladesh.
FAU - Shati, Sayara Akter
AU  - Shati SA
AD  - Department of Pharmacy, Faculty of Science, Noakhali Science and Technology 
      University, Sonapur, 3814, Noakhali, Bangladesh.
FAU - Aziz, Md Abdul
AU  - Aziz MA
AD  - Department of Pharmacy, Faculty of Science, Noakhali Science and Technology 
      University, Sonapur, 3814, Noakhali, Bangladesh.
AD  - Laboratory of Pharmacogenomics and Molecular Biology, Department of Pharmacy, 
      Noakhali Science and Technology University, Sonapur, 3814, Noakhali, Bangladesh.
FAU - Begum, Mobashera
AU  - Begum M
AD  - Department of Pharmacy, Faculty of Science, Noakhali Science and Technology 
      University, Sonapur, 3814, Noakhali, Bangladesh.
FAU - Hussain, Md Saddam
AU  - Hussain MS
AD  - Department of Pharmacy, Faculty of Science, Noakhali Science and Technology 
      University, Sonapur, 3814, Noakhali, Bangladesh.
FAU - Millat, Md Shalahuddin
AU  - Millat MS
AD  - Department of Pharmacy, Faculty of Science, Noakhali Science and Technology 
      University, Sonapur, 3814, Noakhali, Bangladesh.
AD  - Laboratory of Pharmacogenomics and Molecular Biology, Department of Pharmacy, 
      Noakhali Science and Technology University, Sonapur, 3814, Noakhali, Bangladesh.
FAU - Uddin, Mohammad Sarowar
AU  - Uddin MS
AD  - Department of Pharmacy, Faculty of Science, Noakhali Science and Technology 
      University, Sonapur, 3814, Noakhali, Bangladesh.
AD  - Laboratory of Pharmacogenomics and Molecular Biology, Department of Pharmacy, 
      Noakhali Science and Technology University, Sonapur, 3814, Noakhali, Bangladesh.
FAU - Islam, Mohammad Safiqul
AU  - Islam MS
AD  - Department of Pharmacy, Faculty of Science, Noakhali Science and Technology 
      University, Sonapur, 3814, Noakhali, Bangladesh.
AD  - Laboratory of Pharmacogenomics and Molecular Biology, Department of Pharmacy, 
      Noakhali Science and Technology University, Sonapur, 3814, Noakhali, Bangladesh.
LA  - eng
PT  - Journal Article
DEP - 20211117
PL  - England
TA  - Heliyon
JT  - Heliyon
JID - 101672560
PMC - PMC8608605
OTO - NOTNLM
OT  - Cardiovascular disease
OT  - HHEX
OT  - KCNJ11
OT  - Polymorphism
OT  - SLC30A8
OT  - Type 2 diabetes mellitus
COIS- The authors declare no conflict of interest.
EDAT- 2021/12/02 06:00
MHDA- 2021/12/02 06:01
PMCR- 2021/11/17
CRDT- 2021/12/01 06:58
PHST- 2021/07/12 00:00 [received]
PHST- 2021/10/15 00:00 [revised]
PHST- 2021/11/10 00:00 [accepted]
PHST- 2021/12/01 06:58 [entrez]
PHST- 2021/12/02 06:00 [pubmed]
PHST- 2021/12/02 06:01 [medline]
PHST- 2021/11/17 00:00 [pmc-release]
AID - S2405-8440(21)02479-8 [pii]
AID - e08376 [pii]
AID - 10.1016/j.heliyon.2021.e08376 [doi]
PST - epublish
SO  - Heliyon. 2021 Nov 17;7(11):e08376. doi: 10.1016/j.heliyon.2021.e08376. 
      eCollection 2021 Nov.