PMID- 34850268
OWN - NLM
STAT- MEDLINE
DCOM- 20211224
LR  - 20230517
IS  - 1432-1963 (Electronic)
IS  - 0172-8113 (Print)
IS  - 0172-8113 (Linking)
VI  - 42
IP  - Suppl 2
DP  - 2021 Dec
TI  - [Clinical, radiological, and histopathological features of pulmonary post-COVID 
      syndrome : A form of autoimmune-mediated interstitial lung disease?].
PG  - 160-164
LID - 10.1007/s00292-021-01024-6 [doi]
AB  - BACKGROUND: About 10% of patients develop persistent symptoms after mild/moderate 
      COVID-19. We have previously reported detection of antinuclear 
      autoantibodies/extractable nuclear antigens (ANA/ENA) in patients with severe 
      COVID-19. OBJECTIVES: The aim of this small pilot study was to characterize 
      long-/post-COVID and to evaluate possible similarities between lung involvement 
      in long-/post-COVID and connective tissue disease (CTD). METHODS: We 
      prospectively enrolled 33 previously healthy patients with persistent pulmonal 
      symptoms after mild/moderate COVID-19 without hospitalization (median age, 
      39 years). We performed clinical evaluation including pulmonary function tests, 
      computed tomography (CT), and serology for ANA/ENA. In 29 of 33 patients, 
      transbronchial biopsies (TBBs) were taken for histopathological assessment. 
      RESULTS: Most patients presented with disturbed oxygen pulse in spiroergometry 
      and slight lymphocytosis in bronchoalveolar lavage (BAL) fluid. The CT pattern 
      showed bronchial wall thickening and increased low-attenuation volume. 
      Autoantibodies were detected in 13 of 33 patients (39.4%). Histopathological 
      assessment showed interstitial lymphocytosis with alveolar fibrin and organizing 
      pneumonia. Ultrastructural analyses revealed interstitial collagen deposition. 
      CONCLUSION: While histopathology of pulmonary long-/post-COVID alone is 
      unspecific, the combination with clinical and radiological features together with 
      detection of autoantibodies would allow for a diagnosis of interstitial pneumonia 
      with autoimmune features (IPAF). Since we observe interstitial collagen 
      deposition and since IPAF/CTD-ILD might progress to fibrosis, the persistence of 
      autoantibodies and possible fibrotic change should be closely monitored in 
      autoantibody-positive long-/post-COVID patients.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, 
      ein Teil von Springer Nature.
FAU - Steinestel, K
AU  - Steinestel K
AD  - Abt. XIII, Institut fur Pathologie und Molekularpathologie, Bundeswehrkrankenhaus 
      Ulm, Oberer Eselsberg 40, 89081, Ulm, Deutschland. 
      konradsteinestel@bundeswehr.org.
FAU - Czech, A
AU  - Czech A
AD  - Abt. XIII, Institut fur Pathologie und Molekularpathologie, Bundeswehrkrankenhaus 
      Ulm, Oberer Eselsberg 40, 89081, Ulm, Deutschland.
FAU - Hackenbroch, C
AU  - Hackenbroch C
AD  - Abteilung Radiologie, Bundeswehrkrankenhaus Ulm, Ulm, Deutschland.
FAU - Bloch, W
AU  - Bloch W
AD  - Molekulare und zellulare Sportmedizin, Deutsche Sporthochschule Koln, Koln, 
      Deutschland.
FAU - Gagiannis, D
AU  - Gagiannis D
AD  - Klinik fur Innere Medizin - Pneumologie, Bundeswehrkrankenhaus Ulm, Ulm, 
      Deutschland.
LA  - ger
PT  - Journal Article
PT  - Review
TT  - Klinische, radiologische und histopathologische Merkmale des pulmonalen 
      Post-COVID-Syndroms : Eine Form der autoimmunvermittelten interstitiellen 
      Lungenerkrankung?
DEP - 20211130
PL  - Germany
TA  - Pathologe
JT  - Der Pathologe
JID - 8006541
SB  - IM
MH  - Adult
MH  - *COVID-19
MH  - Humans
MH  - Lung/diagnostic imaging
MH  - *Lung Diseases, Interstitial
MH  - Pilot Projects
MH  - SARS-CoV-2
PMC - PMC8631553
OTO - NOTNLM
OT  - COVID-19
OT  - Fibrosis
OT  - ILD
OT  - Long-COVID
OT  - SARS-CoV‑2
EDAT- 2021/12/02 06:00
MHDA- 2021/12/25 06:00
PMCR- 2021/11/30
CRDT- 2021/12/01 07:31
PHST- 2021/10/29 00:00 [accepted]
PHST- 2021/12/02 06:00 [pubmed]
PHST- 2021/12/25 06:00 [medline]
PHST- 2021/12/01 07:31 [entrez]
PHST- 2021/11/30 00:00 [pmc-release]
AID - 10.1007/s00292-021-01024-6 [pii]
AID - 1024 [pii]
AID - 10.1007/s00292-021-01024-6 [doi]
PST - ppublish
SO  - Pathologe. 2021 Dec;42(Suppl 2):160-164. doi: 10.1007/s00292-021-01024-6. Epub 
      2021 Nov 30.