PMID- 34850281
OWN - NLM
STAT- MEDLINE
DCOM- 20211203
LR  - 20211214
IS  - 0070-217X (Print)
IS  - 0070-217X (Linking)
VI  - 434
DP  - 2021
TI  - Cellular Niches for Hematopoietic Stem Cells and Lympho-Hematopoiesis in Bone 
      Marrow During Homeostasis and Blood Cancers.
PG  - 33-54
LID - 10.1007/978-3-030-86016-5_2 [doi]
AB  - Most types of blood cells, including immune cells are generated from 
      hematopoietic stem cells (HSCs) within bone marrow in the adult. Most HSCs are in 
      contact with and require the special microenvironment known as a niche for their 
      maintenance. It has been thought that HSC niches comprise various types of 
      support cells that provide critical signals, including cytokines and 
      extracellular matrix for HSC regulation. However, among these cells, several 
      lines of evidence have demonstrated that the population of bone marrow-specific 
      mesenchymal stem cells, termed CXC chemokine ligand 12 (CXCL12)-abundant 
      reticular (CAR) cells, which overlap strongly with leptin receptor-expressing 
      (LepR(+)) cells, is the major cellular component of HSC niches. CAR/LepR(+) cells 
      give rise to most adipocytes and osteoblasts in adult bone marrow and express 
      much higher levels of HSC niche factors, including cytokines CXCL12 and stem cell 
      factor (SCF), which are essential for HSC maintenance, and transcription factors 
      Foxc1 and Ebf3, which are essential for the formation and maintenance of HSC 
      niches than other types of cells. CAR/LepR(+) cells are present in human bone 
      marrow, undergo fibrotic expansion, and have reduced expression of HSC niche 
      factors in hematopoietic malignancies.
CI  - (c) 2021. The Author(s), under exclusive license to Springer Nature Switzerland AG.
FAU - Omatsu, Yoshiki
AU  - Omatsu Y
AD  - Laboratory of Stem Cell Biology and Developmental Immunology, Graduate School of 
      Frontier Biosciences and Graduate School of Medicine, WPI Immunology Frontier 
      Research Center, Osaka University, Suita, 565-0871, Osaka, Japan.
FAU - Higaki, Kei
AU  - Higaki K
AD  - Laboratory of Stem Cell Biology and Developmental Immunology, Graduate School of 
      Frontier Biosciences and Graduate School of Medicine, WPI Immunology Frontier 
      Research Center, Osaka University, Suita, 565-0871, Osaka, Japan.
FAU - Nagasawa, Takashi
AU  - Nagasawa T
AD  - Laboratory of Stem Cell Biology and Developmental Immunology, Graduate School of 
      Frontier Biosciences and Graduate School of Medicine, WPI Immunology Frontier 
      Research Center, Osaka University, Suita, 565-0871, Osaka, Japan. 
      tnagasa@fbs.osaka-u.ac.jp.
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Curr Top Microbiol Immunol
JT  - Current topics in microbiology and immunology
JID - 0110513
SB  - IM
MH  - Bone Marrow
MH  - *Hematologic Neoplasms/genetics
MH  - Hematopoiesis
MH  - Hematopoietic Stem Cells
MH  - Homeostasis
MH  - Humans
MH  - *Neoplasms
MH  - Stem Cell Niche
MH  - Tumor Microenvironment
EDAT- 2021/12/02 06:00
MHDA- 2021/12/15 06:00
CRDT- 2021/12/01 07:32
PHST- 2021/12/01 07:32 [entrez]
PHST- 2021/12/02 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
AID - 10.1007/978-3-030-86016-5_2 [doi]
PST - ppublish
SO  - Curr Top Microbiol Immunol. 2021;434:33-54. doi: 10.1007/978-3-030-86016-5_2.