PMID- 34850366
OWN - NLM
STAT- MEDLINE
DCOM- 20220602
LR  - 20220705
IS  - 1880-344X (Electronic)
IS  - 1349-0222 (Linking)
VI  - 20
IP  - 2
DP  - 2022 Jun
TI  - Echocardiographic assessment of right ventricular volume in repaired tetralogy of 
      Fallot: a novel approach to an older technique.
PG  - 106-114
LID - 10.1007/s12574-021-00558-1 [doi]
AB  - BACKGROUND: In repaired tetralogy of Fallot (rTOF), right ventricular (RV) 
      enlargement leads to poor outcomes. However, evaluating the RV has limitations; 
      cardiac magnetic resonance (CMR) and 3D echocardiography have barriers including 
      cost and accessibility. Traditional echocardiography is limited given the complex 
      geometry and anterior location of the RV. We propose a novel echocardiographic 
      evaluation of RV volume using 2 separate views. METHODS: This is a retrospective 
      study of rTOF patients with echocardiogram, CMR, and exercise tests. By 
      echocardiogram, we collected RV length in parasternal long axis (PLAX), area in 
      4-chamber (4C) view, and measurements per standard guidelines. RV end-diastolic 
      and end-systolic volume (RVEDV and RVESV) were calculated as 5/9 (4C area * PLAX 
      length). RESULTS: Forty-five patients with 66 sets of CMR, echocardiogram, and 
      exercise tests were included (mean age 13.3 +/- 3.2 years). The echocardiographic 
      RVEDV and RVESV showed strong correlation with CMR parameters (r = 0.81 and 0.72; 
      p</= 0.0001), and moderate correlation with peak oxygen pulse (0.63 and 0.49; 
      p</=0.0001). Guideline measurements had no significant correlation. 
      Echocardiographic RVEDV and RVESV were higher in those requiring subsequent 
      pulmonary valve replacement. Indexed echocardiographic RVEDV of 93 ml/m(2) had 
      92% sensitivity and 50% specificity (area under curve 0.75 (p = 0.001)) in 
      predicting CMR RV/LV EDV ratio > 2, which is an early indicator for pulmonary 
      valve replacement. CONCLUSIONS: This novel technique correlates strongly with 
      CMR, better than traditional parameters. While echocardiogram will not replace 
      CMR, this method would be useful in predicting the RV volume, progression of 
      dilation, and timing of CMR.
CI  - (c) 2021. Japanese Society of Echocardiography.
FAU - Lee, Joan K
AU  - Lee JK
AUID- ORCID: 0000-0002-9749-9551
AD  - Department of Pediatric Cardiology, Seattle Children's Hospital, University of 
      Washington, 400 Sand Point Way NE, Seattle, WA, 98105, USA. joanleemd@gmail.com.
FAU - Chikkabyrappa, Sathish Mallenahalli
AU  - Chikkabyrappa SM
AD  - Department of Pediatric Cardiology, Seattle Children's Hospital, University of 
      Washington, 400 Sand Point Way NE, Seattle, WA, 98105, USA.
FAU - Bhat, Aarti
AU  - Bhat A
AD  - Department of Pediatric Cardiology, Seattle Children's Hospital, University of 
      Washington, 400 Sand Point Way NE, Seattle, WA, 98105, USA.
FAU - Buddhe, Sujatha
AU  - Buddhe S
AD  - Department of Pediatric Cardiology, Seattle Children's Hospital, University of 
      Washington, 400 Sand Point Way NE, Seattle, WA, 98105, USA.
LA  - eng
PT  - Journal Article
DEP - 20211130
PL  - Japan
TA  - J Echocardiogr
JT  - Journal of echocardiography
JID - 101263153
SB  - IM
MH  - Adolescent
MH  - *Cardiac Surgical Procedures/methods
MH  - Child
MH  - Echocardiography/methods
MH  - Heart Ventricles/diagnostic imaging
MH  - Humans
MH  - Retrospective Studies
MH  - Stroke Volume
MH  - *Tetralogy of Fallot/surgery
MH  - *Ventricular Dysfunction, Right/diagnostic imaging/etiology
MH  - Ventricular Function, Right
OTO - NOTNLM
OT  - Cardiac MRI
OT  - Echocardiography
OT  - Exercise test
OT  - Right ventricular volume
OT  - Tetralogy of Fallot
EDAT- 2021/12/02 06:00
MHDA- 2022/06/03 06:00
CRDT- 2021/12/01 07:36
PHST- 2020/12/16 00:00 [received]
PHST- 2021/11/10 00:00 [accepted]
PHST- 2021/09/30 00:00 [revised]
PHST- 2021/12/02 06:00 [pubmed]
PHST- 2022/06/03 06:00 [medline]
PHST- 2021/12/01 07:36 [entrez]
AID - 10.1007/s12574-021-00558-1 [pii]
AID - 10.1007/s12574-021-00558-1 [doi]
PST - ppublish
SO  - J Echocardiogr. 2022 Jun;20(2):106-114. doi: 10.1007/s12574-021-00558-1. Epub 
      2021 Nov 30.